Roles of bacterial extracellular vesicles in systemic diseases

Accumulating evidence suggests that in various systems, not all bidirectional microbiota–host interactions involve direct cell contact. Bacterial extracellular vesicles (BEVs) may be key participants in this interkingdom crosstalk. BEVs mediate microbiota functions by delivering effector molecules t...

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Published inFrontiers in microbiology Vol. 14; p. 1258860
Main Authors Wang, Yanzhen, Luo, Xinghong, Xiang, Xiaozhen, Hao, Chunbo, Ma, Dandan
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 28.09.2023
Subjects
bacterial extracellular vesicles
interaction
membrane vesicles
Microbiology
outer membrane vesicles
pathogenesis
systemic diseases
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Summary:Accumulating evidence suggests that in various systems, not all bidirectional microbiota–host interactions involve direct cell contact. Bacterial extracellular vesicles (BEVs) may be key participants in this interkingdom crosstalk. BEVs mediate microbiota functions by delivering effector molecules that modulate host signaling pathways, thereby facilitating host–microbe interactions. BEV production during infections by both pathogens and probiotics has been observed in various host tissues. Therefore, these vesicles released by microbiota may have the ability to drive or inhibit disease pathogenesis in different systems within the host. Here, we review the current knowledge of BEVs and particularly emphasize their interactions with the host and the pathogenesis of systemic diseases.
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ORCID: Dandan Ma, https://orcid.org/0000-0003-4484-9455
Reviewed by: Dhiman Sankar Pal, Johns Hopkins University, United States; Martina Bielaszewska, National Institute of Public Health (NIPH), Czechia; Medicharla Venkata Jagannadham, University of Hyderabad, India
Edited by: Michal Letek, University of León, Spain
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2023.1258860