Role of inhibition of osteogenesis function by Sema4D/Plexin-B1 signaling pathway in skeletal fluorosis in vitro

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 35; no. 5; pp. 712 - 715
• Main Authors: Liu, Xiao-li, Song, Jing, Liu, Ke-jian, Wang, Wen-peng, Xu, Chang, Zhang, Yu-zeng, Liu, Yun
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.10.2015; Zibo Center for Disease Control and Prevention, Zibo 255026, China%Department of Epidemiology and Biostatistics, Health Science Center, Peking University, Beijing 100191, China%Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
• Subjects: Animals; Antigens, CD - genetics; Antigens, CD - metabolism; Cell Proliferation - drug effects; Feedback, Physiological; Fetus; Fluorides - pharmacology; Gene Expression Regulation, Developmental; GTPase-Activating Proteins - genetics; GTPase-Activating Proteins - metabolism; Medicine; Medicine & Public Health; Osteoblasts - drug effects; Osteoblasts - metabolism; Osteoblasts - pathology; Osteoclasts - drug effects; Osteoclasts - metabolism; Osteoclasts - pathology; Osteogenesis - drug effects; Osteogenesis - genetics; Osteoprotegerin - genetics; Osteoprotegerin - metabolism; RANK Ligand - genetics; RANK Ligand - metabolism; Rats; Receptor Activator of Nuclear Factor-kappa B - genetics; Receptor Activator of Nuclear Factor-kappa B - metabolism; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; rho-Associated Kinases - genetics; rho-Associated Kinases - metabolism; rhoA GTP-Binding Protein - genetics; rhoA GTP-Binding Protein - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Semaphorins - genetics; Semaphorins - metabolism; Signal Transduction; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - metabolism; fluoride; osteoblast; osteoclast; skeletal fluorosis; semaphorin4D

Summary Skeletal fluorosis is a chronically metabolic bone disease with extensive hyperostosis osteosclerosis caused by long time exposure to fluoride. Skeletal fluorosis brings about a series of abnormal changes of the extremity, such as joint pain, joint stiffness, bone deformity, etc. Differentia...