Substitution of dietary monounsaturated fatty acids from olive oil for saturated fatty acids from lard increases low-density lipoprotein apolipoprotein B-100 fractional catabolic rate in subjects with dyslipidemia associated with insulin resistance: a randomized controlled trial

• Published in: The American journal of clinical nutrition Vol. 119; no. 5; pp. 1270 - 1279
• Main Authors: Desjardins, Louis-Charles, Brière, Francis, Tremblay, André J, Rancourt-Bouchard, Maryka, Drouin-Chartier, Jean-Philippe, Corbeil, Jacques, Lemelin, Valéry, Charest, Amélie, Schaefer, Ernst J, Lamarche, Benoît, Couture, Patrick
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2024; American Society for Clinical Nutrition, Inc; American Society for Nutrition
• Subjects: Adult; Apolipoprotein B; Apolipoprotein B-100 - blood; Apolipoproteins; Cardiovascular diseases; Cholesterol; Clinical trials; Cross-Over Studies; Density; Diet; Dietary Fats; Double-Blind Method; Dyslipidemia; Dyslipidemias - diet therapy; Fatty acids; Fatty Acids - blood; Fatty Acids, Monounsaturated; Female; High density lipoprotein; Humans; Insulin; Insulin Resistance; Kinetics; Lipid metabolism; lipidomics; lipoprotein metabolism; Lipoproteins; Low density lipoprotein; Male; Metabolic disorders; Middle Aged; monounsaturated fatty acids; Olive Oil; Original; saturated fatty acids; Substitutes; Triglycerides; LPE; PR; DG; PS; LCAT; LPL; TRL; LC-MS/MS; SPT; lipoprotein metabolism; RLP; saturated fatty acids; SM; insulin resistance; LDLR; sdLDL; apo; T2D; INAF; IR; monounsaturated fatty acids; CIU; CVD; Cer; NMR; PC; TG; FCR; PE; lipidomics; LPC

The substitution of monounsaturated acids (MUFAs) for saturated fatty acids (SFAs) is recommended for cardiovascular disease prevention but its impact on lipoprotein metabolism in subjects with dyslipidemia associated with insulin resistance (IR) remains largely unknown. This study aimed to evaluate...