Stem Cells, Including a Population of Very Small Embryonic-Like Stem Cells, are Mobilized Into Peripheral Blood in Patients After Skin Burn Injury

• Published in: Stem cell reviews Vol. 8; no. 1; pp. 184 - 194
• Main Authors: Drukała, Justyna, Paczkowska, Edyta, Kucia, Magda, Młyńska, Elżbieta, Krajewski, Andrzej, Machaliński, Bogusław, Madeja, Zbigniew, Ratajczak, Mariusz Z.
• Format: Journal Article
• Language: English
• Published: New York Humana Press Inc 01.03.2012; Springer Nature B.V
• Subjects: Adult; Age; Antigens, Differentiation - metabolism; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Burns; Case-Control Studies; CD34 antigen; Cell Biology; Chemokine CXCL12 - blood; CXCR4 protein; Data processing; Embryonic Stem Cells - metabolism; Embryonic Stem Cells - pathology; Endothelial Cells - metabolism; Endothelial Cells - pathology; Enzyme-linked immunosorbent assay; Epidermis - pathology; Female; Flow cytometry; Heart; Hematopoietic Stem Cells - metabolism; Hematopoietic Stem Cells - pathology; Hemopoiesis; Hepatocyte Growth Factor - blood; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Humans; Immunofluorescence; Injuries; Life Sciences; Male; Nanog Homeobox Protein; Oct-4 protein; Octamer Transcription Factor-3 - genetics; Octamer Transcription Factor-3 - metabolism; Peripheral blood; Phenotype; Receptors, CXCR4 - metabolism; Regenerative Medicine/Tissue Engineering; Reviews; SDF-1 protein; Skin; Stem Cells; Stroke; Sunburn - blood; Sunburn - pathology; Transduction, Genetic; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - blood; Skin burns; SDF-1; Stem cell mobilization; CXCR4; VSELs

Background Developmentally early cells, including hematopoietic stem progenitor cells (HSPCs), as well as very small embryonic-like stem cells (VSELs), are mobilized into peripheral blood (PB) in response to tissue and organ injury (e.g., heart infarct or stroke). Objective We seek to determine whet...