Sclerosing Polycystic Adenoma: Conclusive Clinical and Molecular Evidence of Its Neoplastic Nature

• Published in: Head & neck pathology (Totowa, N.J.) Vol. 16; no. 2; pp. 416 - 426
• Main Authors: Hernandez-Prera, Juan C., Saeed-Vafa, Daryoush, Heidarian, Amin, Gewandter, Kathleen, Otto, Kristen, Wenig, Bruce M.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2022
• Subjects: Adenoma - genetics; Adenoma - pathology; Adolescent; Adult; Aged; Child; Class I Phosphatidylinositol 3-Kinases - genetics; Cysts - pathology; Dentistry; Female; Hamartoma Syndrome, Multiple; Humans; Hyperplasia; Male; Medicine; Medicine & Public Health; Middle Aged; Oral and Maxillofacial Surgery; Original Paper; Otorhinolaryngology; Pathology; Phosphatidylinositol 3-Kinases - genetics; Young Adult; Cowden syndrome; Sclerosing polycystic adenosis; PTEN; PI3K pathway; Sclerosing polycystic adenoma

Sclerosing polycystic adenosis, initially considered a non-neoplastic salivary gland lesion and classified as such in the 2017 WHO Classification of Head and Neck Tumors, has been the subject of controversy regarding its possible neoplastic nature. The reporting of recurrent PI3K pathway alteration...