Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody‐dependent (AD) NK cell activation and ADCC

• Published in: Journal of leukocyte biology Vol. 105; no. 3; pp. 551 - 563
• Main Authors: Lisovsky, Irene, Kant, Sanket, Tremblay‐McLean, Alexandra, Isitman, Gamze, Kiani, Zahra, Dupuy, Franck P., Gilbert, Louise, Bruneau, Julie, Shoukry, Naglaa H., Lebouché, Bertrand, Bernard, Nicole F.
• Format: Journal Article
• Language: English
• Published: United States John Wiley and Sons Inc 01.03.2019
• Subjects: Ab‐dependent NK cell activation; ADCC; Antibodies - pharmacology; Antibody-Dependent Cell Cytotoxicity - immunology; Fluorescence; Granzymes - metabolism; Host Defense & Pathophysiology; Humans; Killer Cells, Natural - immunology; KIR; Lymphocyte Activation - immunology; NK cell education; NKG2A; Perforin - metabolism; Receptors, KIR2DL1 - metabolism; Receptors, KIR2DL3 - metabolism; Receptors, KIR3DL1 - metabolism; Ab-dependent NK cell activation; KIR; NK cell education; ADCC; NKG2A

The engagement of activating NK receptors (aNKR) stimulates NK cell activity, provided that interactions between inhibitory NK receptors (iNKR) with their HLA ligands do not override them. Abs bound to target cells can also activate NK cells by engaging the CD16 aNKR. NK cell education status is an...