Applications of MALDI mass spectrometry imaging for pharmacokinetic studies during drug development
The concentration and distribution of a drug or its metabolites in tissues are key factors for understanding drug efficacy or toxicity. Conventional pharmacokinetic studies show that the plasma concentration of a drug is often unrelated to the intra-tissue concentration. Moreover, it is difficult to...
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| Published in | Drug metabolism and pharmacokinetics Vol. 34; no. 4; pp. 209 - 216 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.08.2019
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| Abstract | The concentration and distribution of a drug or its metabolites in tissues are key factors for understanding drug efficacy or toxicity. Conventional pharmacokinetic studies show that the plasma concentration of a drug is often unrelated to the intra-tissue concentration. Moreover, it is difficult to predict the distribution of a drug in tissues, particularly those with complex structures, even though the overall tissue concentration is measured by using homogenizing procedures. Mass spectrometry imaging (MSI) enables visualization of the spatial distribution and quantities of drugs in tissue sections without labeling, which can significantly impact on the development of new drugs and translational research. Recent advances in instrument technology and the knowledge accumulated to date could further improve the sensitivity, spatial resolution, and reproducibility of MSI. Here we present current applications of matrix-assisted laser desorption/ionization (MALDI)-MSI in pharmacokinetic imaging (PK-imaging) studies, give an overview of MALDI-MSI procedures, highlight the importance of internal standards, and give details of quantitative approaches. We also point out the need for standardizing MALDI-MSI techniques. PK-imaging using standardized MALDI-MSI methods, independent of instrument or technician expertise, is expected to contribute to acquiring reliable data in drug development and translational research in the future.
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| AbstractList | The concentration and distribution of a drug or its metabolites in tissues are key factors for understanding drug efficacy or toxicity. Conventional pharmacokinetic studies show that the plasma concentration of a drug is often unrelated to the intra-tissue concentration. Moreover, it is difficult to predict the distribution of a drug in tissues, particularly those with complex structures, even though the overall tissue concentration is measured by using homogenizing procedures. Mass spectrometry imaging (MSI) enables visualization of the spatial distribution and quantities of drugs in tissue sections without labeling, which can significantly impact on the development of new drugs and translational research. Recent advances in instrument technology and the knowledge accumulated to date could further improve the sensitivity, spatial resolution, and reproducibility of MSI. Here we present current applications of matrix-assisted laser desorption/ionization (MALDI)-MSI in pharmacokinetic imaging (PK-imaging) studies, give an overview of MALDI-MSI procedures, highlight the importance of internal standards, and give details of quantitative approaches. We also point out the need for standardizing MALDI-MSI techniques. PK-imaging using standardized MALDI-MSI methods, independent of instrument or technician expertise, is expected to contribute to acquiring reliable data in drug development and translational research in the future.
