GABAergic drugs can enhance or attenuate chlordiazepoxide-induced sleep time in a heterogeneous strain of mice

• Published in: Pharmacology, biochemistry and behavior Vol. 25; no. 5; pp. 1077 - 1081
• Main Authors: McIntyre, Todd D., Alpern, Herbert P.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.11.1986; Elsevier Science
• Subjects: Acetates - pharmacology; Aminooxyacetic Acid - pharmacology; Animals; AOAA; Applied sciences; Bicuculline; Bicuculline - pharmacology; Biological and medical sciences; Chlordiazepoxide - pharmacology; Exact sciences and technology; GABA; GABA Antagonists; gamma-Aminobutyric Acid - physiology; Heterogeneous mice; Hypnotics. Sedatives; Medical sciences; Mice; Neuropharmacology; Other techniques and industries; Pentylenetetrazol; Pentylenetetrazole - pharmacology; Pharmacogenetics; Pharmacology. Drug treatments; Picrotoxin; Picrotoxin - pharmacology; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Sleep - drug effects; AOAA; Pharmacogenetics; Pentylenetetrazol; GABA; Heterogeneous mice; Picrotoxin; Bicuculline; Vertebrata; Mammalia; Sleep; Mouse; Animal; Gabaergic agonist; Rodentia; Gabaergic transmission; Drug interaction; Gabaergic antagonist

Evidence supports the notion that differences between the Long-Sleep and Short-Sleep selectively-bred lines of mice are attributable to differences in brain excitability and that these differences are mediated by activity of the GABAergic system. The general applicability of this hypothesis to other...