Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody‐dependent (AD) NK cell activation and ADCC

The engagement of activating NK receptors (aNKR) stimulates NK cell activity, provided that interactions between inhibitory NK receptors (iNKR) with their HLA ligands do not override them. Abs bound to target cells can also activate NK cells by engaging the CD16 aNKR. NK cell education status is an...

Full description

Saved in:
Bibliographic Details
Published inJournal of leukocyte biology Vol. 105; no. 3; pp. 551 - 563
Main Authors Lisovsky, Irene, Kant, Sanket, Tremblay‐McLean, Alexandra, Isitman, Gamze, Kiani, Zahra, Dupuy, Franck P., Gilbert, Louise, Bruneau, Julie, Shoukry, Naglaa H., Lebouché, Bertrand, Bernard, Nicole F.
Format Journal Article
LanguageEnglish
Published United States John Wiley and Sons Inc 01.03.2019
Subjects
Ab‐dependent NK cell activation
ADCC
Antibodies - pharmacology
Antibody-Dependent Cell Cytotoxicity - immunology
Fluorescence
Granzymes - metabolism
Host Defense & Pathophysiology
Humans
Killer Cells, Natural - immunology
KIR
Lymphocyte Activation - immunology
NK cell education
NKG2A
Perforin - metabolism
Receptors, KIR2DL1 - metabolism
Receptors, KIR2DL3 - metabolism
Receptors, KIR3DL1 - metabolism
Ab-dependent NK cell activation
KIR
NK cell education
ADCC
NKG2A
Online AccessGet full text

Cover

Abstract The engagement of activating NK receptors (aNKR) stimulates NK cell activity, provided that interactions between inhibitory NK receptors (iNKR) with their HLA ligands do not override them. Abs bound to target cells can also activate NK cells by engaging the CD16 aNKR. NK cell education status is an important factor for Ab‐dependent NK cell activation (ADNKA) of some NK cell subsets. However, whether NK cell education also influences Ab‐dependent cellular cytotoxicity (ADCC) levels is not fully known. ADCC‐GranToxiLux (GTL) assays measured ADCC activity as the frequency of granzyme B positive (%GzB+) target cells. Target cells were anti‐HIV Immunoglobulin G (HIVIG)‐opsonized CEM‐NKr.CCR5 (CEM) cells. Lymphocytes and sorted single positive (SP) NKG2A+, KIR2DL1+, KIR2DL3+, and KIR3DL1+ NK cells, to self‐ and nonself HLA, were used as effectors in ADCC‐GTL assays to examine how education status influenced ADCC activity. ADNKA activity was assessed by stimulating lymphocytes with HIVIG‐opsonized CEMs and measuring the frequency of NK cell populations defined by their expression of iNKRs, along with IFN‐γ, CCL4, and CD107a functions. ADCC: the %GzB+ CEM cells generated by self‐ versus nonself HLA‐specific SPiNKR did not differ. ADNKA: More NK cells educated through KIR2DL1 and KIR3DL1, but not KIR2DL3, responded to ADNKA than their uneducated counterparts. CD16 engagement induced ADCC and ADNKA activity. With the proviso that groups’ sizes were small, our results support the notion that NK cell education does not influence ADCC levels but does contribute to ADNKA activity. NK cell education through inhibitory Killer Immunoglobulin‐like Receptors activates antibody‐dependent NK cell functions but mediate antibody‐dependent cellular cytotocitiy no better than their uneducated counterparts.
AbstractList The engagement of activating NK receptors (aNKR) stimulates NK cell activity, provided that interactions between inhibitory NK receptors (iNKR) with their HLA ligands do not override them. Abs bound to target cells can also activate NK cells by engaging the CD16 aNKR. NK cell education status is an important factor for Ab‐dependent NK cell activation (ADNKA) of some NK cell subsets. However, whether NK cell education also influences Ab‐dependent cellular cytotoxicity (ADCC) levels is not fully known. ADCC‐GranToxiLux (GTL) assays measured ADCC activity as the frequency of granzyme B positive (%GzB+) target cells. Target cells were anti‐HIV Immunoglobulin G (HIVIG)‐opsonized CEM‐NKr.CCR5 (CEM) cells. Lymphocytes and sorted single positive (SP) NKG2A+, KIR2DL1+, KIR2DL3+, and KIR3DL1+ NK cells, to self‐ and nonself HLA, were used as effectors in ADCC‐GTL assays to examine how education status influenced ADCC activity. ADNKA activity was assessed by stimulating lymphocytes with HIVIG‐opsonized CEMs and measuring the frequency of NK cell populations defined by their expression of iNKRs, along with IFN‐γ, CCL4, and CD107a functions. ADCC: the %GzB+ CEM cells generated by self‐ versus nonself HLA‐specific SPiNKR did not differ. ADNKA: More NK cells educated through KIR2DL1 and KIR3DL1, but not KIR2DL3, responded to ADNKA than their uneducated counterparts. CD16 engagement induced ADCC and ADNKA activity. With the proviso that groups’ sizes were small, our results support the notion that NK cell education does not influence ADCC levels but does contribute to ADNKA activity. NK cell education through inhibitory Killer Immunoglobulin‐like Receptors activates antibody‐dependent NK cell functions but mediate antibody‐dependent cellular cytotocitiy no better than their uneducated counterparts.
The engagement of activating NK receptors (aNKR) stimulates NK cell activity, provided that interactions between inhibitory NK receptors (iNKR) with their HLA ligands do not override them. Abs bound to target cells can also activate NK cells by engaging the CD16 aNKR. NK cell education status is an important factor for Ab-dependent NK cell activation (ADNKA) of some NK cell subsets. However, whether NK cell education also influences Ab-dependent cellular cytotoxicity (ADCC) levels is not fully known. ADCC-GranToxiLux (GTL) assays measured ADCC activity as the frequency of granzyme B positive (%GzB+) target cells. Target cells were anti-HIV Immunoglobulin G (HIVIG)-opsonized CEM-NKr.CCR5 (CEM) cells. Lymphocytes and sorted single positive (SP) NKG2A+, KIR2DL1+, KIR2DL3+, and KIR3DL1+ NK cells, to self- and nonself HLA, were used as effectors in ADCC-GTL assays to examine how education status influenced ADCC activity. ADNKA activity was assessed by stimulating lymphocytes with HIVIG-opsonized CEMs and measuring the frequency of NK cell populations defined by their expression of iNKRs, along with IFN-γ, CCL4, and CD107a functions. ADCC: the %GzB+ CEM cells generated by self- versus nonself HLA-specific SPiNKR did not differ. ADNKA: More NK cells educated through KIR2DL1 and KIR3DL1, but not KIR2DL3, responded to ADNKA than their uneducated counterparts. CD16 engagement induced ADCC and ADNKA activity. With the proviso that groups’ sizes were small, our results support the notion that NK cell education does not influence ADCC levels but does contribute to ADNKA activity.
The engagement of activating NK receptors (aNKR) stimulates NK cell activity, provided that interactions between inhibitory NK receptors (iNKR) with their HLA ligands do not override them. Abs bound to target cells can also activate NK cells by engaging the CD16 aNKR. NK cell education status is an important factor for Ab‐dependent NK cell activation (ADNKA) of some NK cell subsets. However, whether NK cell education also influences Ab‐dependent cellular cytotoxicity (ADCC) levels is not fully known. ADCC‐GranToxiLux (GTL) assays measured ADCC activity as the frequency of granzyme B positive (%GzB + ) target cells. Target cells were anti‐HIV Immunoglobulin G (HIVIG)‐opsonized CEM‐NKr.CCR5 (CEM) cells. Lymphocytes and sorted single positive (SP) NKG2A + , KIR2DL1 + , KIR2DL3 + , and KIR3DL1 + NK cells, to self‐ and nonself HLA, were used as effectors in ADCC‐GTL assays to examine how education status influenced ADCC activity. ADNKA activity was assessed by stimulating lymphocytes with HIVIG‐opsonized CEMs and measuring the frequency of NK cell populations defined by their expression of iNKRs, along with IFN‐γ, CCL4, and CD107a functions. ADCC: the %GzB + CEM cells generated by self‐ versus nonself HLA‐specific SPiNKR did not differ. ADNKA: More NK cells educated through KIR2DL1 and KIR3DL1, but not KIR2DL3, responded to ADNKA than their uneducated counterparts. CD16 engagement induced ADCC and ADNKA activity. With the proviso that groups’ sizes were small, our results support the notion that NK cell education does not influence ADCC levels but does contribute to ADNKA activity. NK cell education through inhibitory Killer Immunoglobulin‐like Receptors activates antibody‐dependent NK cell functions but mediate antibody‐dependent cellular cytotocitiy no better than their uneducated counterparts.
The engagement of activating NK receptors (aNKR) stimulates NK cell activity, provided that interactions between inhibitory NK receptors (iNKR) with their HLA ligands do not override them. Abs bound to target cells can also activate NK cells by engaging the CD16 aNKR. NK cell education status is an important factor for Ab-dependent NK cell activation (ADNKA) of some NK cell subsets. However, whether NK cell education also influences Ab-dependent cellular cytotoxicity (ADCC) levels is not fully known. ADCC-GranToxiLux (GTL) assays measured ADCC activity as the frequency of granzyme B positive (%GzB+ ) target cells. Target cells were anti-HIV Immunoglobulin G (HIVIG)-opsonized CEM-NKr.CCR5 (CEM) cells. Lymphocytes and sorted single positive (SP) NKG2A+ , KIR2DL1+ , KIR2DL3+ , and KIR3DL1+ NK cells, to self- and nonself HLA, were used as effectors in ADCC-GTL assays to examine how education status influenced ADCC activity. ADNKA activity was assessed by stimulating lymphocytes with HIVIG-opsonized CEMs and measuring the frequency of NK cell populations defined by their expression of iNKRs, along with IFN-γ, CCL4, and CD107a functions. ADCC: the %GzB+ CEM cells generated by self- versus nonself HLA-specific SPiNKR did not differ. ADNKA: More NK cells educated through KIR2DL1 and KIR3DL1, but not KIR2DL3, responded to ADNKA than their uneducated counterparts. CD16 engagement induced ADCC and ADNKA activity. With the proviso that groups' sizes were small, our results support the notion that NK cell education does not influence ADCC levels but does contribute to ADNKA activity.The engagement of activating NK receptors (aNKR) stimulates NK cell activity, provided that interactions between inhibitory NK receptors (iNKR) with their HLA ligands do not override them. Abs bound to target cells can also activate NK cells by engaging the CD16 aNKR. NK cell education status is an important factor for Ab-dependent NK cell activation (ADNKA) of some NK cell subsets. However, whether NK cell education also influences Ab-dependent cellular cytotoxicity (ADCC) levels is not fully known. ADCC-GranToxiLux (GTL) assays measured ADCC activity as the frequency of granzyme B positive (%GzB+ ) target cells. Target cells were anti-HIV Immunoglobulin G (HIVIG)-opsonized CEM-NKr.CCR5 (CEM) cells. Lymphocytes and sorted single positive (SP) NKG2A+ , KIR2DL1+ , KIR2DL3+ , and KIR3DL1+ NK cells, to self- and nonself HLA, were used as effectors in ADCC-GTL assays to examine how education status influenced ADCC activity. ADNKA activity was assessed by stimulating lymphocytes with HIVIG-opsonized CEMs and measuring the frequency of NK cell populations defined by their expression of iNKRs, along with IFN-γ, CCL4, and CD107a functions. ADCC: the %GzB+ CEM cells generated by self- versus nonself HLA-specific SPiNKR did not differ. ADNKA: More NK cells educated through KIR2DL1 and KIR3DL1, but not KIR2DL3, responded to ADNKA than their uneducated counterparts. CD16 engagement induced ADCC and ADNKA activity. With the proviso that groups' sizes were small, our results support the notion that NK cell education does not influence ADCC levels but does contribute to ADNKA activity.
The engagement of activating NK receptors (aNKR) stimulates NK cell activity, provided that interactions between inhibitory NK receptors (iNKR) with their HLA ligands do not override them. Abs bound to target cells can also activate NK cells by engaging the CD16 aNKR. NK cell education status is an important factor for Ab-dependent NK cell activation (ADNKA) of some NK cell subsets. However, whether NK cell education also influences Ab-dependent cellular cytotoxicity (ADCC) levels is not fully known. ADCC-GranToxiLux (GTL) assays measured ADCC activity as the frequency of granzyme B positive (%GzB ) target cells. Target cells were anti-HIV Immunoglobulin G (HIVIG)-opsonized CEM-NKr.CCR5 (CEM) cells. Lymphocytes and sorted single positive (SP) NKG2A , KIR2DL1 , KIR2DL3 , and KIR3DL1 NK cells, to self- and nonself HLA, were used as effectors in ADCC-GTL assays to examine how education status influenced ADCC activity. ADNKA activity was assessed by stimulating lymphocytes with HIVIG-opsonized CEMs and measuring the frequency of NK cell populations defined by their expression of iNKRs, along with IFN-γ, CCL4, and CD107a functions. ADCC: the %GzB CEM cells generated by self- versus nonself HLA-specific SPiNKR did not differ. ADNKA: More NK cells educated through KIR2DL1 and KIR3DL1, but not KIR2DL3, responded to ADNKA than their uneducated counterparts. CD16 engagement induced ADCC and ADNKA activity. With the proviso that groups' sizes were small, our results support the notion that NK cell education does not influence ADCC levels but does contribute to ADNKA activity.
Author Kiani, Zahra
Dupuy, Franck P.
Kant, Sanket
Shoukry, Naglaa H.
Tremblay‐McLean, Alexandra
Isitman, Gamze
Gilbert, Louise
Bernard, Nicole F.
Lebouché, Bertrand
Lisovsky, Irene
Bruneau, Julie
AuthorAffiliation 5 Department of Family Medicine McGill University Montréal Québec Canada
7 Division of Clinical Immunology McGill University Health Centre Montreal Quebec Canada
3 Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) Montreal Quebec Canada
1 Research Institute of the McGill University Health Center (RI‐MUHC) Montreal Quebec Canada
2 Division of Experimental Medicine McGill University Montreal Quebec Canada
4 Department of Family and Emergency Medicine Université de Montréal Montreal Quebec Canada
6 Chronic Viral Illness Service McGill University Health Centre Montreal Quebec Canada
AuthorAffiliation_xml – name: 3 Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) Montreal Quebec Canada
– name: 2 Division of Experimental Medicine McGill University Montreal Quebec Canada
– name: 4 Department of Family and Emergency Medicine Université de Montréal Montreal Quebec Canada
– name: 1 Research Institute of the McGill University Health Center (RI‐MUHC) Montreal Quebec Canada
– name: 5 Department of Family Medicine McGill University Montréal Québec Canada
– name: 6 Chronic Viral Illness Service McGill University Health Centre Montreal Quebec Canada
– name: 7 Division of Clinical Immunology McGill University Health Centre Montreal Quebec Canada
Author_xml – sequence: 1
  givenname: Irene
  surname: Lisovsky
  fullname: Lisovsky, Irene
  organization: McGill University
– sequence: 2
  givenname: Sanket
  surname: Kant
  fullname: Kant, Sanket
  organization: McGill University
– sequence: 3
  givenname: Alexandra
  surname: Tremblay‐McLean
  fullname: Tremblay‐McLean, Alexandra
  organization: McGill University
– sequence: 4
  givenname: Gamze
  surname: Isitman
  fullname: Isitman, Gamze
  organization: McGill University
– sequence: 5
  givenname: Zahra
  surname: Kiani
  fullname: Kiani, Zahra
  organization: McGill University
– sequence: 6
  givenname: Franck P.
  surname: Dupuy
  fullname: Dupuy, Franck P.
  organization: Research Institute of the McGill University Health Center (RI‐MUHC)
– sequence: 7
  givenname: Louise
  surname: Gilbert
  fullname: Gilbert, Louise
  organization: Research Institute of the McGill University Health Center (RI‐MUHC)
– sequence: 8
  givenname: Julie
  surname: Bruneau
  fullname: Bruneau, Julie
  organization: Université de Montréal
– sequence: 9
  givenname: Naglaa H.
  surname: Shoukry
  fullname: Shoukry, Naglaa H.
  organization: Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM)
– sequence: 10
  givenname: Bertrand
  surname: Lebouché
  fullname: Lebouché, Bertrand
  organization: McGill University Health Centre
– sequence: 11
  givenname: Nicole F.
  surname: Bernard
  fullname: Bernard, Nicole F.
