Blood pool activity on F-18 FDG PET/CT as a possible imaging biomarker of metabolic syndrome

• Published in: Scientific reports Vol. 10; no. 1; p. 17367
• Main Authors: Bang, Ji-In, Moon, Chang Mo, Kim, Hye Ok, Kang, Seo Young, Yoon, Hai-Jeon, Kim, Bom Sahn
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.10.2020
• Subjects: 692/163; 692/4017; Adult; Aged; Biomarkers - blood; Female; Fluorodeoxyglucose F18 - administration & dosage; Humanities and Social Sciences; Humans; Male; Metabolic Syndrome - blood; Metabolic Syndrome - diagnostic imaging; Middle Aged; multidisciplinary; Positron Emission Tomography Computed Tomography - methods; Radiopharmaceuticals - administration & dosage; Retrospective Studies; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-74443-9

Association of blood pool (BP) and adipose tissue activity from F-18 fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) with the parameters of metabolic syndrome (MetS) and different MetS/obesity types were investigated. 245 subjects underwent FDG PET/CT scan for health check-ups were investigated retrospectively. Associations of BP (BP SUV: SUV max , SUV mean ), visceral (VAT SUV), and subcutaneous adipose tissue (SAT SUV) activity with parameters of MetS, body mass index (BMI), and lipid profiles were analyzed. MetS/obesity types were subdivided into metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO). BP SUV was higher in subjects with MetS (t-test, P < 0.005), and was associated with MetS from multivariable binary logistic regression (OR 5.232 P = 0.010). BP SUV was statistically higher in MUO than in MHO (P < 0.05) along with blood pressure, triglycerides, and HDL-cholesterol. Multivariable binary logistic regression analysis showed MUO had higher blood pressure and BP SUV, while lower HDL-cholesterol relative to MHO after adjusting for triglycerides.