[Display omitted] The concentration and distribution of a drug or its metabolites in tissues are key factors for understanding drug efficacy or toxicity. Conventional pharmacokinetic studies show that the plasma concentration of a drug is often unrelated to the intra-tissue concentration. Moreover, it is difficult to predict the distribution of a drug in tissues, particularly those with complex structures, even though the overall tissue concentration is measured by using homogenizing procedures. Mass spectrometry imaging (MSI) enables visualization of the spatial distribution and quantities of drugs in tissue sections without labeling, which can significantly impact on the development of new drugs and translational research. Recent advances in instrument technology and the knowledge accumulated to date could further improve the sensitivity, spatial resolution, and reproducibility of MSI. Here we present current applications of matrix-assisted laser desorption/ionization (MALDI)-MSI in pharmacokinetic imaging (PK-imaging) studies, give an overview of MALDI-MSI procedures, highlight the importance of internal standards, and give details of quantitative approaches. We also point out the need for standardizing MALDI-MSI techniques. PK-imaging using standardized MALDI-MSI methods, independent of instrument or technician expertise, is expected to contribute to acquiring reliable data in drug development and translational research in the future. The concentration and distribution of a drug or its metabolites in tissues are key factors for understanding drug efficacy or toxicity. Conventional pharmacokinetic studies show that the plasma concentration of a drug is often unrelated to the intra-tissue concentration. Moreover, it is difficult to predict the distribution of a drug in tissues, particularly those with complex structures, even though the overall tissue concentration is measured by using homogenizing procedures. Mass spectrometry imaging (MSI) enables visualization of the spatial distribution and quantities of drugs in tissue sections without labeling, which can significantly impact on the development of new drugs and translational research. Recent advances in instrument technology and the knowledge accumulated to date could further improve the sensitivity, spatial resolution, and reproducibility of MSI. Here we present current applications of matrix-assisted laser desorption/ionization (MALDI)-MSI in pharmacokinetic imaging (PK-imaging) studies, give an overview of MALDI-MSI procedures, highlight the importance of internal standards, and give details of quantitative approaches. We also point out the need for standardizing MALDI-MSI techniques. PK-imaging using standardized MALDI-MSI methods, independent of instrument or technician expertise, is expected to contribute to acquiring reliable data in drug development and translational research in the future.The concentration and distribution of a drug or its metabolites in tissues are key factors for understanding drug efficacy or toxicity. Conventional pharmacokinetic studies show that the plasma concentration of a drug is often unrelated to the intra-tissue concentration. Moreover, it is difficult to predict the distribution of a drug in tissues, particularly those with complex structures, even though the overall tissue concentration is measured by using homogenizing procedures. Mass spectrometry imaging (MSI) enables visualization of the spatial distribution and quantities of drugs in tissue sections without labeling, which can significantly impact on the development of new drugs and translational research. Recent advances in instrument technology and the knowledge accumulated to date could further improve the sensitivity, spatial resolution, and reproducibility of MSI. Here we present current applications of matrix-assisted laser desorption/ionization (MALDI)-MSI in pharmacokinetic imaging (PK-imaging) studies, give an overview of MALDI-MSI procedures, highlight the importance of internal standards, and give details of quantitative approaches. We also point out the need for standardizing MALDI-MSI techniques. PK-imaging using standardized MALDI-MSI methods, independent of instrument or technician expertise, is expected to contribute to acquiring reliable data in drug development and translational research in the future. |
| Author | Aikawa, Hiroaki Hayashi, Mitsuhiro Tanaka, Kouji Hamada, Akinobu Nakada, Naoyuki Ryu, Shoraku Higashi, Tatsuya Miura, Shin-ichi Ikarashi, Yoshinori Nishidate, Masanobu Fujiwara, Yasuhiro |
