Structure-based discovery of small molecule inhibitors of FKBP51-Hsp90 protein-protein interaction

• Published in: European journal of medicinal chemistry Vol. 270; p. 116356
• Main Authors: Wang, Lisha, Kumar, Rajnish, Winblad, Bengt, Pavlov, Pavel F.
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 15.04.2024
• Subjects: FKBP51; FKBP52; Hsp90; Protein-protein interaction inhibitors; TPR co-chaperones; Hsp90; Protein-protein interaction inhibitors; TPR co-chaperones; FKBP52; FKBP51

The heat shock protein 90 kDa (Hsp90) molecular chaperone machinery is responsible for the folding and activation of hundreds of important clients such as kinases, steroid hormone receptors, transcription factors, etc. This process is dynamically regulated in an ATP-dependent manner by Hsp90 co-chap...