Long‐term use of proton pump inhibitors and vitamin B12 status in elderly individuals

• Published in: Alimentary pharmacology & therapeutics Vol. 27; no. 6; pp. 491 - 497
• Main Authors: DEN ELZEN, W. P. J., GROENEVELD, Y., DE RUIJTER, W., SOUVERIJN, J. H. M., LE CESSIE, S., ASSENDELFT, W. J. J., GUSSEKLOO, J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 15.03.2008; Blackwell
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Digestive system; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Male; Medical sciences; Netherlands; Pharmacology. Drug treatments; Proton Pump Inhibitors; Proton Pumps - adverse effects; Stomach Diseases - drug therapy; Time Factors; Vitamin B 12 - blood; Vitamin B 12 Deficiency - chemically induced; Netherlands; Human; B-Vitamins; Long term; Elderly; Cyanocobalamin; Proton pump inhibitor

Summary Background  Some studies have shown that short‐term use of proton pump inhibitors decreases the absorption of vitamin B12, but the results of studies into long‐term proton pump inhibitor use and vitamin B12 deficiency are inconsistent. Aim  To investigate whether long‐term proton pump inhibi...