  email: nicole.bernard@mcgill.ca
  organization: McGill University Health Centre
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30698860$$D View this record in MEDLINE/PubMed
BookMark eNqFUU1v1DAUtFArul34AVyQj0Vqir9iJxekZZfS0hVIKzhbju10jbLx4jhFe-PSe39jfwlOs0XAAU72e34z4zdzDA5a31oAXmB0hhEirz8s356xGeJYZISR1Wr1BExwSYuMckEPwAQJhrOcIXQEjrvuK0KIEo6egiOKeFkUHE3A7cLVtQ22jU41UPs2Blf10fkW-hpa02v1UMR18P31Gl5drshiiU_3F3oKVWuGgqYujD6V0VXe7O5_3Bm7ta1J1PBktngFP15BbZsGKh3dzcg6YGeL-fwZOKxV09nn-3MKvpy_-zy_yJaf3l_OZ8tMMybyTDGqcFGXmFtuDRcYESMErZgpcNqmIpZqw5lSvKAlw0YrgYnmuarzXJHkzBS8GXm3fbWxRqe_BdXIbXAbFXbSKyf_fGndWl77G8mTJklSU3CyJwj-W2-7KDeuG7ZSrfV9JwkWJROEcZxGX_6u9Uvk0fs0IMYBHXzXBVtL7eKDL0naNRIjOaQsU8pyTFmOKSck_gv5SP4vzF7tu2vs7v-AoYMRRTn9CQUMueA
CitedBy_id crossref_primary_10_1007_s00262_022_03299_x
crossref_primary_10_1097_j_pain_0000000000002498
crossref_primary_10_1097_COH_0000000000000638
crossref_primary_10_1128_JVI_01185_19
crossref_primary_10_3389_fimmu_2022_879124
crossref_primary_10_1016_j_heliyon_2024_e34756
crossref_primary_10_4049_jimmunol_2300197
crossref_primary_10_1080_21505594_2024_2350892
crossref_primary_10_1080_2162402X_2021_1936392
crossref_primary_10_1093_infdis_jiaa698
crossref_primary_10_1128_mBio_02690_19
Cites_doi 10.1172/JCI108240
10.1016/j.it.2009.01.006
10.1186/1742-6405-8-20
10.1371/journal.ppat.1003867
10.1084/jem.153.3.615
10.1038/ng2035
10.1371/journal.pone.0000326
10.4049/jimmunol.134.2.971
10.1126/science.1143767
10.4049/jimmunol.0803945
10.1084/jem.20091010
10.4049/jimmunol.161.2.571
10.1128/JVI.02461-14
10.3389/fimmu.2012.00336
10.1182/blood-2012-06-439851
10.1128/JVI.02146-17
10.1073/pnas.90.24.12000
10.1111/imr.12343
10.1371/journal.pone.0164517
10.1016/j.jviromet.2014.08.003
10.1182/blood-2009-09-245746
10.1128/JVI.02652-10
10.1073/pnas.0712229105
10.1016/j.immuni.2006.06.013
10.1002/eji.1830270517
10.1038/nri2206
10.4049/jimmunol.180.6.3969
10.1007/978-1-60761-362-6_25
10.1016/j.cell.2016.08.005
10.1097/00002030-199111000-00004
10.1182/blood-2008-05-156836
10.1182/blood-2010-04-281675
10.1016/j.cell.2014.01.052
10.1016/j.cell.2014.08.023
10.1016/j.cell.2015.10.027
10.1097/QAD.0000000000000489
10.1084/jem.180.4.1235
10.1089/aid.2016.0157
10.1128/JVI.06112-11
10.4049/jimmunol.0902621
10.1002/cyto.a.21084
10.1126/science.aaf1279
10.1038/nature06106
10.1002/jca.10051
10.1097/QAD.0b013e3282f56b23
10.4049/jimmunol.1100431
10.1038/nature03847
10.4049/jimmunol.137.11.3671
10.1038/35869
10.1038/nature17677
10.1084/jem.20050167
10.1073/pnas.1322052111
10.4049/jimmunol.1700394
10.1126/science.1232685
10.1056/NEJMoa0908492
10.1182/blood-2010-04-282301
10.1371/journal.pone.0011966
10.1097/QAD.0b013e3282ffde7e
10.1371/journal.pcbi.1004185
10.1146/annurev-immunol-041015-055515
10.1182/blood-2004-08-3156
10.1002/(SICI)1521-4141(199809)28:09<2854::AID-IMMU2854>3.0.CO;2-W
10.1126/sciimmunol.aag1672
10.1097/QAD.0000000000000729
10.1111/cei.12752
10.1056/NEJMoa1113425
ContentType Journal Article
Copyright 2019 Society for Leukocyte Biology
2019 Society for Leukocyte Biology.
2018 The Authors. published by Wiley Periodicals, Inc. on behalf of Society for Leukocyte Biology
Copyright_xml – notice: 2019 Society for Leukocyte Biology
– notice: 2019 Society for Leukocyte Biology.
– notice: 2018 The Authors. published by Wiley Periodicals, Inc. on behalf of Society for Leukocyte Biology
DBID 24P
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOI 10.1002/JLB.4A0617-242RRR
DatabaseName Wiley Online Library Open Access
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList
CrossRef

MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: 24P
  name: Wiley Online Library Open Access
  url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
Biology
DocumentTitleAlternate LISOVSKY et al
EISSN 1938-3673
EndPage 563
ExternalDocumentID PMC6916277
30698860
10_1002_JLB_4A0617_242RRR
JLB10305
Genre article
Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Canadian Institutes for Health Research (CIHR)
  funderid: MOP‐123800; MOP‐142494
– fundername: Canadian Institutes for Health Research (CIHR)
  grantid: MOP-142494
– fundername: Canadian Institutes for Health Research (CIHR)
  grantid: MOP-123800
– fundername: Canadian Institutes for Health Research (CIHR)
  grantid: MOP‐123800; MOP‐142494
GroupedDBID ---
.GJ
0R~
0VX
18M
1OB
1OC
24P
29K
2WC
33P
4.4
53G
5GY
5RE
5WD
AABZA
AACZT
AAHHS
AAPGJ
AAPXW
AARHZ
AASGY
AAUAY
AAVAP
AAWDT
AAXRX
AAZKR
ABCUV
ABDFA
ABEFU
ABEJV
ABJNI
ABLJU
ABMNT
ABNHQ
ABPQP
ABPTD
ABWST
ABXVV
ACAHQ
ACCFJ
ACCZN
ACFRR
ACGFO
ACGFS
ACPOU
ACPRK
ACUTJ
ACXBN
ACXQS
ACZBC
ADBBV
ADIPN
ADKYN
ADOZA
ADQBN
ADVEK
ADVOB
ADXAS
ADZMN
AEEZP
AENEX
AEQDE
AFFNX
AFGWE
AFRAH
AFYAG
AGMDO
AGQXC
AHMMS
AI.
AIURR
AIWBW
AJAOE
AJBDE
AJEEA
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AMYDB
ANFBD
APJGH
ATGXG
AVNTJ
BCRHZ
C45
CS3
D-I
DCZOG
DRFUL
DRSTM
DU5
E3Z
EBS
EJD
EMOBN
F5P
F9R
GX1
H13
HZ~
K-O
KOP
L7B
LATKE
LEEKS
LUTES
LYRES
O9-
OBOKY
OCZFY
OJZSN
OK1
OPAEJ
OVD
OWPYF
P2P
P2W
RHI
RJQFR
ROL
ROX
SJN
SUPJJ
TCN
TEORI
TMA
TR2
TSL
VH1
W8F
WOHZO
WOQ
YHG
ZGI
ZXP
ZZTAW
AAYXX
ABGNP
ABVGC
ABXZS
ADGKP
ADNBA
AGORE
AJBYB
AJNCP
ALXQX
CITATION
AAMMB
ABIME
ABPIB
ABZEO
ACVCV
ADMTO
AEFGJ
AFFQV
AGXDD
AHGBF
AIDQK
AIDYY
AJDVS
CGR
CUY
CVF
ECM
EIF
NPM
NU-
OBFPC
7X8
5PM
ID FETCH-LOGICAL-c4475-a43a18f916e6ed67102d773b4d81860b2e3cd64aa683941dca712c65af55a2193
IEDL.DBID 24P
ISSN 0741-5400
1938-3673
IngestDate Thu Aug 21 14:24:49 EDT 2025
Fri Jul 11 10:40:21 EDT 2025
Mon Jul 21 06:02:46 EDT 2025
Tue Jul 01 00:31:56 EDT 2025
Thu Apr 24 22:59:04 EDT 2025
Wed Jan 22 17:00:06 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords Ab-dependent NK cell activation
KIR
NK cell education
ADCC
NKG2A
Language English
License https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
2019 Society for Leukocyte Biology.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4475-a43a18f916e6ed67102d773b4d81860b2e3cd64aa683941dca712c65af55a2193
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://onlinelibrary.wiley.com/doi/abs/10.1002%2FJLB.4A0617-242RRR
PMID 30698860
PQID 2179472461
PQPubID 23479
PageCount 13
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_6916277
proquest_miscellaneous_2179472461
pubmed_primary_30698860
crossref_citationtrail_10_1002_JLB_4A0617_242RRR
crossref_primary_10_1002_JLB_4A0617_242RRR
wiley_primary_10_1002_JLB_4A0617_242RRR_JLB10305
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate March 2019
PublicationDateYYYYMMDD 2019-03-01
PublicationDate_xml – month: 03
  year: 2019
  text: March 2019
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Hoboken
PublicationTitle Journal of leukocyte biology
PublicationTitleAlternate J Leukoc Biol
PublicationYear 2019
Publisher John Wiley and Sons Inc
Publisher_xml – name: John Wiley and Sons Inc
References 2007; 39
2012; 366
1986; 137
2015; 268
2016; 32
1975; 56
2008; 8
2009; 113
2008; 105
2010; 184
2003; 18
2013; 121
2014; 28
2017; 199
2016; 34
2016; 184
2015; 89
2014; 208
2010; 116
1994; 180
1981; 153
2010; 115
2006; 25
2005; 105
1985; 134
2016; 352
2008; 22
2009; 361
2007; 2
2009; 206
2010; 5
1998; 161
2014; 10
2015; 163
1998; 28
2007; 449
2012; 189
2009; 182
2015; 11
2005; 436
2016; 166
1997; 27
2011; 79
1993; 90
2013; 340
2014; 111
2014; 158
2011; 8
2014; 156
1991; 5
2016; 11
2008; 180
1998; 391
1993; 12
2009; 30
2016; 1
2012; 3
2007; 317
2015; 29
2005; 201
2010; 612
2018; 92
2011; 85
2016; 533
2012; 86
Llano (2023032406192246900_jlb10305-cit-0028) 1998; 28
Winter (2023032406192246900_jlb10305-cit-0034) 1998; 161
Bhat (2023032406192246900_jlb10305-cit-0065) 2007; 2
Apps (2023032406192246900_jlb10305-cit-0041) 2013; 340
Parsons (2023032406192246900_jlb10305-cit-0060) 2014; 28
Liu (2023032406192246900_jlb10305-cit-0057) 2014; 111
Isitman (2023032406192246900_jlb10305-cit-0042) 2015; 29
