It's Insulin

• Published in: Journal of autoimmunity Vol. 15; no. 3; pp. 286 - 291
• Main Authors: Wegmann, Dale R., Eisenbarth, George S.
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 01.11.2000; Elsevier
• Subjects: Animals; Autoantibodies - immunology; Biological and medical sciences; Diabetes Mellitus, Type 1 - enzymology; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 1 - therapy; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; GAD65 antigen; Gene Targeting; Glutamate Decarboxylase - genetics; Glutamate Decarboxylase - immunology; Humans; Immunotherapy; Insulin - biosynthesis; Insulin - immunology; Islets of Langerhans - immunology; Isoenzymes - genetics; Isoenzymes - immunology; Medical sciences; Mice; Mice, Inbred NOD; Mice, Transgenic; RNA, Antisense; RNA, Messenger; T-Lymphocytes - immunology; Thymus Gland - metabolism; Endocrinopathy; Pancreatic hormone; Autoimmune disease; Lyases; Cellular immunity; Protein hormone; B-Cell; Carboxy-lyases; T-Lymphocyte; Humoral immunity; Endocrine pancreas; Human; Immunopathology; Immune response; Enzyme; Antibody; Rodentia; Langerhans islet; Autoantibody; Glutamate decarboxylase; Insulin; Antigen; Carbon-carbon lyases; Vertebrata; Mammalia; Autoantigen; Mouse; Animal; Insulin dependent diabetes

The realization that the majority of cases of insulin dependent diabetes mellitus (IDDM) are of an autoimmune etiology has led to an interest in the identification of antigens that are recognized in this proceess. Experimental evidence accumulated from human subject and the non-obese diabetic (NOD)...