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| Cites_doi | 10.1021/acs.analchem.5b04409 10.1021/acs.chemrestox.5b00262 10.1007/s13361-015-1254-3 10.4155/bio-2015-0020 10.1016/j.jprot.2012.07.034 10.1038/srep37027 10.1111/bph.14067 10.1016/j.jprot.2012.07.035 10.1038/s41598-017-18702-2 10.1021/acs.analchem.8b00985 10.1038/srep33791 10.1038/nm.3937 10.1021/ac202630t 10.1038/clpt.2014.105 10.1007/s13361-015-1103-4 10.1124/dmd.113.055434 10.1007/s13361-016-1501-2 10.1016/j.bbapap.2016.12.011 10.1021/ac400892z 10.1021/ac504734s 10.1038/srep23749 10.4155/bio.11.232 10.1255/ejms.1254 10.1007/s00216-017-0443-2 10.1021/acs.analchem.7b05005 10.1038/srep03050 10.1007/s00216-014-8410-7 10.1016/j.addr.2013.04.009 10.1002/cpt.786 10.1007/s00216-014-8315-5 10.5702/massspectrometry.A0025 10.1177/1087057115623740 10.1021/ac1029049 10.1021/ac3015142 10.1293/tox.2018-0006 10.1074/jbc.R111.225854 10.1038/nmeth.4071 10.1016/j.jasms.2009.12.014 10.1021/ac201767g 10.1002/prca.201800029 10.4155/bio.12.187 10.1007/s00216-018-0964-3 10.1038/s41598-017-17211-6 10.1016/j.talanta.2016.12.049 10.1007/s11481-009-9162-6 10.1021/ac200610c 10.1007/s13361-012-0505-9 10.1007/s00418-015-1382-7 10.1371/journal.pone.0011411 10.1038/nmeth.4433 10.1038/86573 10.1007/s00216-011-4929-z 10.1093/toxsci/kfx044 10.1016/j.mad.2004.09.032 10.1038/s41598-017-13025-8 10.1038/srep39284 10.4155/bio.14.34 10.1016/j.jprot.2012.07.028 10.1021/ac302960j |
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| Copyright | 2019 The Japanese Society for the Study of Xenobiotics Copyright © 2019 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved. |
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| References | Kashimura (bib4) 2018; 31 Lietz, Gemperline, Li (bib10) 2013; 65 Lenz (bib58) 2018; 163 Aikawa (bib38) 2016; 6 Kompauer, Heiles, Spengler (bib18) 2017; 14 Seeley, Schwamborn, Caprioli (bib8) 2011; 286 Castellino, Groseclose, Wagner (bib15) 2011; 3 Shahidi-Latham (bib59) 2012; 84 Taylor, Dexter, Bunch (bib55) 2018; 90 Giordano (bib36) 2016; 6 Robichaud (bib11) 2013; 24 Yasunaga (bib16) 2013; 3 Bennet, Gamage, Fernandez (bib7) 2013 Pirman (bib33) 2013; 85 Bruinen (bib50) 2016; 27 Groseclose, Castellino (bib21) 2013; 85 Blanc (bib60) 2018; 90 Giordano (bib56) 2016; 6 Kallback (bib27) 2012; 75 Rohner, Staab, Stoeckli (bib22) 2005; 126 Prideaux (bib12) 2011; 83 Goodwin (bib49) 2016; 21 Fulop (bib54) 2016; 6 Takai, Tanaka, Saji (bib29) 2014; 3 Prentice, Chumbley, Caprioli (bib44) 2017; 28 Porta (bib26) 2015; 407 Timmerman (bib48) 2014; 6 Nishidate (bib3) 2017; 7 Goodwin (bib30) 2011; 83 Morosi (bib53) 2017; 102 Prideaux (bib39) 2015; 21 Sugiura, Setou (bib6) 2010; 5 Ryu (bib23) 2018; 175 Nilsson (bib14) 2015; 87 Ly (bib42) 2019; 13 Christensen (bib51) 2014; 42 EMA (bib46) 2012 Stauber (bib19) 2012; 4 FDA (bib47) 2018 Sun (bib32) 2016; 145 Rompp (bib41) 2015; 407 Hamm (bib25) 2012; 75 Bonnel (bib61) 2018; 410 Stoeckli (bib5) 2001; 7 Reich (bib34) 2010; 21 Kompauer, Heiles, Spengler (bib17) 2017; 14 Prideaux, Stoeckli (bib1) 2012; 75 MHLW (bib45) 2013 Zecchi (bib62) 2013; 19 Porta (bib13) 2011; 83 Rao (bib43) 2017; 165 Deininger (bib20) 2011; 401 Groseclose (bib28) 2015; 26 Chumbley (bib37) 2016; 88 Tsubata (bib40) 2017; 7 Fuso Nerini (bib2) 2014; 96 Tanaka (bib52) 2018; 8 Nilsson (bib57) 2015; 28 Sorensen (bib63) 2017; 409 Sugihara, Watanabe, Vegvari (bib9) 2016; 8 Fonville (bib24) 2012; 84 Nilsson (bib35) 2010; 5 Rzagalinski, Volmer (bib31) 2017; 1865 Castellino (10.1016/j.dmpk.2019.04.006_bib15) 2011; 3 Shahidi-Latham (10.1016/j.dmpk.2019.04.006_bib59) 2012; 84 Prideaux (10.1016/j.dmpk.2019.04.006_bib39) 2015; 21 Fuso Nerini (10.1016/j.dmpk.2019.04.006_bib2) 2014; 96 Sorensen (10.1016/j.dmpk.2019.04.006_bib63) 2017; 409 Sugihara (10.1016/j.dmpk.2019.04.006_bib9) 2016; 8 Giordano (10.1016/j.dmpk.2019.04.006_bib36) 2016; 6 Bennet (10.1016/j.dmpk.2019.04.006_bib7) 2013 Robichaud (10.1016/j.dmpk.2019.04.006_bib11) 2013; 24 Rzagalinski (10.1016/j.dmpk.2019.04.006_bib31) 2017; 1865 Fonville (10.1016/j.dmpk.2019.04.006_bib24) 2012; 84 EMA (10.1016/j.dmpk.2019.04.006_bib46) 2012 Rompp (10.1016/j.dmpk.2019.04.006_bib41) 2015; 407 Chumbley (10.1016/j.dmpk.2019.04.006_bib37) 2016; 88 Reich (10.1016/j.dmpk.2019.04.006_bib34) 2010; 21 Zecchi (10.1016/j.dmpk.2019.04.006_bib62) 2013; 19 