Oxidative stress induces senescence in human mesenchymal stem cells

• Published in: Experimental cell research Vol. 317; no. 11; pp. 1541 - 1547
• Main Authors: Brandl, Anita, Meyer, Matthias, Bechmann, Volker, Nerlich, Michael, Angele, Peter
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2011; Elsevier BV
• Subjects: 60 APPLIED LIFE SCIENCES; Adult; AGING; beta-galactosidase; beta-Galactosidase - metabolism; CELL PROLIFERATION; Cell Proliferation - drug effects; Cells, Cultured; Cellular biology; Cellular Senescence; chondrocytes; DNA damage; DNA DAMAGES; FIBROBLASTS; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; GALACTOSIDASE; gene expression; Gene Expression Profiling; Human mesenchymal stem cells; Humans; HYDROGEN PEROXIDE; Hydrogen Peroxide - pharmacology; IN VIVO; LETHAL DOSES; Mesenchymal Stromal Cells - metabolism; MONOCLINIC LATTICES; oxidants; Oxidants - pharmacology; OXIDATION; Oxidative Stress; PHOSPHATES; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; SODIUM COMPOUNDS; STEM CELLS; stress response; stress tolerance; Telomere; Telomeres; tissue engineering; tissue repair; Up-Regulation; Oxidative stress; SSC; DNA damage; Cellular senescence; TRF; Human mesenchymal stem cells; SAβ-gal; SD; Telomeres; MSCs; cpd; DPBS; SIRT

Mesenchymal stem cells (MSCs) contribute to tissue repair in vivo and form an attractive cell source for tissue engineering. Their regenerative potential is impaired by cellular senescence. The effects of oxidative stress on MSCs are still unknown. Our studies were to investigate into the proliferat...