Broad Repertoire of the CD4+ Th Cell Response in Spontaneously Controlled Hepatitis C Virus Infection Includes Dominant and Highly Promiscuous Epitopes

• Published in: The Journal of immunology (1950) Vol. 175; no. 6; pp. 3603 - 3613
• Main Authors: Schulze zur Wiesch, Julian, Lauer, Georg M, Day, Cheryl L, Kim, Arthur Y, Ouchi, Kei, Duncan, Jared E, Wurcel, Alysse G, Timm, Joerg, Jones, Andrea M, Mothe, Bianca, Allen, Todd M, McGovern, Barbara, Lewis-Ximenez, Lia, Sidney, John, Sette, Alessandro, Chung, Raymond T, Walker, Bruce D
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.09.2005
• Subjects: Cells, Cultured; Chronic Disease; Epitopes, T-Lymphocyte - immunology; Hepatitis C - immunology; Histocompatibility Antigens Class II - immunology; HLA-DR Antigens - immunology; Humans; Immunodominant Epitopes - immunology; Remission, Spontaneous; T-Cell Antigen Receptor Specificity; T-Lymphocytes, Helper-Inducer - immunology; Viral Nonstructural Proteins - immunology; Viremia - immunology

A vigorous hepatitis C virus (HCV)-specific Th cell response is regarded as essential to the immunological control of HCV viremia. The aim of this study was to comprehensively define the breadth and specificity of dominant HCV-specific CD4+ T cell epitopes in large cohorts of subjects with chronic a...