Pathological Ventricular Remodeling: Mechanisms: Part 1 of 2

• Published in: Circulation (New York, N.Y.) Vol. 128; no. 4; pp. 388 - 400
• Main Authors: Burchfield, Jana S., Xie, Min, Hill, Joseph A.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD by the American College of Cardiology Foundation and the American Heart Association, Inc 23.07.2013; Lippincott Williams & Wilkins
• Subjects: Animals; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiomegaly - pathology; Cardiomegaly - physiopathology; Cardiomegaly - therapy; Disease Progression; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Heart Failure - pathology; Heart Failure - physiopathology; Heart Failure - therapy; Humans; Medical sciences; Myocardium - pathology; Ventricular Remodeling - physiology; Heart; cardiac electrophysiology; stem cells; Stem cell; Electrophysiology; ventricular remodeling; Cardiovascular disease; Inflammation; Mechanism; Vascular remodeling; Fibrosis; Circulatory system; Cardiology; fibrosis; inflammation
• ISSN: 0009-7322; 1524-4539; 1524-4539
• DOI: 10.1161/CIRCULATIONAHA.113.001878

Despite declines in heart failure morbidity and mortality with current therapies, rehospitalization rates remain distressingly high, substantially affecting individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related left ventricular remodeling is a complex process involving cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and electrophysiological remodeling. Because these events are highly interrelated, targeting a single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling.