CaMKIIβ in Neuronal Development and Plasticity: An Emerging Candidate in Brain Diseases

• Published in: International journal of molecular sciences Vol. 21; no. 19; p. 7272
• Main Authors: Nicole, Olivier, Pacary, Emilie
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.10.2020; MDPI
• Subjects: Animals; Binding sites; Brain - enzymology; Brain - physiopathology; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - chemistry; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism; Cell Movement; Gene Expression Regulation; Humans; Isoenzymes - chemistry; Isoenzymes - genetics; Isoenzymes - metabolism; Kinases; Life Sciences; Memory - physiology; Mental Disorders - enzymology; Mental Disorders - genetics; Mental Disorders - physiopathology; Mutation; Neurobiology; Neurodevelopmental Disorders - enzymology; Neurodevelopmental Disorders - genetics; Neurodevelopmental Disorders - physiopathology; Neuronal Plasticity - physiology; Neurons; Neurons - enzymology; Neurons - ultrastructure; Neurons and Cognition; Proteins; Review; Signal Transduction; Synapses - enzymology; Synapses - ultrastructure; neuronal development; neuronal plasticity; CaMKII; brain; neurodevelopmental disorders; psychiatric diseases

The calcium/calmodulin-dependent protein kinase II (CaMKII) is a ubiquitous and central player in Ca2+ signaling that is best known for its functions in the brain. In particular, the α isoform of CaMKII has been the subject of intense research and it has been established as a central regulator of ne...