miR‐124‐3p increases in high glucose induced osteocyte‐derived exosomes and regulates galectin‐3 expression: A possible mechanism in bone remodeling alteration in diabetic periodontitis

• Published in: The FASEB journal Vol. 34; no. 11; pp. 14234 - 14249
• Main Authors: Li, Jun, Guo, Yue, Chen, Ying‐Yi, Liu, Qiong, Chen, Yun, Tan, Li, Zhang, Shao‐Hui, Gao, Zheng‐Rong, Zhou, Ying‐Hui, Zhang, Gui‐Ying, Feng, Yun‐Zhi
• Format: Journal Article
• Language: English
• Published: United States 01.11.2020
• Subjects: Adult; Aged; Aged, 80 and over; alveolar bone; Alveolar Bone Loss - etiology; Alveolar Bone Loss - metabolism; Alveolar Bone Loss - pathology; Animals; Bone Remodeling; diabetes mellitus; Diabetes Mellitus, Experimental - physiopathology; Diabetes Mellitus, Type 2 - physiopathology; Exosomes - drug effects; Exosomes - genetics; Exosomes - metabolism; Female; Galectin 3 - genetics; Galectin 3 - metabolism; Gene Expression Regulation; Glucose - pharmacology; Humans; inflammation; Male; MicroRNAs - genetics; Middle Aged; osteoblast; Osteoblasts - drug effects; Osteoblasts - metabolism; Osteoblasts - pathology; Periodontitis - complications; Periodontitis - pathology; Rats; Rats, Sprague-Dawley; saliva; alveolar bone; saliva; diabetes mellitus; osteoblast; inflammation

The mechanisms underlying the two‐way relationship between diabetes mellitus (DM) and periodontitis are unclear. We examined a possible effect of galectin‐3 (Gal‐3), a factor in DM and bone metabolism, on periodontitis with or without DM. Using enzyme‐linked immunosorbent assay, we detected saliva G...