Metabolomics study on the therapeutic effect of traditional Chinese medicine Xue-Fu-Zhu-Yu decoction in coronary heart disease based on LC-Q-TOF/MS and GC-MS analysis

• Published in: Drug metabolism and pharmacokinetics Vol. 34; no. 5; pp. 340 - 349
• Main Authors: Yi, Min, Li, Qiuxia, Zhao, Yuhang, Nie, Shanshan, Wu, Ning, Wang, Dongsheng
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2019
• Subjects: Blood-stasis syndrome; CHD; Chromatography, Liquid; Coronary Disease - blood; Coronary Disease - drug therapy; Coronary Disease - metabolism; Drugs, Chinese Herbal - analysis; Drugs, Chinese Herbal - metabolism; Drugs, Chinese Herbal - therapeutic use; Female; Humans; Male; Mass Spectrometry; Medicine, Chinese Traditional; Metabolomics; Multivariate Analysis; Pathway; Xue-Fu-Zhu-Yu capsule; Metabolomics; LC-Q-TOF/MS; Pathway; Blood-stasis syndrome; OPLS-DA; Xue-Fu-Zhu-Yu capsule; PLS-DA; CHD; XFZYD; PCA

The present study aims is to investigate the metabolic mechanism of Xue-Fu-Zhu-Yu decoction (XFZYD) in the treatment of blood-stasis syndrome in Coronary Heart Disease (CHD). To that end, 30 CHD patients with Blood-Stasis Syndrome (BSS) and 20 healthy subjects were enrolled. LC-Q-TOF/MS analysis det...