Prentice (10.1016/j.dmpk.2019.04.006_bib44) 2017; 28 Sugiura (10.1016/j.dmpk.2019.04.006_bib6) 2010; 5 Kompauer (10.1016/j.dmpk.2019.04.006_bib17) 2017; 14 Rohner (10.1016/j.dmpk.2019.04.006_bib22) 2005; 126 Sun (10.1016/j.dmpk.2019.04.006_bib32) 2016; 145 Fulop (10.1016/j.dmpk.2019.04.006_bib54) 2016; 6 Ryu (10.1016/j.dmpk.2019.04.006_bib23) 2018; 175 Prideaux (10.1016/j.dmpk.2019.04.006_bib12) 2011; 83 Kallback (10.1016/j.dmpk.2019.04.006_bib27) 2012; 75 Deininger (10.1016/j.dmpk.2019.04.006_bib20) 2011; 401 FDA (10.1016/j.dmpk.2019.04.006_bib47) 2018 Nilsson (10.1016/j.dmpk.2019.04.006_bib35) 2010; 5 Aikawa (10.1016/j.dmpk.2019.04.006_bib38) 2016; 6 Stauber (10.1016/j.dmpk.2019.04.006_bib19) 2012; 4 Pirman (10.1016/j.dmpk.2019.04.006_bib33) 2013; 85 Stoeckli (10.1016/j.dmpk.2019.04.006_bib5) 2001; 7 Groseclose (10.1016/j.dmpk.2019.04.006_bib21) 2013; 85 Nilsson (10.1016/j.dmpk.2019.04.006_bib57) 2015; 28 Bruinen (10.1016/j.dmpk.2019.04.006_bib50) 2016; 27 Lenz (10.1016/j.dmpk.2019.04.006_bib58) 2018; 163 Ly (10.1016/j.dmpk.2019.04.006_bib42) 2019; 13 Lietz (10.1016/j.dmpk.2019.04.006_bib10) 2013; 65 Timmerman (10.1016/j.dmpk.2019.04.006_bib48) 2014; 6 Hamm (10.1016/j.dmpk.2019.04.006_bib25) 2012; 75 Rao (10.1016/j.dmpk.2019.04.006_bib43) 2017; 165 Christensen (10.1016/j.dmpk.2019.04.006_bib51) 2014; 42 Takai (10.1016/j.dmpk.2019.04.006_bib29) 2014; 3 Nishidate (10.1016/j.dmpk.2019.04.006_bib3) 2017; 7 Porta (10.1016/j.dmpk.2019.04.006_bib13) 2011; 83 Tsubata (10.1016/j.dmpk.2019.04.006_bib40) 2017; 7 Giordano (10.1016/j.dmpk.2019.04.006_bib56) 2016; 6 Yasunaga (10.1016/j.dmpk.2019.04.006_bib16) 2013; 3 Goodwin (10.1016/j.dmpk.2019.04.006_bib49) 2016; 21 Morosi (10.1016/j.dmpk.2019.04.006_bib53) 2017; 102 Prideaux (10.1016/j.dmpk.2019.04.006_bib1) 2012; 75 Kashimura (10.1016/j.dmpk.2019.04.006_bib4) 2018; 31 Bonnel (10.1016/j.dmpk.2019.04.006_bib61) 2018; 410 Seeley (10.1016/j.dmpk.2019.04.006_bib8) 2011; 286 Nilsson (10.1016/j.dmpk.2019.04.006_bib14) 2015; 87 Goodwin (10.1016/j.dmpk.2019.04.006_bib30) 2011; 83 MHLW (10.1016/j.dmpk.2019.04.006_bib45) 2013 Taylor (10.1016/j.dmpk.2019.04.006_bib55) 2018; 90 Tanaka (10.1016/j.dmpk.2019.04.006_bib52) 2018; 8 Blanc (10.1016/j.dmpk.2019.04.006_bib60) 2018; 90 Porta (10.1016/j.dmpk.2019.04.006_bib26) 2015; 407 Kompauer (10.1016/j.dmpk.2019.04.006_bib18) 2017; 14 Groseclose (10.1016/j.dmpk.2019.04.006_bib28) 2015; 26 |
| References_xml | – volume: 5 start-page: 31 year: 2010 end-page: 43 ident: bib6 article-title: Imaging mass spectrometry for visualization of drug and endogenous metabolite distribution: toward in situ pharmacometabolomes publication-title: J Neuroimmune Pharmacol – volume: 84 start-page: 1310 year: 2012 end-page: 1319 ident: bib24 article-title: Robust data processing and normalization strategy for MALDI mass spectrometric imaging publication-title: Anal Chem – volume: 21 start-page: 564 year: 2010 end-page: 571 ident: bib34 article-title: Quantitative MALDI-MS(n) analysis of cocaine in the autopsied brain of a human cocaine user employing a wide isolation window and internal standards publication-title: J Am Soc Mass Spectrom – volume: 96 start-page: 224 year: 2014 end-page: 238 ident: bib2 article-title: Intratumor heterogeneity and its impact on drug distribution and sensitivity publication-title: Clin Pharmacol Ther – volume: 90 start-page: 6275 year: 2018 end-page: 6282 ident: bib60 article-title: Visualization of mycobacterial biomarkers and tuberculosis drugs in infected tissue by MALDI-MS imaging publication-title: Anal Chem – volume: 4 start-page: 2095 year: 2012 end-page: 2098 ident: bib19 article-title: Quantitation by MS imaging: needs and challenges in pharmaceuticals publication-title: Bioanalysis – volume: 102 start-page: 748 year: 2017 end-page: 751 ident: bib53 article-title: Application of 3D mass spectrometry imaging to TKIs publication-title: Clin Pharmacol Ther – volume: 14 start-page: 1156 year: 2017 end-page: 1158 ident: bib17 article-title: Autofocusing MALDI mass spectrometry imaging of tissue sections and 3D chemical topography of nonflat surfaces publication-title: Nat Methods – volume: 165 start-page: 128 