In vivo measurement of shear modulus of the human cornea using optical coherence elastography
Corneal stiffness plays a critical role in shaping the cornea with respect to intraocular pressure and physical interventions. However, it remains difficult to measure the mechanical properties noninvasively. Here, we report the first measurement of shear modulus in human corneas in vivo using optic...
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| Published in | Scientific reports Vol. 10; no. 1; p. 17366 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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London
Nature Publishing Group UK
15.10.2020
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| Abstract | Corneal stiffness plays a critical role in shaping the cornea with respect to intraocular pressure and physical interventions. However, it remains difficult to measure the mechanical properties noninvasively. Here, we report the first measurement of shear modulus in human corneas in vivo using optical coherence elastography (OCE) based on surface elastic waves. In a pilot study of 12 healthy subjects aged between 25 and 67, the Rayleigh-wave speed was 7.86 ± 0.75 m/s, corresponding to a shear modulus of 72 ± 14 kPa. Our data reveal two unexpected trends: no correlation was found between the wave speed and IOP between 13–18 mmHg, and shear modulus decreases with age (− 0.32 ± 0.17 m/s per decade). We propose that shear stiffness is governed by the interfibrillar matrix, whereas tensile strength is dominated by collagen fibrils. Rayleigh-wave OCE may prove useful for clinical diagnosis, refractive surgeries, and treatment monitoring. |
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| AbstractList | Corneal stiffness plays a critical role in shaping the cornea with respect to intraocular pressure and physical interventions. However, it remains difficult to measure the mechanical properties noninvasively. Here, we report the first measurement of shear modulus in human corneas in vivo using optical coherence elastography (OCE) based on surface elastic waves. In a pilot study of 12 healthy subjects aged between 25 and 67, the Rayleigh-wave speed was 7.86 ± 0.75 m/s, corresponding to a shear modulus of 72 ± 14 kPa. Our data reveal two unexpected trends: no correlation was found between the wave speed and IOP between 13–18 mmHg, and shear modulus decreases with age (− 0.32 ± 0.17 m/s per decade). We propose that shear stiffness is governed by the interfibrillar matrix, whereas tensile strength is dominated by collagen fibrils. Rayleigh-wave OCE may prove useful for clinical diagnosis, refractive surgeries, and treatment monitoring. Corneal stiffness plays a critical role in shaping the cornea with respect to intraocular pressure and physical interventions. However, it remains difficult to measure the mechanical properties noninvasively. Here, we report the first measurement of shear modulus in human corneas in vivo using optical coherence elastography (OCE) based on surface elastic waves. In a pilot study of 12 healthy subjects aged between 25 and 67, the Rayleigh-wave speed was 7.86 ± 0.75 m/s, corresponding to a shear modulus of 72 ± 14 kPa. Our data reveal two unexpected trends: no correlation was found between the wave speed and IOP between 13-18 mmHg, and shear modulus decreases with age (- 0.32 ± 0.17 m/s per decade). We propose that shear stiffness is governed by the interfibrillar matrix, whereas tensile strength is dominated by collagen fibrils. Rayleigh-wave OCE may prove useful for clinical diagnosis, refractive surgeries, and treatment monitoring. Corneal stiffness plays a critical role in shaping the cornea with respect to intraocular pressure and physical interventions. However, it remains difficult to measure the mechanical properties noninvasively. Here, we report the first measurement of shear modulus in human corneas in vivo using optical coherence elastography (OCE) based on surface elastic waves. In a pilot study of 12 healthy subjects aged between 25 and 67, the Rayleigh-wave speed was 7.86 ± 0.75 m/s, corresponding to a shear modulus of 72 ± 14 kPa. Our data reveal two unexpected trends: no correlation was found between the wave speed and IOP between 13-18 mmHg, and shear modulus decreases with age (- 0.32 ± 0.17 m/s per decade). We propose that shear stiffness is governed by the interfibrillar matrix, whereas tensile strength is dominated by collagen fibrils. Rayleigh-wave OCE may prove useful for clinical diagnosis, refractive surgeries, and treatment monitoring.Corneal stiffness plays a critical role in shaping the cornea with respect to intraocular pressure and physical interventions. However, it remains difficult to measure the mechanical properties noninvasively. Here, we report the first measurement of shear modulus in human corneas in vivo using optical coherence elastography (OCE) based on surface elastic waves. In a pilot study of 12 healthy subjects aged between 25 and 67, the Rayleigh-wave speed was 7.86 ± 0.75 m/s, corresponding to a shear modulus of 72 ± 14 kPa. Our data reveal two unexpected trends: no correlation was found between the wave speed and IOP between 13-18 mmHg, and shear modulus decreases with age (- 0.32 ± 0.17 m/s per decade). We propose that shear stiffness is governed by the interfibrillar matrix, whereas tensile strength is dominated by collagen fibrils. Rayleigh-wave OCE may prove useful for clinical diagnosis, refractive surgeries, and treatment monitoring. |
| ArticleNumber | 17366 |
| Author | Clouser, Fatima Birkenfeld, Judith S. Chen, YiTong Watts, Amy Eltony, Amira M. Ramier, Antoine Yun, Seok-Hyun |
| Author_xml | – sequence: 1 givenname: Antoine surname: Ramier fullname: Ramier, Antoine organization: Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital, Harvard-MIT Division of Health Sciences and Technology – sequence: 2 givenname: Amira M. surname: Eltony fullname: Eltony, Amira M. organization: Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital – sequence: 3 givenname: YiTong surname: Chen fullname: Chen, YiTong organization: Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital, Department of Automation, Tsinghua University – sequence: 4 givenname: Fatima surname: Clouser fullname: Clouser, Fatima organization: Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital – sequence: 5 givenname: Judith S. surname: Birkenfeld fullname: Birkenfeld, Judith S. organization: Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital, Research Laboratory of Electronics, Massachusetts Institute of Technology, Instituto de Optica (IO-CSIC) – sequence: 6 givenname: Amy surname: Watts fullname: Watts, Amy organization: Department of Ophthalmology, Massachusetts Eye and Ear – sequence: 7 givenname: Seok-Hyun surname: Yun fullname: Yun, Seok-Hyun email: syun@mgh.harvard.edu organization: Wellman Center for Photomedicine and Harvard Medical School, Massachusetts General Hospital, Harvard-MIT Division of Health Sciences and Technology |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33060714$$D View this record in MEDLINE/PubMed |
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| Title | In vivo measurement of shear modulus of the human cornea using optical coherence elastography |
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