Hilton (2023032406192246900_jlb10305-cit-0063) 2012; 189
Hessell (2023032406192246900_jlb10305-cit-0005) 2007; 449
Moesta (2023032406192246900_jlb10305-cit-0033) 2008; 180
Ullberg (2023032406192246900_jlb10305-cit-0066) 1981; 153
Koup (2023032406192246900_jlb10305-cit-0012) 1991; 5
Bournazos (2023032406192246900_jlb10305-cit-0008) 2014; 158
Anfossi (2023032406192246900_jlb10305-cit-0018) 2006; 25
Colonna (2023032406192246900_jlb10305-cit-0032) 1993; 90
Horowitz (2023032406192246900_jlb10305-cit-0029) 2016; 1
Boulet (2023032406192246900_jlb10305-cit-0038) 2008; 22
Moesta (2023032406192246900_jlb10305-cit-0035) 2012; 3
Kristensen (2023032406192246900_jlb10305-cit-0054) 2018; 92
Braud (2023032406192246900_jlb10305-cit-0027) 1997; 27
West (2023032406192246900_jlb10305-cit-0002) 2014; 156
Fauriat (2023032406192246900_jlb10305-cit-0020) 2010; 115
Choi (2023032406192246900_jlb10305-cit-0016) 2015; 11
Makedonas (2023032406192246900_jlb10305-cit-0047) 2009; 182
Chung (2023032406192246900_jlb10305-cit-0015) 2015; 163
Parsons (2023032406192246900_jlb10305-cit-0062) 2012; 86
Trinchieri (2023032406192246900_jlb10305-cit-0010) 1993; 12
Graef (2023032406192246900_jlb10305-cit-0056) 2009; 206
Fellay (2023032406192246900_jlb10305-cit-0036) 2007; 317
Fernandez (2023032406192246900_jlb10305-cit-0025) 2005; 105
Howell (2023032406192246900_jlb10305-cit-0053) 1985; 134
Kamya (2023032406192246900_jlb10305-cit-0039) 2011; 85
Vanherberghen (2023032406192246900_jlb10305-cit-0067) 2013; 121
Burton (2023032406192246900_jlb10305-cit-0001) 2016; 34
Kim (2023032406192246900_jlb10305-cit-0017) 2005; 436
Pollara (2023032406192246900_jlb10305-cit-0046) 2011; 79
Gooneratne (2023032406192246900_jlb10305-cit-0059) 2016; 184
Gooneratne (2023032406192246900_jlb10305-cit-0061) 2015; 89
Briney (2023032406192246900_jlb10305-cit-0003) 2016; 166
Nimmerjahn (2023032406192246900_jlb10305-cit-0009) 2008; 8
Brodin (2023032406192246900_jlb10305-cit-0019) 2009; 113
Rerks-Ngarm (2023032406192246900_jlb10305-cit-0014) 2009; 361
Kim (2023032406192246900_jlb10305-cit-0024) 2008; 105
Kamya (2023032406192246900_jlb10305-cit-0023) 2011; 8
Martin (2023032406192246900_jlb10305-cit-0037) 2007; 39
Isitman (2023032406192246900_jlb10305-cit-0049) 2016; 11
Beziat (2023032406192246900_jlb10305-cit-0055) 2010; 5
Lopez-Verges (2023032406192246900_jlb10305-cit-0051) 2010; 116
Richard (2023032406192246900_jlb10305-cit-0048) 2014; 208
Isitman (2023032406192246900_jlb10305-cit-0052) 2016; 32
Song (2023032406192246900_jlb10305-cit-0040) 2014; 10
Braud (2023032406192246900_jlb10305-cit-0026) 1998; 391
Netter (2023032406192246900_jlb10305-cit-0064) 2017; 199
Gautam (2023032406192246900_jlb10305-cit-0007) 2016; 533
Boulet (2023032406192246900_jlb10305-cit-0022) 2010; 184
Brier (2023032406192246900_jlb10305-cit-0011) 1975; 56
Wan (2023032406192246900_jlb10305-cit-0031) 1986; 137
Bjorkstrom (2023032406192246900_jlb10305-cit-0050) 2010; 116
Bournazos (2023032406192246900_jlb10305-cit-0006) 2015; 268
Brodin (2023032406192246900_jlb10305-cit-0058) 2009; 30
Boulassel (2023032406192246900_jlb10305-cit-0045) 2003; 18
Johansson (2023032406192246900_jlb10305-cit-0021) 2005; 201
Cella (2023032406192246900_jlb10305-cit-0030) 1994; 180
Haynes (2023032406192246900_jlb10305-cit-0013) 2012; 366
Lu (2023032406192246900_jlb10305-cit-0004) 2016; 352
Kulkarni (2023032406192246900_jlb10305-cit-0044) 2010; 612
Boulet (2023032406192246900_jlb10305-cit-0043) 2008; 22
References_xml – volume: 12
  start-page: 218
  year: 1993
  end-page: 234
  article-title: Receptors for the Fc fragment of IgG on natural killer cells
  publication-title: Nat Immun
– volume: 436
  start-page: 709
  year: 2005
  end-page: 713
  article-title: Licensing of natural killer cells by host major histocompatibility complex class I molecules
  publication-title: Nature
– volume: 25
  start-page: 331
  year: 2006
  end-page: 342
  article-title: Human NK cell education by inhibitory receptors for MHC class I
  publication-title: Immunity
– volume: 8
  start-page: 20
  year: 2011
  article-title: T cell activation does not drive CD4 decline in longitudinally followed HIV‐infected elite controllers
  publication-title: AIDS Res Ther
– volume: 111
  start-page: 2662
  year: 2014
  end-page: 2667
  article-title: Activating killer cell immunoglobulin‐like receptor 2DS2 binds to HLA‐A*11
  publication-title: Proc Natl Acad Sci U S A
– volume: 28
  start-page: 2781
  year: 2014
  end-page: 2786
  article-title: Role of education and differentiation in determining the potential of natural killer cells to respond to antibody‐dependent stimulation
  publication-title: AIDS
– volume: 11
  start-page: e0164517
  year: 2016
  article-title: NK cells expressing the inhibitory killer immunoglobulin‐like receptors (iKIR) KIR2DL1, KIR2DL3 and KIR3DL1 are less likely to be CD16+ than their iKIR negative counterparts
  publication-title: PLoS One
– volume: 317
  start-page: 944
  year: 2007
  end-page: 947
  article-title: A whole‐genome association study of major determinants for host control of HIV‐1
  publication-title: Science
– volume: 30
  start-page: 143
  year: 2009
  end-page: 149
  article-title: NK cell education: not an on‐off switch but a tunable rheostat
  publication-title: Trends Immunol
– volume: 34
  start-page: 635
  year: 2016
  end-page: 659
  article-title: Broadly neutralizing antibodies to HIV and their role in vaccine design
  publication-title: Annu Rev Immunol
– volume: 180
  start-page: 1235
  year: 1994
  end-page: 1242
  article-title: NK3‐specific natural killer cells are selectively inhibited by Bw4‐positive HLA alleles with isoleucine 80
  publication-title: J Exp Med
– volume: 28
  start-page: 2854
  year: 1998
  end-page: 2863
  article-title: HLA‐E‐bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA‐G‐derived nonamer
  publication-title: Eur J Immunol
– volume: 199
  start-page: 2528
  year: 2017
  end-page: 2535
  article-title: Termination of the activating NK cell immunological synapse is an active and regulated process
  publication-title: J Immunol
– volume: 391
  start-page: 795
  year: 1998
  end-page: 799
  article-title: HLA‐E binds to natural killer cell receptors CD94/NKG2A, B and C
  publication-title: Nature
– volume: 189
  start-page: 1418
  year: 2012
  end-page: 1430
  article-title: Mutation at positively selected positions in the binding site for HLA‐C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3
  publication-title: J Immunol
– volume: 206
  start-page: 2557
  year: 2009
  end-page: 2572
  article-title: KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA‐A*11 while diminishing avidity for HLA‐C
  publication-title: J Exp Med
– volume: 612
  start-page: 365
  year: 2010
  end-page: 375
  article-title: KIR genotyping by multiplex PCR‐SSP
  publication-title: Methods Mol Biol
– volume: 22
  start-page: 1487
  year: 2008
  end-page: 1491
  article-title: A combined genotype of KIR3DL1 high expressing alleles and HLA‐B*57 is associated with a reduced risk of HIV infection
  publication-title: AIDS
– volume: 56
  start-page: 1580
  year: 1975
  end-page: 1586
  article-title: Human antibody‐dependent cellular cytotoxicity. Isolation and identification of a subpopulation of peripheral blood lymphocytes which kill antibody‐coated autologous target cells
  publication-title: J Clin Invest
– volume: 116
  start-page: 3853
  year: 2010
  end-page: 3864
  article-title: Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK‐cell differentiation uncoupled from NK‐cell education
  publication-title: Blood
– volume: 115
  start-page: 1166
  year: 2010
  end-page: 1174
  article-title: Education of human natural killer cells by activating killer cell immunoglobulin‐like receptors
  publication-title: Blood
– volume: 161
  start-page: 571
  year: 1998
  end-page: 577
  article-title: Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA‐C allotype recognition
  publication-title: J Immunol
– volume: 79
  start-page: 603
  year: 2011
  end-page: 612
  article-title: High‐throughput quantitative analysis of HIV‐1 and SIV‐specific ADCC‐mediating antibody responses
  publication-title: Cytometry A
– volume: 361
  start-page: 2209
  year: 2009
  end-page: 2220
  article-title: Vaccination with ALVAC and AIDSVAX to prevent HIV‐1 infection in Thailand
  publication-title: N Engl J Med
– volume: 8
  start-page: 34
  year: 2008
  end-page: 47
  article-title: Fcgamma receptors as regulators of immune responses
  publication-title: Nat Rev Immunol
– volume: 92
  year: 2018
  article-title: Contribution of NK cell education to both direct and anti‐HIV‐1 antibody‐dependent NK cell functions
  publication-title: J Virol
– volume: 533
  start-page: 105
  year: 2016
  end-page: 109
  article-title: A single injection of anti‐HIV‐1 antibodies protects against repeated SHIV challenges
  publication-title: Nature
– volume: 449
  start-page: 101
  year: 2007
  end-page: 104
  article-title: Fc receptor but not complement binding is important in antibody protection against HIV
  publication-title: Nature
– volume: 18
  start-page: 55
  year: 2003
  end-page: 60
  article-title: Changes in immunological and virological parameters in HIV‐1 infected subjects following leukapheresis
  publication-title: J Clin Apher
– volume: 163
  start-page: 988
  year: 2015
  end-page: 998
  article-title: Dissecting polyclonal vaccine‐induced humoral immunity against HIV using systems serology
  publication-title: Cell
– volume: 10
  start-page: e1003867
  year: 2014
  article-title: HIV protective KIR3DL1/S1‐HLA‐B genotypes influence NK cell‐mediated inhibition of HIV replication in autologous CD4 targets
  publication-title: PLoS Pathog
– volume: 121
  start-page: 1326
  year: 2013
  end-page: 1334
  article-title: Classification of human natural killer cells based on migration behavior and cytotoxic response
  publication-title: Blood
– volume: 113
  start-page: 2434
  year: 2009
  end-page: 2441
  article-title: The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells
  publication-title: Blood
– volume: 39
  start-page: 733
  year: 2007
  end-page: 740
  article-title: Innate partnership of HLA‐B and KIR3DL1 subtypes against HIV‐1
  publication-title: Nat Genet
– volume: 116
  start-page: 3865
  year: 2010
  end-page: 3874
  article-title: CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK‐cell subset
  publication-title: Blood
– volume: 184
  start-page: 101
  year: 2016
  end-page: 109
  article-title: Functional advantage of educated KIR2DL1(+) natural killer cells for anti‐HIV‐1 antibody‐dependent activation
  publication-title: Clin Exp Immunol
– volume: 89
  start-page: 97
  year: 2015
  end-page: 109
  article-title: Slaying the Trojan horse: natural killer cells exhibit robust anti‐HIV‐1 antibody‐dependent activation and cytolysis against allogeneic T cells
  publication-title: J Virol
– volume: 268
  start-page: 88
  year: 2015
  end-page: 103
  article-title: Fcgamma receptor pathways during active and passive immunization
  publication-title: Immunol Rev
– volume: 27
  start-page: 1164
  year: 1997
  end-page: 1169
  article-title: The human major histocompatibility complex class Ib molecule HLA‐E binds signal sequence‐derived peptides with primary anchor residues at positions 2 and 9
  publication-title: Eur J Immunol
– volume: 2
  start-page: e326
  year: 2007
  article-title: Serial killing of tumor cells by human natural killer cells–enhancement by therapeutic antibodies
  publication-title: PLoS One
– volume: 1
  year: 2016
  article-title: Class I HLA haplotypes form two schools that educate NK cells in different ways
  publication-title: Sci Immunol
– volume: 352
  start-page: 1001
  year: 2016
  end-page: 1004
  article-title: Enhanced clearance of HIV‐1‐infected cells by broadly neutralizing antibodies against HIV‐1 in vivo
  publication-title: Science
– volume: 29
  start-page: 1433
  year: 2015
  end-page: 1443
  article-title: Natural killer cell education does not affect the magnitude of granzyme B delivery to target cells by antibody‐dependent cellular cytotoxicity
  publication-title: AIDS
– volume: 156
  start-page: 633
  year: 2014
  end-page: 648
  article-title: Structural insights on the role of antibodies in HIV‐1 vaccine and therapy
  publication-title: Cell
– volume: 105
  start-page: 3053
  year: 2008
  end-page: 3058
  article-title: HLA alleles determine differences in human natural killer cell responsiveness and potency
  publication-title: Proc Natl Acad Sci U S A
– volume: 86
  start-page: 4488
  year: 2012
  end-page: 4495
  article-title: HIV infection abrogates the functional advantage of natural killer cells educated through KIR3DL1/HLA‐Bw4 interactions to mediate anti‐HIV antibody‐dependent cellular cytotoxicity
  publication-title: J Virol
– volume: 153
  start-page: 615
  year: 1981
  end-page: 628
  article-title: Recycling and target binding capacity of human natural killer cells
  publication-title: J Exp Med
– volume: 180
  start-page: 3969
  year: 2008
  end-page: 3979
  article-title: Synergistic polymorphism at two positions distal to the ligand‐binding site makes KIR2DL2 a stronger receptor for HLA‐C than KIR2DL3
  publication-title: J Immunol
– volume: 137
  start-page: 3671
  year: 1986
  end-page: 3674
  article-title: The primary structure of HLA‐A32 suggests a region involved in formation of the Bw4/Bw6 epitopes
  publication-title: J Immunol
– volume: 32
  start-page: 1079
  year: 2016
  end-page: 1088
  article-title: Antibody‐dependent cellular cytotoxicity activity of effector cells from HIV‐infected elite and viral controllers
  publication-title: AIDS Res Hum Retroviruses
– volume: 105
  start-page: 4416
  year: 2005
  end-page: 4423
  article-title: A subset of natural killer cells achieves self‐tolerance without expressing inhibitory receptors specific for self‐MHC molecules
  publication-title: Blood
– volume: 158
  start-page: 1243
  year: 2014
  end-page: 1253
  article-title: Broadly neutralizing anti‐HIV‐1 antibodies require Fc effector functions for in vivo activity
  publication-title: Cell
– volume: 90
  start-page: 12000
  year: 1993
  end-page: 12004
  article-title: HLA‐C is the inhibitory ligand that determines dominant resistance to lysis by NK1‐ and NK2‐specific natural killer cells
  publication-title: Proc Natl Acad Sci U S A
– volume: 340
  start-page: 87
  year: 2013
  end-page: 91
  article-title: Influence of HLA‐C expression level on HIV control
  publication-title: Science
– volume: 366
  start-page: 1275
  year: 2012
  end-page: 1286
  article-title: Immune‐correlates analysis of an HIV‐1 vaccine efficacy trial
  publication-title: N Engl J Med
– volume: 201
  start-page: 1145
  year: 2005
  end-page: 1155
  article-title: Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules
  publication-title: J Exp Med
– volume: 5
  start-page: 1309
  year: 1991
  end-page: 1314
  article-title: Antibody‐dependent cell‐mediated cytotoxicity directed by a human monoclonal antibody reactive with gp120 of HIV‐1
  publication-title: AIDS
– volume: 184
  start-page: 2057
  year: 2010
  end-page: 2064
  article-title: HIV protective KIR3DL1 and HLA‐B genotypes influence NK cell function following stimulation with HLA‐devoid cells
  publication-title: J Immunol
– volume: 134
  start-page: 971
  year: 1985
  end-page: 976
  article-title: Natural killing target antigens as inducers of interferon: studies with an immunoselected, natural killing‐resistant human T lymphoblastoid cell line
