Association of 2 Lysyl Oxidase Gene Single Nucleotide Polymorphisms with Keratoconus

• Published in: Ophthalmology science (Online) Vol. 3; no. 2; p. 100247
• Main Authors: Niazi, Sana, Moshirfar, Majid, Alizadeh, Fatemeh, Doroodgar, Farideh, Baradaran-Rafii, Alireza, Filutowski, Oliver, Niazi, Feizollah, Ambrósio, Renato
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.06.2023; Elsevier
• Subjects: Cornea; Extracellular matrix proteins; Genes; Keratoconus; Ophthalmology; Cornea; LOX; SNP; Keratoconus; Extracellular matrix proteins; Genes; HWE; KC; ECM; PCR; single nucleotide polymorphism; lysyl oxidase; Hardy–Weinberg equilibrium; extracellular matrix; polymerase chain reaction
• ISSN: 2666-9145; 2666-9145
• DOI: 10.1016/j.xops.2022.100247

Keratoconus (KC) is the most common primary ectatic corneal disease, characterized by progressive thinning of the cornea, affecting its shape and structure and leading to visual loss. Lysyl oxidase is an important component of the extracellular matrix and contributes to the homeostasis of corneal st...