Roles of bacterial extracellular vesicles in systemic diseases
Accumulating evidence suggests that in various systems, not all bidirectional microbiota–host interactions involve direct cell contact. Bacterial extracellular vesicles (BEVs) may be key participants in this interkingdom crosstalk. BEVs mediate microbiota functions by delivering effector molecules t...
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Published in | Frontiers in microbiology Vol. 14; p. 1258860 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
28.09.2023
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Subjects | |
Online Access | Get full text |
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Summary: | Accumulating evidence suggests that in various systems, not all bidirectional microbiota–host interactions involve direct cell contact. Bacterial extracellular vesicles (BEVs) may be key participants in this interkingdom crosstalk. BEVs mediate microbiota functions by delivering effector molecules that modulate host signaling pathways, thereby facilitating host–microbe interactions. BEV production during infections by both pathogens and probiotics has been observed in various host tissues. Therefore, these vesicles released by microbiota may have the ability to drive or inhibit disease pathogenesis in different systems within the host. Here, we review the current knowledge of BEVs and particularly emphasize their interactions with the host and the pathogenesis of systemic diseases. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ORCID: Dandan Ma, https://orcid.org/0000-0003-4484-9455 Reviewed by: Dhiman Sankar Pal, Johns Hopkins University, United States; Martina Bielaszewska, National Institute of Public Health (NIPH), Czechia; Medicharla Venkata Jagannadham, University of Hyderabad, India Edited by: Michal Letek, University of León, Spain |
ISSN: | 1664-302X 1664-302X |
DOI: | 10.3389/fmicb.2023.1258860 |