  publication-title: J Immunol
– volume: 11
  start-page: e1004185
  year: 2015
  article-title: Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees
  publication-title: PLoS Comput Biol
– volume: 5
  start-page: e11966
  year: 2010
  article-title: NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs
  publication-title: PLoS One
– volume: 166
  start-page: 1459
  year: 2016
  end-page: 1470
  article-title: Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies
  publication-title: Cell
– volume: 3
  start-page: 336
  year: 2012
  article-title: Diverse functionality among human NK cell receptors for the C1 epitope of HLA‐C: kIR2DS2, KIR2DL2, and KIR2DL3
  publication-title: Front Immunol
– volume: 85
  start-page: 5949
  year: 2011
  end-page: 5960
  article-title: Receptor‐ligand requirements for increased NK cell poly‐functional potential in *h/*y+B57 HIV‐1 infected Slow progressors
  publication-title: J Virol
– volume: 182
  start-page: 5560
  year: 2009
  end-page: 5569
  article-title: Rapid up‐regulation and granule‐independent transport of perforin to the immunological synapse define a novel mechanism of antigen‐specific CD8+ T cell cytotoxic activity
  publication-title: J Immunol
– volume: 208
  start-page: 107
  year: 2014
  end-page: 114
  article-title: Flow cytometry‐based assay to study HIV‐1 gp120 specific antibody‐dependent cellular cytotoxicity responses
  publication-title: J Virol Methods
– volume: 22
  start-page: 595
  year: 2008
  end-page: 599
  article-title: Increased proportion of KIR3DS1 homozygotes in HIV‐exposed uninfected individuals
  publication-title: AIDS
– volume: 56
  start-page: 1580
  year: 1975
  ident: 2023032406192246900_jlb10305-cit-0011
  article-title: Human antibody-dependent cellular cytotoxicity. Isolation and identification of a subpopulation of peripheral blood lymphocytes which kill antibody-coated autologous target cells?
  publication-title: J Clin Invest
  doi: 10.1172/JCI108240
– volume: 30
  start-page: 143
  year: 2009
  ident: 2023032406192246900_jlb10305-cit-0058
  article-title: NK cell education: not an on-off switch but a tunable rheostat?
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2009.01.006
– volume: 8
  start-page: 20
  year: 2011
  ident: 2023032406192246900_jlb10305-cit-0023
  article-title: T cell activation does not drive CD4 decline in longitudinally followed HIV-infected elite controllers?
  publication-title: AIDS Res Ther
  doi: 10.1186/1742-6405-8-20
– volume: 10
  start-page: e1003867
  year: 2014
  ident: 2023032406192246900_jlb10305-cit-0040
  article-title: HIV protective KIR3DL1/S1-HLA-B genotypes influence NK cell-mediated inhibition of HIV replication in autologous CD4 targets?
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1003867
– volume: 153
  start-page: 615
  year: 1981
  ident: 2023032406192246900_jlb10305-cit-0066
  article-title: Recycling and target binding capacity of human natural killer cells?
  publication-title: J Exp Med
  doi: 10.1084/jem.153.3.615
– volume: 39
  start-page: 733
  year: 2007
  ident: 2023032406192246900_jlb10305-cit-0037
  article-title: Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1?
  publication-title: Nat Genet
  doi: 10.1038/ng2035
– volume: 2
  start-page: e326
  year: 2007
  ident: 2023032406192246900_jlb10305-cit-0065
  article-title: Serial killing of tumor cells by human natural killer cells–enhancement by therapeutic antibodies?
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0000326
– volume: 134
  start-page: 971
  year: 1985
  ident: 2023032406192246900_jlb10305-cit-0053
  article-title: Natural killing target antigens as inducers of interferon: studies with an immunoselected, natural killing-resistant human T lymphoblastoid cell line?
  publication-title: J Immunol
  doi: 10.4049/jimmunol.134.2.971
– volume: 317
  start-page: 944
  year: 2007
  ident: 2023032406192246900_jlb10305-cit-0036
  article-title: A whole-genome association study of major determinants for host control of HIV-1?
  publication-title: Science
  doi: 10.1126/science.1143767
– volume: 182
  start-page: 5560
  year: 2009
  ident: 2023032406192246900_jlb10305-cit-0047
  article-title: Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity?
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0803945
– volume: 206
  start-page: 2557
  year: 2009
  ident: 2023032406192246900_jlb10305-cit-0056
  article-title: KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C?
  publication-title: J Exp Med
  doi: 10.1084/jem.20091010
– volume: 161
  start-page: 571
  year: 1998
  ident: 2023032406192246900_jlb10305-cit-0034
  article-title: Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition?
  publication-title: J Immunol
  doi: 10.4049/jimmunol.161.2.571
– volume: 89
  start-page: 97
  year: 2015
  ident: 2023032406192246900_jlb10305-cit-0061
  article-title: Slaying the Trojan horse: natural killer cells exhibit robust anti-HIV-1 antibody-dependent activation and cytolysis against allogeneic T cells?
  publication-title: J Virol
  doi: 10.1128/JVI.02461-14
– volume: 3
  start-page: 336
  year: 2012
  ident: 2023032406192246900_jlb10305-cit-0035
  article-title: Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: kIR2DS2, KIR2DL2, and KIR2DL3?
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2012.00336
– volume: 121
  start-page: 1326
  year: 2013
  ident: 2023032406192246900_jlb10305-cit-0067
  article-title: Classification of human natural killer cells based on migration behavior and cytotoxic response?
  publication-title: Blood
  doi: 10.1182/blood-2012-06-439851
– volume: 92
  year: 2018
  ident: 2023032406192246900_jlb10305-cit-0054
  article-title: Contribution of NK cell education to both direct and anti-HIV-1 antibody-dependent NK cell functions?
  publication-title: J Virol
  doi: 10.1128/JVI.02146-17
– volume: 90
  start-page: 12000
  year: 1993
  ident: 2023032406192246900_jlb10305-cit-0032
  article-title: HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells?
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.90.24.12000
– volume: 268
  start-page: 88
  year: 2015
  ident: 2023032406192246900_jlb10305-cit-0006
  article-title: Fcgamma receptor pathways during active and passive immunization?
  publication-title: Immunol Rev
  doi: 10.1111/imr.12343
– volume: 11
  start-page: e0164517
  year: 2016
  ident: 2023032406192246900_jlb10305-cit-0049
  article-title: NK cells expressing the inhibitory killer immunoglobulin-like receptors (iKIR) KIR2DL1, KIR2DL3 and KIR3DL1 are less likely to be CD16+ than their iKIR negative counterparts?
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0164517
– volume: 208
  start-page: 107
  year: 2014
  ident: 2023032406192246900_jlb10305-cit-0048
  article-title: Flow cytometry-based assay to study HIV-1 gp120 specific antibody-dependent cellular cytotoxicity responses?
  publication-title: J Virol Methods
  doi: 10.1016/j.jviromet.2014.08.003
– volume: 115
  start-page: 1166
  year: 2010
  ident: 2023032406192246900_jlb10305-cit-0020
  article-title: Education of human natural killer cells by activating killer cell immunoglobulin-like receptors?
  publication-title: Blood
  doi: 10.1182/blood-2009-09-245746
– volume: 85
  start-page: 5949
  year: 2011
  ident: 2023032406192246900_jlb10305-cit-0039
  article-title: Receptor-ligand requirements for increased NK cell poly-functional potential in *h/*y+B57 HIV-1 infected Slow progressors?
  publication-title: J Virol
  doi: 10.1128/JVI.02652-10
– volume: 105
  start-page: 3053
  year: 2008
  ident: 2023032406192246900_jlb10305-cit-0024
  article-title: HLA alleles determine differences in human natural killer cell responsiveness and potency?