year: 2017 end-page: 135 ident: bib43 article-title: Optimization and evaluation of MALDI TOF mass spectrometric imaging for quantification of orally dosed octreotide in mouse tissues publication-title: Talanta – volume: 21 start-page: 1223 year: 2015 end-page: 1227 ident: bib39 article-title: The association between sterilizing activity and drug distribution into tuberculosis lesions publication-title: Nat Med – volume: 27 start-page: 117 year: 2016 end-page: 123 ident: bib50 article-title: Mass spectrometry imaging of drug related crystal-like structures in formalin-fixed frozen and paraffin-embedded rabbit kidney tissue sections publication-title: J Am Soc Mass Spectrom – volume: 75 start-page: 4999 year: 2012 end-page: 5013 ident: bib1 article-title: Mass spectrometry imaging for drug distribution studies publication-title: J Proteomics – volume: 6 start-page: 39284 year: 2016 ident: bib36 article-title: Heterogeneity of paclitaxel distribution in different tumor models assessed by MALDI mass spectrometry imaging publication-title: Sci Rep – volume: 175 start-page: 29 year: 2018 end-page: 37 ident: bib23 article-title: Heterogeneous distribution of alectinib in neuroblastoma xenografts revealed by matrix-assisted laser desorption ionization mass spectrometry imaging: a pilot study publication-title: Br J Pharmacol – volume: 8 start-page: 343 year: 2018 ident: bib52 article-title: Distribution analysis of epertinib in brain metastasis of HER2-positive breast cancer by imaging mass spectrometry and prospect for antitumor activity publication-title: Sci Rep – volume: 410 start-page: 2815 year: 2018 end-page: 2828 ident: bib61 article-title: MALDI imaging facilitates new topical drug development process by determining quantitative skin distribution profiles publication-title: Anal Bioanal Chem – volume: 407 start-page: 2329 year: 2015 end-page: 2335 ident: bib41 article-title: Mass spectrometry imaging of biological tissue: an approach for multicenter studies publication-title: Anal Bioanal Chem – volume: 8 start-page: 575 year: 2016 end-page: 588 ident: bib9 article-title: Novel insights in drug metabolism by MS imaging publication-title: Bioanalysis – volume: 75 start-page: 4941 year: 2012 end-page: 4951 ident: bib27 article-title: Novel mass spectrometry imaging software assisting labeled normalization and quantitation of drugs and neuropeptides directly in tissue sections publication-title: J Proteomics – volume: 87 start-page: 1437 year: 2015 end-page: 1455 ident: bib14 article-title: Mass spectrometry imaging in drug development publication-title: Anal Chem – volume: 3 start-page: 2427 year: 2011 end-page: 2441 ident: bib15 article-title: MALDI imaging mass spectrometry: bridging biology and chemistry in drug development publication-title: Bioanalysis – volume: 1865 start-page: 726 year: 2017 end-page: 739 ident: bib31 article-title: Quantification of low molecular weight compounds by MALDI imaging mass spectrometry - a tutorial review publication-title: Biochim Biophys Acta Protein Proteonomics – volume: 75 start-page: 4952 year: 2012 end-page: 4961 ident: bib25 article-title: Quantitative mass spectrometry imaging of propranolol and olanzapine using tissue extinction calculation as normalization factor publication-title: J Proteomics – volume: 407 start-page: 2177 year: 2015 end-page: 2187 ident: bib26 article-title: Quantification in MALDI-MS imaging: what can we learn from MALDI-selected reaction monitoring and what can we expect for imaging? publication-title: Anal Bioanal Chem – volume: 6 start-page: 33791 year: 2016 ident: bib54 article-title: Molecular imaging of brain localization of liposomes in mice using MALDI mass spectrometry publication-title: Sci Rep – year: 2018 ident: bib47 article-title: : bioanalytical method validation – volume: 42 start-page: 431 year: 2014 end-page: 440 ident: bib51 article-title: Biodistribution and metabolism studies of lipid nanoparticle-formulated internally [3H]-labeled siRNA in mice publication-title: Drug Metab Dispos – volume: 28 start-page: 136 year: 2017 end-page: 144 ident: bib44 article-title: Absolute quantification of rifampicin