Pathogenesis and novel therapeutics of regulatory T cell subsets and interleukin-2 therapy in systemic lupus erythematosus

• Published in: Frontiers in immunology Vol. 14; p. 1230264
• Main Authors: Tsai, Yi-Giien, Liao, Pei-Fen, Hsiao, Kai-Hung, Wu, Hung-Ming, Lin, Ching-Yuang, Yang, Kuender D.
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 12.09.2023
• Subjects: B regulatory cells; Immunology; interleukin-2; lupus nephritis; regulatory T cells; systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a heterogeneous multisystem inflammatory disease with wide variability in clinical manifestations. Natural arising CD4+ regulatory T cells (Tregs) play a critical role in maintaining peripheral tolerance by suppressing inflammation and preventing autoimmune resp...