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0712229105
– volume: 25
  start-page: 331
  year: 2006
  ident: 2023032406192246900_jlb10305-cit-0018
  article-title: Human NK cell education by inhibitory receptors for MHC class I?
  publication-title: Immunity
  doi: 10.1016/j.immuni.2006.06.013
– volume: 27
  start-page: 1164
  year: 1997
  ident: 2023032406192246900_jlb10305-cit-0027
  article-title: The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9?
  publication-title: Eur J Immunol
  doi: 10.1002/eji.1830270517
– volume: 8
  start-page: 34
  year: 2008
  ident: 2023032406192246900_jlb10305-cit-0009
  article-title: Fcgamma receptors as regulators of immune responses?
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2206
– volume: 180
  start-page: 3969
  year: 2008
  ident: 2023032406192246900_jlb10305-cit-0033
  article-title: Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3?
  publication-title: J Immunol
  doi: 10.4049/jimmunol.180.6.3969
– volume: 612
  start-page: 365
  year: 2010
  ident: 2023032406192246900_jlb10305-cit-0044
  article-title: KIR genotyping by multiplex PCR-SSP?
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-60761-362-6_25
– volume: 166
  start-page: 1459
  year: 2016
  ident: 2023032406192246900_jlb10305-cit-0003
  article-title: Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies?
  publication-title: Cell
  doi: 10.1016/j.cell.2016.08.005
– volume: 5
  start-page: 1309
  year: 1991
  ident: 2023032406192246900_jlb10305-cit-0012
  article-title: Antibody-dependent cell-mediated cytotoxicity directed by a human monoclonal antibody reactive with gp120 of HIV-1?
  publication-title: AIDS
  doi: 10.1097/00002030-199111000-00004
– volume: 113
  start-page: 2434
  year: 2009
  ident: 2023032406192246900_jlb10305-cit-0019
  article-title: The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells?
  publication-title: Blood
  doi: 10.1182/blood-2008-05-156836
– volume: 116
  start-page: 3853
  year: 2010
  ident: 2023032406192246900_jlb10305-cit-0050
  article-title: Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education?
  publication-title: Blood
  doi: 10.1182/blood-2010-04-281675
– volume: 156
  start-page: 633
  year: 2014
  ident: 2023032406192246900_jlb10305-cit-0002
  article-title: Structural insights on the role of antibodies in HIV-1 vaccine and therapy?
  publication-title: Cell
  doi: 10.1016/j.cell.2014.01.052
– volume: 158
  start-page: 1243
  year: 2014
  ident: 2023032406192246900_jlb10305-cit-0008
  article-title: Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity?
  publication-title: Cell
  doi: 10.1016/j.cell.2014.08.023
– volume: 163
  start-page: 988
  year: 2015
  ident: 2023032406192246900_jlb10305-cit-0015
  article-title: Dissecting polyclonal vaccine-induced humoral immunity against HIV using systems serology?
  publication-title: Cell
  doi: 10.1016/j.cell.2015.10.027
– volume: 28
  start-page: 2781
  year: 2014
  ident: 2023032406192246900_jlb10305-cit-0060
  article-title: Role of education and differentiation in determining the potential of natural killer cells to respond to antibody-dependent stimulation?
  publication-title: AIDS
  doi: 10.1097/QAD.0000000000000489
– volume: 180
  start-page: 1235
  year: 1994
  ident: 2023032406192246900_jlb10305-cit-0030
  article-title: NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80?
  publication-title: J Exp Med
  doi: 10.1084/jem.180.4.1235
– volume: 32
  start-page: 1079
  year: 2016
  ident: 2023032406192246900_jlb10305-cit-0052
  article-title: Antibody-dependent cellular cytotoxicity activity of effector cells from HIV-infected elite and viral controllers?
  publication-title: AIDS Res Hum Retroviruses
  doi: 10.1089/aid.2016.0157
– volume: 86
  start-page: 4488
  year: 2012
  ident: 2023032406192246900_jlb10305-cit-0062
  article-title: HIV infection abrogates the functional advantage of natural killer cells educated through KIR3DL1/HLA-Bw4 interactions to mediate anti-HIV antibody-dependent cellular cytotoxicity?
  publication-title: J Virol
  doi: 10.1128/JVI.06112-11
– volume: 184
  start-page: 2057
  year: 2010
  ident: 2023032406192246900_jlb10305-cit-0022
  article-title: HIV protective KIR3DL1 and HLA-B genotypes influence NK cell function following stimulation with HLA-devoid cells?
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0902621
– volume: 79
  start-page: 603
  year: 2011
  ident: 2023032406192246900_jlb10305-cit-0046
  article-title: High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses?
  publication-title: Cytometry A
  doi: 10.1002/cyto.a.21084
– volume: 352
  start-page: 1001
  year: 2016
  ident: 2023032406192246900_jlb10305-cit-0004
  article-title: Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo?
  publication-title: Science
  doi: 10.1126/science.aaf1279
– volume: 449
  start-page: 101
  year: 2007
  ident: 2023032406192246900_jlb10305-cit-0005
  article-title: Fc receptor but not complement binding is important in antibody protection against HIV?
  publication-title: Nature
  doi: 10.1038/nature06106
– volume: 18
  start-page: 55
  year: 2003
  ident: 2023032406192246900_jlb10305-cit-0045
  article-title: Changes in immunological and virological parameters in HIV-1 infected subjects following leukapheresis?
  publication-title: J Clin Apher
  doi: 10.1002/jca.10051
– volume: 22
  start-page: 595
  year: 2008
  ident: 2023032406192246900_jlb10305-cit-0043
  article-title: Increased proportion of KIR3DS1 homozygotes in HIV-exposed uninfected individuals?
  publication-title: AIDS
  doi: 10.1097/QAD.0b013e3282f56b23
– volume: 189
  start-page: 1418
  year: 2012
  ident: 2023032406192246900_jlb10305-cit-0063
  article-title: Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3?
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1100431
– volume: 436
  start-page: 709
  year: 2005
  ident: 2023032406192246900_jlb10305-cit-0017
  article-title: Licensing of natural killer cells by host major histocompatibility complex class I molecules?
  publication-title: Nature
  doi: 10.1038/nature03847
– volume: 137
  start-page: 3671
  year: 1986
  ident: 2023032406192246900_jlb10305-cit-0031
  article-title: The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes?
  publication-title: J Immunol
  doi: 10.4049/jimmunol.137.11.3671
– volume: 391
  start-page: 795
  year: 1998
  ident: 2023032406192246900_jlb10305-cit-0026
  article-title: HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C?
  publication-title: Nature
  doi: 10.1038/35869
– volume: 533
  start-page: 105
  year: 2016
  ident: 2023032406192246900_jlb10305-cit-0007
  article-title: A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges?
  publication-title: Nature
  doi: 10.1038/nature17677
– volume: 201
  start-page: 1145
  year: 2005
  ident: 2023032406192246900_jlb10305-cit-0021
  article-title: Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules?
  publication-title: J Exp Med
  doi: 10.1084/jem.20050167
– volume: 111
  start-page: 2662
  year: 2014
  ident: 2023032406192246900_jlb10305-cit-0057
  article-title: Activating killer cell immunoglobulin-like receptor 2DS2 binds to HLA-A*11?
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1322052111
– volume: 199
  start-page: 2528
  year: 2017
  ident: 2023032406192246900_jlb10305-cit-0064
  article-title: Termination of the activating NK cell immunological synapse is an active and regulated process?
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1700394
– volume: 340
  start-page: 87
  year: 2013
  ident: 2023032406192246900_jlb10305-cit-0041
  article-title: Influence of HLA-C expression level on HIV control?
  publication-title: Science
  doi: 10.1126/science.1232685
– volume: 361
  start-page: 2209
  year: 2009
  ident: 2023032406192246900_jlb10305-cit-0014
  article-title: Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand?
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa0908492
– volume: 116
  start-page: 3865
  year: 2010
  ident: 2023032406192246900_jlb10305-cit-0051
  article-title: CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset?
  publication-title: Blood
  doi: 10.1182/blood-2010-04-282301
– volume: 5
  start-page: e11966
  year: 2010
  ident: 2023032406192246900_jlb10305-cit-0055
  article-title: NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs?
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0011966
– volume: 22
  start-page: 1487
  year: 2008
  ident: 2023032406192246900_jlb10305-cit-0038
  article-title: A combined genotype of KIR3DL1 high expressing alleles and HLA-B*57 is associated with a reduced risk of HIV infection?
  publication-title: AIDS
  doi: 10.1097/QAD.0b013e3282ffde7e
– volume: 11
  start-page: e1004185
  year: 2015
  ident: 2023032406192246900_jlb10305-cit-0016
  article-title: Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees?
  publication-title: PLoS Comput Biol
  doi: 10.1371/journal.pcbi.1004185
– volume: 34
  start-page: 635
  year: 2016
  ident: 2023032406192246900_jlb10305-cit-0001
  article-title: Broadly neutralizing antibodies to HIV and their role in vaccine design?
  publication-title: Annu Rev Immunol
  doi: 10.1146/annurev-immunol-041015-055515
– volume: 12
  start-page: 218
  year: 1993
  ident: 2023032406192246900_jlb10305-cit-0010
  article-title: Receptors for the Fc fragment of IgG on natural killer cells?
  publication-title: Nat Immun
– volume: 105
  start-page: 4416
  year: 2005
  ident: 2023032406192246900_jlb10305-cit-0025
  article-title: A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules?
  publication-title: Blood
  doi: 10.1182/blood-2004-08-3156
– volume: 28
  start-page: 2854
  year: 1998
  ident: 2023032406192246900_jlb10305-cit-0028
  article-title: HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer?
  publication-title: Eur J Immunol
  doi: 10.1002/(SICI)1521-4141(199809)28:09<2854::AID-IMMU2854>3.0.CO;2-W
– volume: 1
  year: 2016
  ident: 2023032406192246900_jlb10305-cit-0029
  article-title: Class I HLA haplotypes form two schools that educate NK cells in different ways?
  publication-title: Sci Immunol
  doi: 10.1126/sciimmunol.aag1672
– volume: 29
  start-page: 1433
  year: 2015
  ident: 2023032406192246900_jlb10305-cit-0042
  article-title: Natural killer cell education does not affect the magnitude of granzyme B delivery to target cells by antibody-dependent cellular cytotoxicity?
  publication-title: AIDS
  doi: 10.1097/QAD.0000000000000729
– volume: 184
  start-page: 101
  year: 2016
  ident: 2023032406192246900_jlb10305-cit-0059
  article-title: Functional advantage of educated KIR2DL1(+) natural killer cells for anti-HIV-1 antibody-dependent activation?
  publication-title: Clin Exp Immunol
  doi: 10.1111/cei.12752
– volume: 366
  start-page: 1275
  year: 2012
  ident: 2023032406192246900_jlb10305-cit-0013
  article-title: Immune-correlates analysis of an HIV-1 vaccine efficacy trial?
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1113425
SSID ssj0003260
Score 2.366202
Snippet The engagement of activating NK receptors (aNKR) stimulates NK cell activity, provided that interactions between inhibitory NK receptors (iNKR) with their HLA...
SourceID pubmedcentral
proquest
pubmed
crossref
wiley
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 551
SubjectTerms Ab‐dependent NK cell activation
ADCC
Antibodies - pharmacology
Antibody-Dependent Cell Cytotoxicity - immunology
Fluorescence
Granzymes - metabolism
Host Defense & Pathophysiology
Humans
Killer Cells, Natural - immunology
KIR
Lymphocyte Activation - immunology
NK cell education
NKG2A
Perforin - metabolism
Receptors, KIR2DL1 - metabolism
Receptors, KIR2DL3 - metabolism
Receptors, KIR3DL1 - metabolism
Title Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody‐dependent (AD) NK cell activation and ADCC
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2FJLB.4A0617-242RRR
https://www.ncbi.nlm.nih.gov/pubmed/30698860
https://www.proquest.com/docview/2179472461
https://pubmed.ncbi.nlm.nih.gov/PMC6916277
Volume 105
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1La9wwEB6SlEAupc2rmz5QIJQmxMlalh97dHebNyEsCezNyJJMA6kdGuewt15672_sL-mMZLtdFhJ6MX5J2B7P6JM0-j6AHQyKA601pQ0G3COVIy8XvvGEUjrUOpGIkSjb4jI6uRFnk3CyAMN2LYzjh-gG3MgzbLwmB5f5w-Ff0tCzi88HIqUWmKY1x-PxIrygJbZEoM_FVReOEZ_0HRenT1kA3dRmnx_OVTHbOM0hzvnEyX8BrW2Rjl7BywZKstTZ_jUsmHIV1tISu9Hfpuwjs8mddtR8FZad5uR0DX6OGkkUdO07ZjPVG8krVhXMtPkerBHwYeenYz668PebnWCfyVLTQYBnWV3hYX2bV3r6-8evVlG3Zp_S0S67PGc0L8Bo7YQb-bVl09FwuA43R1-uhydeo8XgKaIE9KQIpJ8UCCZNZHREuETHcZALTZR4_ZybQOlISBkh4hK-VjL2uYpCWYShxKgYbMBSWZXmDbAwQcyE3UYVJKHgcS5zDP680FwXJMyoetBvjZCphqic9DLuMkexzDO0W-bsljm79WCvK3LvWDqeunm7tWyGvkQfQpamenzIOEWnmBj2erDpLN1Vh12rQYJv2oN45h_obiCe7tkr5e1Xy9cd4VfjcYzvZf-W55-QzpD8W7j1_0XewgpiuoFLk3sHS_X3R_MecVOdf7B-gdvjif8Hpt0NdA
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Nb9QwEB2VIkQvFbR8bPkyEkKAGrpxnDh7DBuqbXdZoVUr9RY5sSMqtQmi6WFvvXDnN_JLmLGTwGolELc4iaM4kxk_2-P3AF5hUBxprSltMOAeqRx5ufCNJ4pCh1rHCjESZVvMo8mpOD4LzzYg7fbCOH6IfsKNPMPGa3JwmpA--M0aejz78F4k1AXTuuZisbgFt0XEJbknF5_7eIwAZejIOH1KA-jXNof8YO0Rq73TGuRcz5z8E9HaLunwHmy3WJIlzvj3YcNUO7CbVDiOvlyy18xmd9pp8x2440Qnl7vwPW01UdC3L5hNVW81r1hdMtMlfLBWwYdNjxY8nfn77UGwz1SlqRDgWdbUWGzO81ovf9786CR1G_YmSd-y-ZTRwgCjzRNu6tfWTdLx-AGcHn48GU-8VozBK4gT0FMiUH5cIpo0kdERARMtZZALTZx4w5yboNCRUCpCyCV8XSjp8yIKVRmGCsNi8BA2q7oyj4GFMYImHDcWQRwKLnOVY_Tnpea6JGXGYgDDzghZ0TKVk2DGReY4lnmGdsuc3TJntwG866t8dTQdf7v5ZWfZDJ2JPoSqTH19lXEKT5Io9gbwyFm6fxyOrUYxtnQAcuUf6G8gou7VK9X5F0vYHeFX41Jiu-zf8u83pDOk_xbu_X-VF3B3cvJpls2O5tMnsIUAb-Ry5p7CZvPt2jxDENXkz62P_ALbtw_v
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Nb9QwEB2VIlAvCFqgy6eREALU0I3jfOwxbFi13dWqWlGpt8ixHbVSm1SQHvbWS-_8Rn4JM3YSWK0E4hYncRRnMuNne_wewFsMiiOtNaUNBtwjlSOvEL7xhFI61DqRiJEo22IeHZyIo9PwdAPG3V4Yxw_RT7iRZ9h4TQ5-pcv936ShR7PPn0RKPTAtay4Wiztw1y76Eb2zOO7DMeKToePi9CkLoF_aHPL9tUesdk5riHM9cfJPQGt7pMlDeNBCSZY62z-CDVNtw05a4TD6csneMZvcaWfNt-Ge05xc7sBt1kqioGtfMJup3kpesbpkpsv3YK2AD5seLng28_fag2CPyUpTIcCzrKmx2JwXtV7-vPnRKeo27H2afWDzKaN1AUZ7J9zMr62bZuPxYziZfPk6PvBaLQZPESWgJ0Ug_aREMGkioyPCJTqOg0JoosQbFtwESkdCyggRl_C1krHPVRTKMgwlRsXgCWxWdWV2gYUJYiYcNqogCQWPC1lg8Oel5rokYUY1gGFnhFy1ROWkl3GRO4plnqPdcme33NltAB_7KleOpeNvN7_pLJujL9GHkJWpr7_nnKJTTAx7A3jqLN0_DodWowRbOoB45R_obyCe7tUr1fmZ5euO8KvxOMZ22b_l329IZ0j-LXz2_1Vew_3jbJLPDufT57CF8G7kMuZewGbz7dq8RAjVFK-si_wCMIIPIQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Differential+contribution+of+education+through+KIR2DL1%2C+KIR2DL3%2C+and+KIR3DL1+to+antibody-dependent+%28AD%29+NK+cell+activation+and+ADCC&rft.jtitle=Journal+of+leukocyte+biology&rft.au=Lisovsky%2C+Irene&rft.au=Kant%2C+Sanket&rft.au=Tremblay-McLean%2C+Alexandra&rft.au=Isitman%2C+Gamze&rft.date=2019-03-01&rft.eissn=1938-3673&rft.volume=105&rft.issue=3&rft.spage=551&rft_id=info:doi/10.1002%2FJLB.4A0617-242RRR&rft_id=info%3Apmid%2F30698860&rft.externalDocID=30698860
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0741-5400&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0741-5400&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0741-5400&client=summon