Dose-dependent seizure control with MEK inhibitor therapy for progressive glioma in a child with neurofibromatosis type 1
Background Low-grade gliomas (LGGs) occurring in children can result in many different neurologic complications, including seizures. MEK inhibitors are increasingly being used to treat LGG, but their effect on associated neurologic symptoms has not been established. Results Here, we report a patient...
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Published in | Child's nervous system Vol. 38; no. 11; pp. 2245 - 2249 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.11.2022
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Abstract | Background
Low-grade gliomas (LGGs) occurring in children can result in many different neurologic complications, including seizures. MEK inhibitors are increasingly being used to treat LGG, but their effect on associated neurologic symptoms has not been established.
Results
Here, we report a patient with neurofibromatosis type 1 (NF1), medically refractory epilepsy (MRE), and an extensive optic pathway glioma (OPG) who developed dose-dependent seizure control while being treated with selumetinib. Seizure frequency rebounded after dose reduction for cardiac toxicity, then improved, and finally ceased after restarting full dosing, allowing confidence in the cause of improvement.
Conclusion
Selumetinib may have promise in epilepsy management in other children with NF1 or LGG. |
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AbstractList | BACKGROUNDLow-grade gliomas (LGGs) occurring in children can result in many different neurologic complications, including seizures. MEK inhibitors are increasingly being used to treat LGG, but their effect on associated neurologic symptoms has not been established. RESULTSHere, we report a patient with neurofibromatosis type 1 (NF1), medically refractory epilepsy (MRE), and an extensive optic pathway glioma (OPG) who developed dose-dependent seizure control while being treated with selumetinib. Seizure frequency rebounded after dose reduction for cardiac toxicity, then improved, and finally ceased after restarting full dosing, allowing confidence in the cause of improvement. CONCLUSIONSelumetinib may have promise in epilepsy management in other children with NF1 or LGG. Abstract Background Low-grade gliomas (LGGs) occurring in children can result in many different neurologic complications, including seizures. MEK inhibitors are increasingly being used to treat LGG, but their effect on associated neurologic symptoms has not been established. Results Here, we report a patient with neurofibromatosis type 1 (NF1), medically refractory epilepsy (MRE), and an extensive optic pathway glioma (OPG) who developed dose-dependent seizure control while being treated with selumetinib. Seizure frequency rebounded after dose reduction for cardiac toxicity, then improved, and finally ceased after restarting full dosing, allowing confidence in the cause of improvement. Conclusion Selumetinib may have promise in epilepsy management in other children with NF1 or LGG. Background Low-grade gliomas (LGGs) occurring in children can result in many different neurologic complications, including seizures. MEK inhibitors are increasingly being used to treat LGG, but their effect on associated neurologic symptoms has not been established. Results Here, we report a patient with neurofibromatosis type 1 (NF1), medically refractory epilepsy (MRE), and an extensive optic pathway glioma (OPG) who developed dose-dependent seizure control while being treated with selumetinib. Seizure frequency rebounded after dose reduction for cardiac toxicity, then improved, and finally ceased after restarting full dosing, allowing confidence in the cause of improvement. Conclusion Selumetinib may have promise in epilepsy management in other children with NF1 or LGG. Low-grade gliomas (LGGs) occurring in children can result in many different neurologic complications, including seizures. MEK inhibitors are increasingly being used to treat LGG, but their effect on associated neurologic symptoms has not been established. Here, we report a patient with neurofibromatosis type 1 (NF1), medically refractory epilepsy (MRE), and an extensive optic pathway glioma (OPG) who developed dose-dependent seizure control while being treated with selumetinib. Seizure frequency rebounded after dose reduction for cardiac toxicity, then improved, and finally ceased after restarting full dosing, allowing confidence in the cause of improvement. Selumetinib may have promise in epilepsy management in other children with NF1 or LGG. |
Author | Cantor, Evan Weisenberg, Judith L. Z. Meyer, Ashley Brossier, Nicole M. Morris, Stephanie M. |
Author_xml | – sequence: 1 givenname: Evan surname: Cantor fullname: Cantor, Evan organization: Department of Pediatrics, Washington University School of Medicine – sequence: 2 givenname: Ashley surname: Meyer fullname: Meyer, Ashley organization: Department of Pediatrics, Washington University School of Medicine – sequence: 3 givenname: Stephanie M. surname: Morris fullname: Morris, Stephanie M. organization: Department of Neurology, Washington University School of Medicine – sequence: 4 givenname: Judith L. Z. surname: Weisenberg fullname: Weisenberg, Judith L. Z. organization: Department of Neurology, Washington University School of Medicine – sequence: 5 givenname: Nicole M. orcidid: 0000-0002-4197-6283 surname: Brossier fullname: Brossier, Nicole M. email: nbrossier@wustl.edu organization: Department of Pediatrics, Washington University School of Medicine |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35648241$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/j.eplepsyres.2022.106890 10.2217/cns-2018-0007 10.1111/ejn.13652 10.1016/j.neuroscience.2008.07.010 10.1136/adc.67.2.178 10.1016/S0022-3476(95)70159-1 10.1146/annurev.genom.6.080604.162305 10.1111/epi.12348 10.1111/jnc.12982 10.1093/neuonc/noab047 10.1212/WNL.0000000000009458 10.1016/j.pharep.2018.02.021 10.1212/WNL.0000000000003881 10.1038/s41591-018-0172-x 10.1007/s00381-020-04710-7 10.1111/j.1468-1331.2010.03151.x 10.1093/cercor/bhaa413 10.1111/neup.12242 10.1038/ng.2646 10.1016/S1474-4422(07)70103-5 10.1038/sj.emboj.7601911 10.1016/S1470-2045(19)30277-3 10.3390/brainsci10050311 |
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Keywords | NF1 Seizure MEK inhibitor Selumetinib Epilepsy Neurofibromatosis |
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Low-grade gliomas (LGGs) occurring in children can result in many different neurologic complications, including seizures. MEK inhibitors are... Low-grade gliomas (LGGs) occurring in children can result in many different neurologic complications, including seizures. MEK inhibitors are increasingly being... Abstract Background Low-grade gliomas (LGGs) occurring in children can result in many different neurologic complications, including seizures. MEK inhibitors... BACKGROUNDLow-grade gliomas (LGGs) occurring in children can result in many different neurologic complications, including seizures. MEK inhibitors are... |
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SubjectTerms | Case Report Medicine Medicine & Public Health Neurosciences Neurosurgery |
Title | Dose-dependent seizure control with MEK inhibitor therapy for progressive glioma in a child with neurofibromatosis type 1 |
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