A patient with paroxysmal nocturnal haemoglobinuria in whom granulocyte colony‐stimulating factor administration resulted in improvement of recurrent enterocolitis and its associated haemolytic attacks

• Published in: British journal of haematology Vol. 119; no. 3; pp. 858 - 862
• Main Authors: Fujimi, Akihito, Matsunaga, Takuya, Kogawa, Katsuhisa, Ohnuma, Takayuki, Takahira, Naoki, Abe, Tomoyuki, Kitaoka, Keisuke, Kogawa, Takahiro, Tanaka, Ikuta, Morii, Kazuhiro, Terui, Takeshi, Sakamaki, Sumio, Kato, Junji, Kura, Toshiro, Maeda, Takeshi, Niitsu, Yoshiro
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.12.2002; Blackwell
• Subjects: Aged; Anemias. Hemoglobinopathies; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; cellular immunodeficiency; Diseases of red blood cells; Enterocolitis - prevention & control; Female; Granulocyte Colony-Stimulating Factor - therapeutic use; granulocyte colony‐stimulating factor (G‐CSF); Hematologic and hematopoietic diseases; Hemoglobinuria, Paroxysmal - drug therapy; Humans; Lymphopenia - drug therapy; Lymphopenia - etiology; Medical sciences; paroxysmal nocturnal haemoglobinuria (PNH); Pharmacology. Drug treatments; Secondary Prevention; T-Lymphocytes; Human; Hemolysis; Immunopathology; Erythrocytic membrane disease; Cytokine; Hemopathy; Cellular immunity; granulocyte colony-stimulating factor (G-CSF); Recurrent; Enterocolitis; Immune deficiency; Case study; Chemotherapy; Granulocyte colony stimulating factor; Nocturnal paroxystic anemia; Treatment; cellular immunodeficiency; Polypeptide; Digestive diseases; Intestinal disease; Complication; Female; paroxysmal nocturnal haemoglobinuria (PNH); Elderly
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1046/j.1365-2141.2002.03914.x

We report an elderly patient with paroxysmal nocturnal haemoglobinuria (PNH), having recurrent enterocolitis and haemolytic attacks associated with cellular immunodeficiency. On admission, the patient had normal neutrophil count and function but a decreased T‐cell count, decreased mitogenic reactions, and a negative tuberculin test. Granulocyte colony‐stimulating factor (G‐CSF) was administered, resulting in an increased T‐cell count, normalization of T‐cell function, increased blood levels of helper T cell (Th)1 and Th2 cytokines and improvement in the enterocolitis and haemolytic attacks. This suggests that G‐CSF may be useful in the treatment of elderly PNH patients with cellular immunodeficiency.