Low-dose nitroglycerin improves microcirculation in hospitalized patients with acute heart failure

• Published in: European journal of heart failure Vol. 11; no. 4; pp. 386 - 390
• Main Authors: den Uil, Corstiaan A., Lagrand, Wim K., Spronk, Peter E., van der Ent, Martin, Jewbali, Lucia S.D., Brugts, Jasper J., Ince, Can, Simoons, Maarten L.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.04.2009; Oxford University Press
• Subjects: Acute Disease; Acute heart failure; Aged; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heart Failure - drug therapy; Heart Failure - physiopathology; Humans; Infusions, Intravenous; Inpatients; Male; Microcirculation; Microcirculation - drug effects; Microcirculation - physiology; Middle Aged; Nitroglycerin; Nitroglycerin - administration & dosage; Perfusion; Side-stream dark field imaging; Treatment Outcome; Vasodilator Agents - administration & dosage; Ventricular Pressure - drug effects; Ventricular Pressure - physiology; Microcirculation; Side-stream dark field imaging; Perfusion; Nitroglycerin; Acute heart failure

Aims Impaired tissue perfusion is often observed in patients with acute heart failure. We tested whether low-dose nitroglycerin (NTG) improves microcirculatory perfusion in patients admitted for acute heart failure. Methods and results In 20 acute heart failure patients, NTG was given as intravenous...