YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

• Published in: Genes & development Vol. 23; no. 23; pp. 2729 - 2741
• Main Authors: Fernandez-L, Africa, Northcott, Paul A., Dalton, James, Fraga, Charles, Ellison, David, Angers, Stephane, Taylor, Michael D., Kenney, Anna Marie
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.12.2009
• Subjects: Animals; Cell Proliferation; Cells, Cultured; Cerebellar Neoplasms - metabolism; Cerebellar Neoplasms - pathology; Hedgehog Proteins - metabolism; Humans; Insulin Receptor Substrate Proteins - metabolism; Medulloblastoma - metabolism; Medulloblastoma - pathology; Mice; Neurons - cytology; Neurons - metabolism; Protein Transport; Research Paper; Signal Transduction; Transcription Factors - metabolism; Up-Regulation

Medulloblastoma is the most common solid malignancy of childhood, with treatment side effects reducing survivors’ quality of life and lethality being associated with tumor recurrence. Activation of the Sonic hedgehog (Shh) signaling pathway is implicated in human medulloblastomas. Cerebellar granule...