Oxidative stress induces senescence in human mesenchymal stem cells - Brandl, Anita; Meyer, Matthias; Bechmann, Volker; Nerlich, Michael; Angele, Peter (Experimental cell research, 2011)
Keywords: 60 APPLIED LIFE SCIENCES; Adult; AGING; beta-galactosidase; beta-Galactosidase - metabolism; CELL PROLIFERATION; Cell Proliferation - drug effects; Cells, Cultured; Cellular biology; Cellular Senescence; chondrocytes; DNA damage; DNA DAMAGES; FIBROBLASTS; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; GALACTOSIDASE; gene expression; Gene Expression Profiling; Human mesenchymal stem cells; Humans; HYDROGEN PEROXIDE; Hydrogen Peroxide - pharmacology; IN VIVO; LETHAL DOSES; Mesenchymal Stromal Cells - metabolism; MONOCLINIC LATTICES; oxidants; Oxidants - pharmacology; OXIDATION; Oxidative Stress; PHOSPHATES; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; SODIUM COMPOUNDS; STEM CELLS; stress response; stress tolerance; Telomere; Telomeres; tissue engineering; tissue repair; Up-Regulation; Oxidative stress; SSC; DNA damage; Cellular senescence; TRF; Human mesenchymal stem cells; SAβ-gal; SD; Telomeres; MSCs; cpd; DPBS; SIRT