Ghrelin inhibits insulin release by regulating the expression of inwardly rectifying potassium channel 6.2 in islets

• Published in: The American journal of the medical sciences Vol. 343; no. 3; p. 215
• Main Authors: Peng, Zhang, Xiaolei, Zhou, Al-Sanaban, Hani, Chengrui, Xue, Shengyi, You
• Format: Journal Article
• Language: English
• Published: United States 01.03.2012
• Subjects: Animals; Blood Glucose - analysis; Calcium - metabolism; Gene Expression Regulation - drug effects; Ghrelin - pharmacology; Insulin - metabolism; Insulin Secretion; Islets of Langerhans - metabolism; Male; Membrane Potentials; Potassium Channels, Inwardly Rectifying - analysis; Potassium Channels, Inwardly Rectifying - genetics; Rats; Rats, Wistar; Receptors, Ghrelin - physiology; RNA, Messenger - analysis

The objective is to investigate the influence of ghrelin administration on both the insulin secretion and the expression of ATP-sensitive K(+) channels in islet. Ghrelin and [D-Lys] growth hormone releasing peptide-6 were administered via intraperitoneal injection in Wistar rats at the doses 10 and...