Are Colonoscopy and Bowel Ultrasound Useful for Assessing Response to Short-Term Therapy and Predicting Disease Outcome of Moderate-to-Severe Forms of Ulcerative Colitis?: A Prospective Study

• Published in: The American journal of gastroenterology Vol. 105; no. 5; pp. 1150 - 1157
• Main Authors: Parente, Fabrizio, Molteni, Mirko, Marino, Barbara, Colli, Agostino, Ardizzone, Sandro, Greco, Salvatore, Sampietro, Gianluca, Foschi, Diego, Gallus, Silvano
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.05.2010; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Adolescent; Adrenal Cortex Hormones - therapeutic use; Adult; Biological and medical sciences; Cohort Studies; Colitis, Ulcerative - diagnostic imaging; Colitis, Ulcerative - drug therapy; Colitis, Ulcerative - pathology; Colonoscopy - methods; Confidence Intervals; Digestive system. Abdomen; Dose-Response Relationship, Drug; Drug Administration Schedule; Endoscopy; Endosonography - methods; Female; Follow-Up Studies; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Intestinal Mucosa - drug effects; Intestinal Mucosa - pathology; Investigative techniques, diagnostic techniques (general aspects); Logistic Models; Male; Medical sciences; Odds Ratio; Other diseases. Semiology; Predictive Value of Tests; Prospective Studies; Recurrence; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Treatment Outcome; Young Adult; Short term; Prognosis; Treatment; Colonoscopy; Gastroenterology; Digestive diseases; Intestinal disease; Endoscopy; Ultrasound; Inflammatory disease; Ulcerative colitis

Mucosal healing has been proposed as an important sign of the efficacy of medical treatment of inflammatory bowel disease; however, direct evidence in ulcerative colitis (UC) is scarce. We evaluated the usefulness of colonoscopy and bowel ultrasound (US) as indexes of response to short-term therapy...