The effect of insulin-induced hypoglycemia on inflammatory markers: A systematic review
•Acute hypoglycaemia induces a pro-inflammatory state.•Elevation of inflammatory markers occurs in both type-1 and non-diabetic subjects.•Activation of the sympathetic nervous system is a likely mediator of these effects. The effects of acute hypoglycemia on markers of inflammation have been investi...
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| Published in | Brain, behavior, and immunity Vol. 73; pp. 41 - 50 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Inc
01.10.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0889-1591 1090-2139 1090-2139 |
| DOI | 10.1016/j.bbi.2018.05.003 |
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| Abstract | •Acute hypoglycaemia induces a pro-inflammatory state.•Elevation of inflammatory markers occurs in both type-1 and non-diabetic subjects.•Activation of the sympathetic nervous system is a likely mediator of these effects.
The effects of acute hypoglycemia on markers of inflammation have been investigated, but the results have been heterogeneous.
We aimed to perform a systematic review about the acute effects of insulin-induced hypoglycemia on inflammatory markers in patients with diabetes as well as non-diabetic subjects.
A systematic search of the literature using the electronic databases MEDLINE and SCOPUS was conducted through September 2017. Search terms included: “hypoglycemia”,“ insulin”, “cytokines”, and “inflammation”. We included original studies assessing peripheral inflammatory markers during insulin-induced hypoglycemia in humans.
Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. Acute hypoglycemia increases total leukocyte number and several pro-inflammatory markers. Elevation in pro-inflammatory markers in response to insulin-induced acute hypoglycemia appears to be of similar magnitude in non-diabetic subjects and in type-1 diabetic patients with intact awareness of hypoglycemia. Adrenaline rises in response to acute hypoglycemia correlates with the increase of pro-inflammatory markers.
Acute hypoglycemia induces a pro-inflammatory state in both type-1 diabetic and non-diabetic subjects with no apparent significant difference between these two populations. Activation of the sympathetic nervous system is a likely mediator of these effects. |
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| AbstractList | The effects of acute hypoglycemia on markers of inflammation have been investigated, but the results have been heterogeneous.
We aimed to perform a systematic review about the acute effects of insulin-induced hypoglycemia on inflammatory markers in patients with diabetes as well as non-diabetic subjects.
A systematic search of the literature using the electronic databases MEDLINE and SCOPUS was conducted through September 2017. Search terms included: "hypoglycemia"," insulin", "cytokines", and "inflammation". We included original studies assessing peripheral inflammatory markers during insulin-induced hypoglycemia in humans.
Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. Acute hypoglycemia increases total leukocyte number and several pro-inflammatory markers. Elevation in pro-inflammatory markers in response to insulin-induced acute hypoglycemia appears to be of similar magnitude in non-diabetic subjects and in type-1 diabetic patients with intact awareness of hypoglycemia. Adrenaline rises in response to acute hypoglycemia correlates with the increase of pro-inflammatory markers.
Acute hypoglycemia induces a pro-inflammatory state in both type-1 diabetic and non-diabetic subjects with no apparent significant difference between these two populations. Activation of the sympathetic nervous system is a likely mediator of these effects. •Acute hypoglycaemia induces a pro-inflammatory state.•Elevation of inflammatory markers occurs in both type-1 and non-diabetic subjects.•Activation of the sympathetic nervous system is a likely mediator of these effects. The effects of acute hypoglycemia on markers of inflammation have been investigated, but the results have been heterogeneous. We aimed to perform a systematic review about the acute effects of insulin-induced hypoglycemia on inflammatory markers in patients with diabetes as well as non-diabetic subjects. A systematic search of the literature using the electronic databases MEDLINE and SCOPUS was conducted through September 2017. Search terms included: “hypoglycemia”,“ insulin”, “cytokines”, and “inflammation”. We included original studies assessing peripheral inflammatory markers during insulin-induced hypoglycemia in humans. Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. Acute hypoglycemia increases total leukocyte number and several pro-inflammatory markers. Elevation in pro-inflammatory markers in response to insulin-induced acute hypoglycemia appears to be of similar magnitude in non-diabetic subjects and in type-1 diabetic patients with intact awareness of hypoglycemia. Adrenaline rises in response to acute hypoglycemia correlates with the increase of pro-inflammatory markers. Acute hypoglycemia induces a pro-inflammatory state in both type-1 diabetic and non-diabetic subjects with no apparent significant difference between these two populations. Activation of the sympathetic nervous system is a likely mediator of these effects. The effects of acute hypoglycemia on markers of inflammation have been investigated, but the results have been heterogeneous.INTRODUCTIONThe effects of acute hypoglycemia on markers of inflammation have been investigated, but the results have been heterogeneous.We aimed to perform a systematic review about the acute effects of insulin-induced hypoglycemia on inflammatory markers in patients with diabetes as well as non-diabetic subjects.OBJECTIVEWe aimed to perform a systematic review about the acute effects of insulin-induced hypoglycemia on inflammatory markers in patients with diabetes as well as non-diabetic subjects.A systematic search of the literature using the electronic databases MEDLINE and SCOPUS was conducted through September 2017. Search terms included: "hypoglycemia"," insulin", "cytokines", and "inflammation". We included original studies assessing peripheral inflammatory markers during insulin-induced hypoglycemia in humans.METHODSA systematic search of the literature using the electronic databases MEDLINE and SCOPUS was conducted through September 2017. Search terms included: "hypoglycemia"," insulin", "cytokines", and "inflammation". We included original studies assessing peripheral inflammatory markers during insulin-induced hypoglycemia in humans.Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. Acute hypoglycemia increases total leukocyte number and several pro-inflammatory markers. Elevation in pro-inflammatory markers in response to insulin-induced acute hypoglycemia appears to be of similar magnitude in non-diabetic subjects and in type-1 diabetic patients with intact awareness of hypoglycemia. Adrenaline rises in response to acute hypoglycemia correlates with the increase of pro-inflammatory markers.RESULTSTwo hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. Acute hypoglycemia increases total leukocyte number and several pro-inflammatory markers. Elevation in pro-inflammatory markers in response to insulin-induced acute hypoglycemia appears to be of similar magnitude in non-diabetic subjects and in type-1 diabetic patients with intact awareness of hypoglycemia. Adrenaline rises in response to acute hypoglycemia correlates with the increase of pro-inflammatory markers.Acute hypoglycemia induces a pro-inflammatory state in both type-1 diabetic and non-diabetic subjects with no apparent significant difference between these two populations. Activation of the sympathetic nervous system is a likely mediator of these effects.CONCLUSIONAcute hypoglycemia induces a pro-inflammatory state in both type-1 diabetic and non-diabetic subjects with no apparent significant difference between these two populations. Activation of the sympathetic nervous system is a likely mediator of these effects. |
| Author | Teixeira, Antonio L. Barbosa, Izabela G. Dantzer, Robert Drummond, Juliana B. |
| Author_xml | – sequence: 1 givenname: Juliana B. surname: Drummond fullname: Drummond, Juliana B. email: juliana.drummond@ebserh.gov.br organization: Servico de Endocrinologia do Hospital das Clinicas da Universidade Federal de Minas Gerais, Brazil – sequence: 2 givenname: Izabela G. surname: Barbosa fullname: Barbosa, Izabela G. organization: Laboratorio Interdisciplinar de Investigacao Medica, Faculdade de Medicina, UFMG, Belo Horizonte, Brazil – sequence: 3 givenname: Robert surname: Dantzer fullname: Dantzer, Robert organization: Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, USA – sequence: 4 givenname: Antonio L. surname: Teixeira fullname: Teixeira, Antonio L. organization: Laboratorio Interdisciplinar de Investigacao Medica, Faculdade de Medicina, UFMG, Belo Horizonte, Brazil |
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| CitedBy_id | crossref_primary_10_1111_dme_15456 crossref_primary_10_1016_j_autneu_2022_102983 crossref_primary_10_1111_odi_12977 crossref_primary_10_1007_s11102_020_01076_6 crossref_primary_10_1016_j_ibneur_2021_08_002 crossref_primary_10_1177_14791641241278506 crossref_primary_10_3389_fendo_2022_887976 crossref_primary_10_3390_ijms22157783 crossref_primary_10_1016_j_jneuroim_2020_577446 crossref_primary_10_3390_nu14030611 |
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| Keywords | Hypoglycemia Insulin Inflammation |
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| Snippet | •Acute hypoglycaemia induces a pro-inflammatory state.•Elevation of inflammatory markers occurs in both type-1 and non-diabetic subjects.•Activation of the... The effects of acute hypoglycemia on markers of inflammation have been investigated, but the results have been heterogeneous. We aimed to perform a systematic... The effects of acute hypoglycemia on markers of inflammation have been investigated, but the results have been heterogeneous.INTRODUCTIONThe effects of acute... |
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| SubjectTerms | Biomarkers - blood Biomarkers - metabolism Blood Glucose - metabolism Diabetes Mellitus - metabolism Diabetes Mellitus, Type 1 - metabolism Female Humans Hypoglycemia Hypoglycemia - metabolism Inflammation Inflammation - metabolism Insulin Insulin - metabolism Insulin - physiology Male Sympathetic Nervous System - metabolism |
| Title | The effect of insulin-induced hypoglycemia on inflammatory markers: A systematic review |
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