Preliminary insights into the impact of primary radiochemotherapy on the salivary microbiome in head and neck squamous cell carcinoma

• Published in: Scientific reports Vol. 10; no. 1; p. 16582
• Main Authors: Kumpitsch, Christina, Moissl-Eichinger, Christine, Pock, Jakob, Thurnher, Dietmar, Wolf, Axel
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.10.2020
• Subjects: 631/326/2565/2134; 631/67/1059/485; 631/67/1059/99; 692/4028/67/1536; Adult; Aged; Candida - genetics; Candida - isolation & purification; Chemoradiotherapy; Female; Head and Neck Neoplasms - microbiology; Head and Neck Neoplasms - therapy; Healthy Volunteers; High-Throughput Nucleotide Sequencing; Humanities and Social Sciences; Humans; Male; Microbiota - drug effects; Microbiota - genetics; Microbiota - radiation effects; Middle Aged; multidisciplinary; RNA, Ribosomal, 16S - genetics; Saliva - microbiology; Science; Science (multidisciplinary); Squamous Cell Carcinoma of Head and Neck - microbiology; Squamous Cell Carcinoma of Head and Neck - therapy

Squamous cell carcinoma is the most common type of throat cancer. Treatment options comprise surgery, radiotherapy, and/or chemo(immuno)therapy. The salivary microbiome is shaped by the disease, and likely by the treatment, resulting in side effects caused by chemoradiation that severely impair pati...