The Impact of Baseline Pain Intensity on the Analgesic Efficacy of Ibuprofen/Caffeine in Patients with Acute Postoperative Dental Pain: Post Hoc Subgroup Analysis of a Randomised Controlled Trial

• Published in: Advances in therapy Vol. 37; no. 6; pp. 2976 - 2987
• Main Authors: Förderreuther, Stefanie, Lampert, Anette, Hitier, Simon, Lange, Robert, Weiser, Thomas
• Format: Journal Article
• Language: English
• Published: Cheshire Springer Healthcare 01.06.2020
• Subjects: Acute Pain - drug therapy; Adolescent; Adult; Analgesics - administration & dosage; Analgesics - therapeutic use; Caffeine - administration & dosage; Caffeine - therapeutic use; Cardiology; Dose-Response Relationship, Drug; Double-Blind Method; Endocrinology; Female; Humans; Ibuprofen - administration & dosage; Ibuprofen - therapeutic use; Internal Medicine; Male; Medicine; Medicine & Public Health; NCT; NCT01929031; Oncology; Original Research; Pain Management - methods; Pain, Postoperative - drug therapy; Pharmacology/Toxicology; Rheumatology; Tooth, Impacted - surgery; Young Adult; Analgesia; Postoperative pain; Dental pain; Fixed-dose combination; Ibuprofen; Caffeine

Introduction A fixed dose combination (FDC) of ibuprofen 400 mg and caffeine 100 mg has been shown to be more effective than ibuprofen 400 mg alone for the treatment of acute postoperative dental pain in a phase III randomised controlled trial. A post hoc subgroup analysis of the primary data from a...