by MALDI imaging mass spectrometry using multiple TOF/TOF events in a single laser shot publication-title: J Am Soc Mass Spectrom – volume: 83 start-page: 4266 year: 2011 end-page: 4272 ident: bib13 article-title: Single hair cocaine consumption monitoring by mass spectrometric imaging publication-title: Anal Chem – year: 2013 ident: bib7 article-title: Imaging of biological tissues by desorption electrospray ionization mass spectrometry publication-title: J Vis Exp – volume: 6 start-page: 23749 year: 2016 ident: bib38 article-title: Visualizing spatial distribution of alectinib in murine brain using quantitative mass spectrometry imaging publication-title: Sci Rep – volume: 6 start-page: 37027 year: 2016 ident: bib56 article-title: 3D mass spectrometry imaging reveals a very heterogeneous drug distribution in tumors publication-title: Sci Rep – volume: 88 start-page: 2392 year: 2016 end-page: 2398 ident: bib37 article-title: Absolute quantitative MALDI imaging mass spectrometry: a case of rifampicin in liver tissues publication-title: Anal Chem – volume: 90 start-page: 5637 year: 2018 end-page: 5645 ident: bib55 article-title: Exploring ion suppression in mass spectrometry imaging of a heterogeneous tissue publication-title: Anal Chem – volume: 401 start-page: 167 year: 2011 end-page: 181 ident: bib20 article-title: Normalization in MALDI-TOF imaging datasets of proteins: practical considerations publication-title: Anal Bioanal Chem – volume: 145 start-page: 201 year: 2016 end-page: 211 ident: bib32 article-title: Pharmacokinetic and pharmacometabolomic study of pirfenidone in normal mouse tissues using high mass resolution MALDI-FTICR-mass spectrometry imaging publication-title: Histochem Cell Biol – volume: 85 start-page: 10099 year: 2013 end-page: 10106 ident: bib21 article-title: A mimetic tissue model for the quantification of drug distributions by MALDI imaging mass spectrometry publication-title: Anal Chem – volume: 26 start-page: 887 year: 2015 end-page: 898 ident: bib28 article-title: Imaging MS in toxicology: an investigation of juvenile rat nephrotoxicity associated with dabrafenib administration publication-title: J Am Soc Mass Spectrom – volume: 13 start-page: e1800029 year: 2019 ident: bib42 article-title: Site-to-Site reproducibility and spatial resolution in MALDI-MSI of peptides from formalin-fixed paraffin-embedded samples publication-title: Proteonomics Clin Appl – volume: 3 start-page: A0025 year: 2014 ident: bib29 article-title: Quantification of small molecule drugs in biological tissue sections by imaging mass spectrometry using surrogate tissue-based calibration standards publication-title: Mass Spectrom (Tokyo) – volume: 163 start-page: 409 year: 2018 end-page: 419 ident: bib58 article-title: Application of imaging techniques to cases of drug-induced crystal nephropathy in preclinical studies publication-title: Toxicol Sci – volume: 21 start-page: 187 year: 2016 end-page: 193 ident: bib49 article-title: Exemplifying the screening power of mass spectrometry imaging over label-based Technologies for simultaneous monitoring of drug and metabolite distributions in tissue sections publication-title: J Biomol Screen – volume: 7 start-page: 12622 year: 2017 ident: bib40 article-title: Evaluation of the heterogeneous tissue distribution of erlotinib in lung cancer using matrix-assisted laser desorption ionization mass spectrometry imaging publication-title: Sci Rep – volume: 28 start-page: 1823 year: 2015 end-page: 1830 ident: bib57 article-title: Investigating nephrotoxicity of polymyxin derivatives by mapping renal distribution using mass spectrometry imaging publication-title: Chem Res Toxicol – volume: 83 start-page: 9694 year: 2011 end-page: 9701 ident: bib30 article-title: Qualitative and quantitative MALDI imaging of the positron emission tomography ligands raclopride (a D2 dopamine antagonist) and SCH 23390 (a D1 dopamine antagonist) in rat brain tissue sections using a solvent-free dry matrix application method publication-title: Anal Chem – year: 2013 ident: bib45 article-title: Guideline on bioanalytical method validation in pharmaceutical development – year: 