Variation in Optic Nerve and Macular Structure with Age and Race with Spectral-Domain Optical Coherence Tomography
Purpose To evaluate the effects of age and race on optic disc, retinal nerve fiber layer (RNFL), and macular measurements with spectral-domain optical coherence tomography (SD OCT). Design Cross-sectional observational study. Participants Three hundred fifty adult subjects without ocular disease. Me...
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Published in | Ophthalmology (Rochester, Minn.) Vol. 118; no. 12; pp. 2403 - 2408 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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New York, NY
Elsevier Inc
01.12.2011
Elsevier |
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Abstract | Purpose To evaluate the effects of age and race on optic disc, retinal nerve fiber layer (RNFL), and macular measurements with spectral-domain optical coherence tomography (SD OCT). Design Cross-sectional observational study. Participants Three hundred fifty adult subjects without ocular disease. Methods Data from SD OCT imaging of the optic nerve head, peripapillary RNFL, and macula of 632 eyes from 350 subjects without ocular disease were imaged with SD OCT. Multivariate models were used to determine the effect of age and race on quantitative measurements of optic disc, RNFL, and macula. Main Outcome Measures Optic nerve, RNFL, and macular measurements with SD OCT across racial strata and age. Results For optic nerve parameters, participants of European descent had significantly smaller optic disc area than other groups ( P <0.0001), and Indian participants had significantly smaller rim area than other groups ( P <0.0001). Indian and Hispanic participants had thicker global RNFL measurements than other groups ( P <0.0001). Participants of African descent were associated with thinner inner retinal thickness in the macula ( P <0.0001). Age was associated with several parameters, with rim area reducing by 0.005 mm2 /year, RNFL thickness reducing by 0.18 μm/year, and inner retinal thickness reducing by 0.1 μm/year ( P <0.0001 for all age associations). Conclusions Optic nerve, RNFL, and macular measurements with SD OCT all varied across racial groups and with age. These differences are important in defining the range of normal variation in differing populations and should be considered in the use of these instruments in the detection of optic nerve and macular disease across these population groups. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references. |
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AbstractList | To evaluate the effects of age and race on optic disc, retinal nerve fiber layer (RNFL), and macular measurements with spectral-domain optical coherence tomography (SD OCT).
Cross-sectional observational study.
Three hundred fifty adult subjects without ocular disease.
Data from SD OCT imaging of the optic nerve head, peripapillary RNFL, and macula of 632 eyes from 350 subjects without ocular disease were imaged with SD OCT. Multivariate models were used to determine the effect of age and race on quantitative measurements of optic disc, RNFL, and macula.
Optic nerve, RNFL, and macular measurements with SD OCT across racial strata and age.
For optic nerve parameters, participants of European descent had significantly smaller optic disc area than other groups (P<0.0001), and Indian participants had significantly smaller rim area than other groups (P<0.0001). Indian and Hispanic participants had thicker global RNFL measurements than other groups (P<0.0001). Participants of African descent were associated with thinner inner retinal thickness in the macula (P<0.0001). Age was associated with several parameters, with rim area reducing by 0.005 mm(2)/year, RNFL thickness reducing by 0.18 μm/year, and inner retinal thickness reducing by 0.1 μm/year (P<0.0001 for all age associations).
Optic nerve, RNFL, and macular measurements with SD OCT all varied across racial groups and with age. These differences are important in defining the range of normal variation in differing populations and should be considered in the use of these instruments in the detection of optic nerve and macular disease across these population groups.
Proprietary or commercial disclosure may be found after the references. Purpose To evaluate the effects of age and race on optic disc, retinal nerve fiber layer (RNFL), and macular measurements with spectral-domain optical coherence tomography (SD OCT). Design Cross-sectional observational study. Participants Three hundred fifty adult subjects without ocular disease. Methods Data from SD OCT imaging of the optic nerve head, peripapillary RNFL, and macula of 632 eyes from 350 subjects without ocular disease were imaged with SD OCT. Multivariate models were used to determine the effect of age and race on quantitative measurements of optic disc, RNFL, and macula. Main Outcome Measures Optic nerve, RNFL, and macular measurements with SD OCT across racial strata and age. Results For optic nerve parameters, participants of European descent had significantly smaller optic disc area than other groups ( P <0.0001), and Indian participants had significantly smaller rim area than other groups ( P <0.0001). Indian and Hispanic participants had thicker global RNFL measurements than other groups ( P <0.0001). Participants of African descent were associated with thinner inner retinal thickness in the macula ( P <0.0001). Age was associated with several parameters, with rim area reducing by 0.005 mm2 /year, RNFL thickness reducing by 0.18 μm/year, and inner retinal thickness reducing by 0.1 μm/year ( P <0.0001 for all age associations). Conclusions Optic nerve, RNFL, and macular measurements with SD OCT all varied across racial groups and with age. These differences are important in defining the range of normal variation in differing populations and should be considered in the use of these instruments in the detection of optic nerve and macular disease across these population groups. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references. To evaluate the effects of age and race on optic disc, retinal nerve fiber layer (RNFL), and macular measurements with spectral-domain optical coherence tomography (SD OCT). Cross-sectional observational study. Three hundred fifty adult subjects without ocular disease. Data from SD OCT imaging of the optic nerve head, peripapillary RNFL, and macula of 632 eyes from 350 subjects without ocular disease were imaged with SD OCT. Multivariate models were used to determine the effect of age and race on quantitative measurements of optic disc, RNFL, and macula. Optic nerve, RNFL, and macular measurements with SD OCT across racial strata and age. For optic nerve parameters, participants of European descent had significantly smaller optic disc area than other groups ( P<0.0001), and Indian participants had significantly smaller rim area than other groups ( P<0.0001). Indian and Hispanic participants had thicker global RNFL measurements than other groups ( P<0.0001). Participants of African descent were associated with thinner inner retinal thickness in the macula ( P<0.0001). Age was associated with several parameters, with rim area reducing by 0.005 mm 2/year, RNFL thickness reducing by 0.18 μm/year, and inner retinal thickness reducing by 0.1 μm/year ( P<0.0001 for all age associations). Optic nerve, RNFL, and macular measurements with SD OCT all varied across racial groups and with age. These differences are important in defining the range of normal variation in differing populations and should be considered in the use of these instruments in the detection of optic nerve and macular disease across these population groups. Proprietary or commercial disclosure may be found after the references. PURPOSETo evaluate the effects of age and race on optic disc, retinal nerve fiber layer (RNFL), and macular measurements with spectral-domain optical coherence tomography (SD OCT).DESIGNCross-sectional observational study.PARTICIPANTSThree hundred fifty adult subjects without ocular disease.METHODSData from SD OCT imaging of the optic nerve head, peripapillary RNFL, and macula of 632 eyes from 350 subjects without ocular disease were imaged with SD OCT. Multivariate models were used to determine the effect of age and race on quantitative measurements of optic disc, RNFL, and macula.MAIN OUTCOME MEASURESOptic nerve, RNFL, and macular measurements with SD OCT across racial strata and age.RESULTSFor optic nerve parameters, participants of European descent had significantly smaller optic disc area than other groups (P<0.0001), and Indian participants had significantly smaller rim area than other groups (P<0.0001). Indian and Hispanic participants had thicker global RNFL measurements than other groups (P<0.0001). Participants of African descent were associated with thinner inner retinal thickness in the macula (P<0.0001). Age was associated with several parameters, with rim area reducing by 0.005 mm(2)/year, RNFL thickness reducing by 0.18 μm/year, and inner retinal thickness reducing by 0.1 μm/year (P<0.0001 for all age associations).CONCLUSIONSOptic nerve, RNFL, and macular measurements with SD OCT all varied across racial groups and with age. These differences are important in defining the range of normal variation in differing populations and should be considered in the use of these instruments in the detection of optic nerve and macular disease across these population groups.FINANCIAL DISCLOSURE(S)Proprietary or commercial disclosure may be found after the references. |
Author | Araie, Makoto, MD, PhD Girkin, Christopher A., MD, MSPH Varma, Rohit, MD Sekhar, G. Chandra, MD McGwin, Gerald, MS, PhD Garway-Heath, David F., MD Tomita, Goji, MD Sinai, Micheal J., PhD Wollstein, Gadi, MD Liebmann, Jeffery, MD Maeda, Naoyuki, MD Fingeret, Murrey, OD Greenfield, David, MD |
Author_xml | – sequence: 1 fullname: Girkin, Christopher A., MD, MSPH – sequence: 2 fullname: McGwin, Gerald, MS, PhD – sequence: 3 fullname: Sinai, Micheal J., PhD – sequence: 4 fullname: Sekhar, G. Chandra, MD – sequence: 5 fullname: Fingeret, Murrey, OD – sequence: 6 fullname: Wollstein, Gadi, MD – sequence: 7 fullname: Varma, Rohit, MD – sequence: 8 fullname: Greenfield, David, MD – sequence: 9 fullname: Liebmann, Jeffery, MD – sequence: 10 fullname: Araie, Makoto, MD, PhD – sequence: 11 fullname: Tomita, Goji, MD – sequence: 12 fullname: Maeda, Naoyuki, MD – sequence: 13 fullname: Garway-Heath, David F., MD |
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Keywords | Macula Optic nerve Optical coherence tomography Race Variations Ophthalmology Structure Age |
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Snippet | Purpose To evaluate the effects of age and race on optic disc, retinal nerve fiber layer (RNFL), and macular measurements with spectral-domain optical... To evaluate the effects of age and race on optic disc, retinal nerve fiber layer (RNFL), and macular measurements with spectral-domain optical coherence... PURPOSETo evaluate the effects of age and race on optic disc, retinal nerve fiber layer (RNFL), and macular measurements with spectral-domain optical coherence... |
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SubjectTerms | Adult Aged Aged, 80 and over Aging - physiology Biological and medical sciences Body Weights and Measures Continental Population Groups Cross-Sectional Studies Ethnic Groups Female Humans Intraocular Pressure - physiology Macula Lutea - anatomy & histology Male Medical sciences Middle Aged Miscellaneous Nerve Fibers Ophthalmology Optic Disk - anatomy & histology Prospective Studies Retinal Ganglion Cells - cytology Tomography, Optical Coherence Visual Acuity - physiology Young Adult |
Title | Variation in Optic Nerve and Macular Structure with Age and Race with Spectral-Domain Optical Coherence Tomography |
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