Genes and hormones of the hypothalamic–pituitary–adrenal axis in post-traumatic stress disorder. What is their role in symptom expression and treatment response?

• Published in: Journal of Neural Transmission Vol. 128; no. 9; pp. 1279 - 1286
• Main Authors: Fischer, Susanne, Schumacher, Tabea, Knaevelsrud, Christine, Ehlert, Ulrike, Schumacher, Sarah
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.09.2021
• Subjects: Cognitive Behavioral Therapy; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Medicine; Medicine & Public Health; Neurology; Neurosciences; Pituitary-Adrenal System; Psychiatry; Psychiatry and Preclinical Psychiatric Studies - Review; Psychiatry and Preclinical Psychiatric Studies - Review Article; Stress Disorders, Post-Traumatic - genetics; Stress Disorders, Post-Traumatic - therapy; Psychotherapy; Cortisol; Cognitive behavioural therapy; Methylation; Post-traumatic stress disorder

Background Less than half of all individuals with post-traumatic stress disorder (PTSD) remit spontaneously and a large proportion of those seeking treatment do not respond sufficiently. This suggests that there may be subgroups of individuals who are in need of augmentative or alternative treatment...