2012 ident: bib46 article-title: Guideline on bioanalytical method validation – volume: 31 start-page: 221 year: 2018 end-page: 227 ident: bib4 article-title: Imaging mass spectrometry for toxicity assessment: a useful technique to confirm drug distribution in histologically confirmed lesions publication-title: J Toxicol Pathol – volume: 85 start-page: 1081 year: 2013 end-page: 1089 ident: bib33 article-title: Quantitative MALDI tandem mass spectrometric imaging of cocaine from brain tissue with a deuterated internal standard publication-title: Anal Chem – volume: 5 start-page: e11411 year: 2010 ident: bib35 article-title: Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry publication-title: PLoS One – volume: 24 start-page: 92 year: 2013 end-page: 100 ident: bib11 article-title: Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) imaging source coupled to a FT-ICR mass spectrometer publication-title: J Am Soc Mass Spectrom – volume: 126 start-page: 177 year: 2005 end-page: 185 ident: bib22 article-title: MALDI mass spectrometric imaging of biological tissue sections publication-title: Mech Ageing Dev – volume: 83 start-page: 2112 year: 2011 end-page: 2118 ident: bib12 article-title: High-sensitivity MALDI-MRM-MS imaging of moxifloxacin distribution in tuberculosis-infected rabbit lungs and granulomatous lesions publication-title: Anal Chem – volume: 409 start-page: 4993 year: 2017 end-page: 5005 ident: bib63 article-title: Combination of MALDI-MSI and cassette dosing for evaluation of drug distribution in human skin explant publication-title: Anal Bioanal Chem – volume: 3 start-page: 3050 year: 2013 ident: bib16 article-title: The significance of microscopic mass spectrometry with high resolution in the visualisation of drug distribution publication-title: Sci Rep – volume: 6 start-page: 1647 year: 2014 end-page: 1656 ident: bib48 article-title: Recommendations from the European Bioanalysis Forum on method establishment for tissue homogenates publication-title: Bioanalysis – volume: 14 start-page: 90 year: 2017 end-page: 96 ident: bib18 article-title: Atmospheric pressure MALDI mass spectrometry imaging of tissues and cells at 1.4-mum lateral resolution publication-title: Nat Methods – volume: 84 start-page: 7158 year: 2012 end-page: 7165 ident: bib59 article-title: Evaluation of an accurate mass approach for the simultaneous detection of drug and metabolite distributions via whole-body mass spectrometric imaging publication-title: Anal Chem – volume: 286 start-page: 25459 year: 2011 end-page: 25466 ident: bib8 article-title: Imaging of intact tissue sections: moving beyond the microscope publication-title: J Biol Chem – volume: 19 start-page: 475 year: 2013 end-page: 482 ident: bib62 article-title: Impact of drug administration route on drug delivery and distribution into the lung: an imaging mass spectrometry approach publication-title: Eur J Mass Spectrom (Chichester) – volume: 65 start-page: 1074 year: 2013 end-page: 1085 ident: bib10 article-title: Qualitative and quantitative mass spectrometry imaging of drugs and metabolites publication-title: Adv Drug Deliv Rev – volume: 7 start-page: 493 year: 2001 end-page: 496 ident: bib5 article-title: Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues publication-title: Nat Med – volume: 7 start-page: 16763 year: 2017 ident: bib3 article-title: MALDI mass spectrometry imaging of erlotinib administered in combination with bevacizumab in xenograft mice bearing B901L, EGFR-mutated NSCLC cells publication-title: Sci Rep – volume: 88 start-page: 2392 issue: 4 year: 2016 ident: 10.1016/j.dmpk.2019.04.006_bib37 article-title: Absolute quantitative MALDI imaging mass spectrometry: a case of rifampicin in liver tissues publication-title: Anal Chem doi: 10.1021/acs.analchem.5b04409 – volume: 28 start-page: 1823 issue: 9 year: 2015 ident: 10.1016/j.dmpk.2019.04.006_bib57 article-title: Investigating nephrotoxicity of polymyxin derivatives by mapping renal distribution using mass spectrometry imaging publication-title: Chem Res Toxicol doi: 10.1021/acs.chemrestox.5b00262 – volume: 27 start-page: 117 issue: 1 year: 2016 ident: 10.1016/j.dmpk.2019.04.006_bib50 