Pathological Ventricular Remodeling: Mechanisms: Part 1 of 2

Despite declines in heart failure morbidity and mortality with current therapies, rehospitalization rates remain distressingly high, substantially affecting individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related...

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Published in	Circulation (New York, N.Y.) Vol. 128; no. 4; pp. 388 - 400
Main Authors	Burchfield, Jana S., Xie, Min, Hill, Joseph A.
Format	Journal Article
Language	English
Published	Hagerstown, MD by the American College of Cardiology Foundation and the American Heart Association, Inc 23.07.2013 Lippincott Williams & Wilkins
Subjects	Animals Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiomegaly - pathology Cardiomegaly - physiopathology Cardiomegaly - therapy Disease Progression Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Heart Failure - pathology Heart Failure - physiopathology Heart Failure - therapy Humans Medical sciences Myocardium - pathology Ventricular Remodeling - physiology Heart cardiac electrophysiology stem cells Stem cell Electrophysiology ventricular remodeling Cardiovascular disease Inflammation Mechanism Vascular remodeling Fibrosis Circulatory system Cardiology fibrosis inflammation
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Abstract	Despite declines in heart failure morbidity and mortality with current therapies, rehospitalization rates remain distressingly high, substantially affecting individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related left ventricular remodeling is a complex process involving cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and electrophysiological remodeling. Because these events are highly interrelated, targeting a single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling.
AbstractList	Despite declines in heart failure morbidity and mortality with current therapies, rehospitalization rates remain distressingly high, substantially affecting individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related left ventricular remodeling is a complex process involving cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and electrophysiological remodeling. Because these events are highly interrelated, targeting a single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling. Despite declines in heart failure morbidity and mortality with current therapies, re-hospitalization rates remain distressingly high, impacting substantially on individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related left ventricular remodeling is a complex process involving cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and electrophysiological remodeling. As these events are highly inter-related, targeting one single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling. Despite declines in heart failure morbidity and mortality with current therapies, rehospitalization rates remain distressingly high, substantially affecting individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related left ventricular remodeling is a complex process involving cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and electrophysiological remodeling. Because these events are highly interrelated, targeting a single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling.Despite declines in heart failure morbidity and mortality with current therapies, rehospitalization rates remain distressingly high, substantially affecting individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related left ventricular remodeling is a complex process involving cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and electrophysiological remodeling. Because these events are highly interrelated, targeting a single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling.
Author	Xie, Min Hill, Joseph A. Burchfield, Jana S.
AuthorAffiliation	From the Texas Heart Institute, Houston, TX (J.B.); and Departments of Internal Medicine (Cardiology) (M.X., J.A.H.) and Molecular Biology (J.A.H.), University of Texas Southwestern Medical Center, Dallas
AuthorAffiliation_xml	– name: From the Texas Heart Institute, Houston, TX (J.B.); and Departments of Internal Medicine (Cardiology) (M.X., J.A.H.) and Molecular Biology (J.A.H.), University of Texas Southwestern Medical Center, Dallas – name: 2 Dept of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX – name: 1 Depts of Internal Medicine (Cardiology)
Author_xml	– sequence: 1 givenname: Jana surname: Burchfield middlename: S. fullname: Burchfield, Jana S. organization: From the Texas Heart Institute, Houston, TX (J.B.); and Departments of Internal Medicine (Cardiology) (M.X., J.A.H.) and Molecular Biology (J.A.H.), University of Texas Southwestern Medical Center, Dallas – sequence: 2 givenname: Min surname: Xie fullname: Xie, Min – sequence: 3 givenname: Joseph surname: Hill middlename: A. fullname: Hill, Joseph A.
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27569139$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/23877061$$D View this record in MEDLINE/PubMed
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Keywords	Heart cardiac electrophysiology stem cells Stem cell Electrophysiology ventricular remodeling Cardiovascular disease Inflammation Mechanism Vascular remodeling Fibrosis Circulatory system Cardiology fibrosis inflammation
Language	English
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PublicationDate	2013-July-23
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PublicationDate_xml	– month: 07 year: 2013 text: 2013-July-23 day: 23
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PublicationPlace	Hagerstown, MD
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PublicationTitle	Circulation (New York, N.Y.)
PublicationTitleAlternate	Circulation
PublicationYear	2013
Publisher	by the American College of Cardiology Foundation and the American Heart Association, Inc Lippincott Williams & Wilkins
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Snippet	Despite declines in heart failure morbidity and mortality with current therapies, rehospitalization rates remain distressingly high, substantially affecting... Despite declines in heart failure morbidity and mortality with current therapies, re-hospitalization rates remain distressingly high, impacting substantially...
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SubjectTerms	Animals Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiomegaly - pathology Cardiomegaly - physiopathology Cardiomegaly - therapy Disease Progression Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Heart Failure - pathology Heart Failure - physiopathology Heart Failure - therapy Humans Medical sciences Myocardium - pathology Ventricular Remodeling - physiology
Title	Pathological Ventricular Remodeling: Mechanisms: Part 1 of 2
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