Impaired CBS-H2S signaling axis contributes to MPTP-induced neurodegeneration in a mouse model of Parkinson’s disease

• Published in: Brain, behavior, and immunity Vol. 67; pp. 77 - 90
• Main Authors: Yuan, Yu-Qing, Wang, Ya-Li, Yuan, Bao-Shi, Yuan, Xin, Hou, Xiao-Ou, Bian, Jin-Song, Liu, Chun-Feng, Hu, Li-Fang
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.01.2018
• Subjects: Cystathionine β-synthase; Hydrogen sulfide; Neuroinflammation; Nitrative stress; Parkinson’s disease; α-Synuclein nitration; Hydrogen sulfide; Neuroinflammation; α-Synuclein nitration; Cystathionine β-synthase; Parkinson’s disease; Nitrative stress

•Plasma and striatal sulfide levels were decreased in MPTP-induced PD mouse model.•CBS expression was reduced in the striatum and glial cells of MPTP-treated mice.•Striatal CBS overexpression rescued MPTP-induced motor deficits and DA neuron losses.•CBS overexpression reduced the MPTP-induced nitrat...