Applications of MALDI mass spectrometry imaging for pharmacokinetic studies during drug development

• Published in: Drug metabolism and pharmacokinetics Vol. 34; no. 4; pp. 209 - 216
• Main Authors: Nishidate, Masanobu, Hayashi, Mitsuhiro, Aikawa, Hiroaki, Tanaka, Kouji, Nakada, Naoyuki, Miura, Shin-ichi, Ryu, Shoraku, Higashi, Tatsuya, Ikarashi, Yoshinori, Fujiwara, Yasuhiro, Hamada, Akinobu
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2019
• Subjects: Animals; Application; Drug; Drug Development - methods; Humans; LC-MS/MS; MALDI; Mass spectrometry imaging; Pharmaceutical Preparations - analysis; Pharmacokinetics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Standardization; Validation; Validation; Drug; LC-MS/MS; MALDI; Mass spectrometry imaging; Standardization; Pharmacokinetics; Application

The concentration and distribution of a drug or its metabolites in tissues are key factors for understanding drug efficacy or toxicity. Conventional pharmacokinetic studies show that the plasma concentration of a drug is often unrelated to the intra-tissue concentration. Moreover, it is difficult to...