The role of prelimbic cortex in instrumental conditioning

• Published in: Behavioural brain research Vol. 146; no. 1; pp. 145 - 157
• Main Authors: Corbit, Laura H, Balleine, Bernard W
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.11.2003
• Subjects: Animals; Association Learning - drug effects; Association Learning - physiology; Behavior, Animal; Conditioning, Classical; Conditioning, Operant - physiology; Contingency; Devaluation; Excitatory Amino Acid Agonists - toxicity; Extinction, Psychological - physiology; Food Deprivation; Incentive; Instrumental conditioning; Limbic System - anatomy & histology; Limbic System - drug effects; Limbic System - physiology; Male; Memory - physiology; N-Methylaspartate - toxicity; Pavlovian conditioning; Pavlovian-instrumental transfer; Prefrontal cortex; Prefrontal Cortex - anatomy & histology; Prefrontal Cortex - drug effects; Prefrontal Cortex - physiology; Prelimbic cortex; Rat; Rats; Rats, Long-Evans; Reinforcement (Psychology); Reinforcement Schedule; Reward; Transfer (Psychology) - physiology; Incentive; Pavlovian-instrumental transfer; Pavlovian conditioning; Rat; Prelimbic cortex; Instrumental conditioning; Prefrontal cortex; Devaluation; Reward; Contingency

Numerous studies have implicated human and primate prefrontal cortex in the ability to hold and manipulate goal or outcome-related information in working memory to guide the performance of forthcoming actions. Here we report that cell-body lesions of prelimbic cortex impair the ability of rats to se...