Moderate-dose Regular Lifelong Alcohol Intake Changes the Intestinal Flora, Protects against Aging, and Keeps Spatial Memory in the Senescence-accelerated Mouse Prone 8 (SAMP8) Model

• Published in: Journal of pharmacy & pharmaceutical sciences Vol. 19; no. 4; pp. 430 - 447
• Main Authors: Shimizu, Chikako, Oki, Yasuhiro, Mitani, Yutaka, Tsuchiya, Youichi, Nabeshima, Toshitaka
• Format: Journal Article
• Language: English
• Published: Canada Frontiers Media S.A 03.11.2016
• Subjects: Aging - drug effects; Animals; Ethanol - administration & dosage; Ethanol - pharmacology; Gastrointestinal Microbiome - drug effects; Male; Mice; Models, Animal; Protective Agents - administration & dosage; Protective Agents - pharmacology; Spatial Memory - drug effects

Heavy and long-term alcohol consumption increase the risk of alcohol-related diseases. Epidemiological studies show moderate drinking reduces the risk of mortality, cardiovascular diseases, and brain infarction in the J-shaped or U-shaped curve effect. However, why moderate drinkers may be healthy a...