Complement Factor C5a Is Increased in Blood of Patients with Abdominal Aortic Aneurysm and Has Prognostic Potential for Aneurysm Growth

In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to...

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Published inJournal of cardiovascular translational research Vol. 14; no. 4; pp. 761 - 769
Main Authors Zagrapan, Branislav, Eilenberg, Wolf, Scheuba, Andreas, Klopf, Johannes, Brandau, Annika, Story, Julia, Dosch, Katharina, Hayden, Hubert, Domenig, Christoph M., Fuchs, Lukas, Schernthaner, Rüdiger, Ristl, Robin, Huk, Ihor, Neumayer, Christoph, Brostjan, Christine
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2021
Subjects
Aged
Aged, 80 and over
Aortic Aneurysm, Abdominal - blood
Aortic Aneurysm, Abdominal - diagnostic imaging
Aortography
Biomarkers - blood
Biomedical Engineering and Bioengineering
Biomedicine
Cardiology
Case-Control Studies
Complement C5a - analysis
Computed Tomography Angiography
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
Human Genetics
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Original
Original Article
Predictive Value of Tests
Prognosis
Time Factors
Up-Regulation
C3a
Prognosis
Diagnosis
Leukotriene B4
C5a
Abdominal aortic aneurysm
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Abstract In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to healthy controls—median 84.5 ng/ml (IQR = 37.5 ng/ml) vs. 67.7 ng/ml (IQR = 26.2 ng/ml), p  = 0.007—but was not elevated in patients with athero-occlusive disease. Serum C5a levels correlated significantly with the increase in maximum AAA diameter over the following 6 months ( r  = 0.319, p  = 0.021). The median growth in the lowest quartile of C5a (< 70 ng/ml) was 50% less compared to the highest C5a quartile (> 101 ng/ml): 1.0 mm/6 months (IQR = 0.8 mm) vs. 2.0 mm/6 months (IQR = 1.5 mm), p  = 0.014. A log-linear mixed model predicted AAA expansion based on current diameter and C5a level. To our knowledge, this is the first study linking complement activation, in particular C5a serum level, with AAA progression. Graphical Abstract
AbstractList Abstract In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to healthy controls—median 84.5 ng/ml (IQR = 37.5 ng/ml) vs. 67.7 ng/ml (IQR = 26.2 ng/ml), p  = 0.007—but was not elevated in patients with athero-occlusive disease. Serum C5a levels correlated significantly with the increase in maximum AAA diameter over the following 6 months ( r  = 0.319, p  = 0.021). The median growth in the lowest quartile of C5a (< 70 ng/ml) was 50% less compared to the highest C5a quartile (> 101 ng/ml): 1.0 mm/6 months (IQR = 0.8 mm) vs. 2.0 mm/6 months (IQR = 1.5 mm), p  = 0.014. A log-linear mixed model predicted AAA expansion based on current diameter and C5a level. To our knowledge, this is the first study linking complement activation, in particular C5a serum level, with AAA progression. Graphical Abstract
In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to healthy controls—median 84.5 ng/ml (IQR = 37.5 ng/ml) vs. 67.7 ng/ml (IQR = 26.2 ng/ml), p  = 0.007—but was not elevated in patients with athero-occlusive disease. Serum C5a levels correlated significantly with the increase in maximum AAA diameter over the following 6 months ( r  = 0.319, p  = 0.021). The median growth in the lowest quartile of C5a (< 70 ng/ml) was 50% less compared to the highest C5a quartile (> 101 ng/ml): 1.0 mm/6 months (IQR = 0.8 mm) vs. 2.0 mm/6 months (IQR = 1.5 mm), p  = 0.014. A log-linear mixed model predicted AAA expansion based on current diameter and C5a level. To our knowledge, this is the first study linking complement activation, in particular C5a serum level, with AAA progression.
In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to healthy controls—median 84.5 ng/ml (IQR = 37.5 ng/ml) vs. 67.7 ng/ml (IQR = 26.2 ng/ml), p  = 0.007—but was not elevated in patients with athero-occlusive disease. Serum C5a levels correlated significantly with the increase in maximum AAA diameter over the following 6 months ( r  = 0.319, p  = 0.021). The median growth in the lowest quartile of C5a (< 70 ng/ml) was 50% less compared to the highest C5a quartile (> 101 ng/ml): 1.0 mm/6 months (IQR = 0.8 mm) vs. 2.0 mm/6 months (IQR = 1.5 mm), p  = 0.014. A log-linear mixed model predicted AAA expansion based on current diameter and C5a level. To our knowledge, this is the first study linking complement activation, in particular C5a serum level, with AAA progression. Graphical Abstract
In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to healthy controls-median 84.5 ng/ml (IQR = 37.5 ng/ml) vs. 67.7 ng/ml (IQR = 26.2 ng/ml), p = 0.007-but was not elevated in patients with athero-occlusive disease. Serum C5a levels correlated significantly with the increase in maximum AAA diameter over the following 6 months (r = 0.319, p = 0.021). The median growth in the lowest quartile of C5a (< 70 ng/ml) was 50% less compared to the highest C5a quartile (> 101 ng/ml): 1.0 mm/6 months (IQR = 0.8 mm) vs. 2.0 mm/6 months (IQR = 1.5 mm), p = 0.014. A log-linear mixed model predicted AAA expansion based on current diameter and C5a level. To our knowledge, this is the first study linking complement activation, in particular C5a serum level, with AAA progression.
Author Story, Julia
Fuchs, Lukas
Brandau, Annika
Huk, Ihor
Scheuba, Andreas
Eilenberg, Wolf
Dosch, Katharina
Zagrapan, Branislav
Schernthaner, Rüdiger
Brostjan, Christine
Hayden, Hubert
Ristl, Robin
Neumayer, Christoph
Domenig, Christoph M.
Klopf, Johannes
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  surname: Brostjan
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  organization: Department of Surgery: Division of Vascular Surgery and Surgical Research Laboratories, Medical University of Vienna, Vienna General Hospital
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Issue 4
Keywords C3a
Prognosis
Diagnosis
Leukotriene B4
C5a
Abdominal aortic aneurysm
Language English
License 2020. The Author(s).
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    fullname: V Fontaine
– volume: 34
  start-page: 291
  issue: 2
  year: 2001
  ident: 10086_CR31
  publication-title: Journal of Vascular Surgery
  doi: 10.1067/mva.2001.114813
  contributor:
    fullname: DA Vorp
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Snippet In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic...
Abstract In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal...
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Publisher
StartPage 761
SubjectTerms Aged
Aged, 80 and over
Aortic Aneurysm, Abdominal - blood
Aortic Aneurysm, Abdominal - diagnostic imaging
Aortography
Biomarkers - blood
Biomedical Engineering and Bioengineering
Biomedicine
Cardiology
Case-Control Studies
Complement C5a - analysis
Computed Tomography Angiography
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
Human Genetics
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Original
Original Article
Predictive Value of Tests
Prognosis
Time Factors
Up-Regulation
Title Complement Factor C5a Is Increased in Blood of Patients with Abdominal Aortic Aneurysm and Has Prognostic Potential for Aneurysm Growth
URI https://link.springer.com/article/10.1007/s12265-020-10086-5
https://www.ncbi.nlm.nih.gov/pubmed/33332020
https://search.proquest.com/docview/2470900388
https://pubmed.ncbi.nlm.nih.gov/PMC8397625
Volume 14
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