article-title: Mass spectrometry imaging of drug related crystal-like structures in formalin-fixed frozen and paraffin-embedded rabbit kidney tissue sections publication-title: J Am Soc Mass Spectrom doi: 10.1007/s13361-015-1254-3 – volume: 8 start-page: 575 issue: 6 year: 2016 ident: 10.1016/j.dmpk.2019.04.006_bib9 article-title: Novel insights in drug metabolism by MS imaging publication-title: Bioanalysis doi: 10.4155/bio-2015-0020 – volume: 75 start-page: 4941 issue: 16 year: 2012 ident: 10.1016/j.dmpk.2019.04.006_bib27 article-title: Novel mass spectrometry imaging software assisting labeled normalization and quantitation of drugs and neuropeptides directly in tissue sections publication-title: J Proteomics doi: 10.1016/j.jprot.2012.07.034 – volume: 6 start-page: 37027 year: 2016 ident: 10.1016/j.dmpk.2019.04.006_bib56 article-title: 3D mass spectrometry imaging reveals a very heterogeneous drug distribution in tumors publication-title: Sci Rep doi: 10.1038/srep37027 – volume: 175 start-page: 29 issue: 1 year: 2018 ident: 10.1016/j.dmpk.2019.04.006_bib23 article-title: Heterogeneous distribution of alectinib in neuroblastoma xenografts revealed by matrix-assisted laser desorption ionization mass spectrometry imaging: a pilot study publication-title: Br J Pharmacol doi: 10.1111/bph.14067 – volume: 75 start-page: 4952 issue: 16 year: 2012 ident: 10.1016/j.dmpk.2019.04.006_bib25 article-title: Quantitative mass spectrometry imaging of propranolol and olanzapine using tissue extinction calculation as normalization factor publication-title: J Proteomics doi: 10.1016/j.jprot.2012.07.035 – volume: 8 start-page: 343 issue: 1 year: 2018 ident: 10.1016/j.dmpk.2019.04.006_bib52 article-title: Distribution analysis of epertinib in brain metastasis of HER2-positive breast cancer by imaging mass spectrometry and prospect for antitumor activity publication-title: Sci Rep doi: 10.1038/s41598-017-18702-2 – volume: 90 start-page: 6275 issue: 10 year: 2018 ident: 10.1016/j.dmpk.2019.04.006_bib60 article-title: Visualization of mycobacterial biomarkers and tuberculosis drugs in infected tissue by MALDI-MS imaging publication-title: Anal Chem doi: 10.1021/acs.analchem.8b00985 – volume: 6 start-page: 33791 year: 2016 ident: 10.1016/j.dmpk.2019.04.006_bib54 article-title: Molecular imaging of brain localization of liposomes in mice using MALDI mass spectrometry publication-title: Sci Rep doi: 10.1038/srep33791 – volume: 21 start-page: 1223 issue: 10 year: 2015 ident: 10.1016/j.dmpk.2019.04.006_bib39 article-title: The association between sterilizing activity and drug distribution into tuberculosis lesions publication-title: Nat Med doi: 10.1038/nm.3937 – volume: 83 start-page: 9694 issue: 24 year: 2011 ident: 10.1016/j.dmpk.2019.04.006_bib30 article-title: Qualitative and quantitative MALDI imaging of the positron emission tomography ligands raclopride (a D2 dopamine antagonist) and SCH 23390 (a D1 dopamine antagonist) in rat brain tissue sections using a solvent-free dry matrix application method publication-title: Anal Chem doi: 10.1021/ac202630t – volume: 96 start-page: 224 issue: 2 year: 2014 ident: 10.1016/j.dmpk.2019.04.006_bib2 article-title: Intratumor heterogeneity and its impact on drug distribution and sensitivity publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2014.105 – volume: 26 start-page: 887 issue: 6 year: 2015 ident: 10.1016/j.dmpk.2019.04.006_bib28 article-title: Imaging MS in toxicology: an investigation of juvenile rat nephrotoxicity associated with dabrafenib administration publication-title: J Am Soc Mass Spectrom doi: 10.1007/s13361-015-1103-4 – volume: 42 start-page: 431 issue: 3 year: 2014 ident: 10.1016/j.dmpk.2019.04.006_bib51 article-title: Biodistribution and metabolism studies of lipid nanoparticle-formulated internally [3H]-labeled siRNA in mice publication-title: Drug Metab Dispos doi: 10.1124/dmd.113.055434 – volume: 28 start-page: 136 issue: 1 year: 2017 ident: 10.1016/j.dmpk.2019.04.006_bib44 article-title: Absolute quantification of rifampicin by MALDI imaging mass spectrometry using multiple TOF/TOF events in a single laser shot publication-title: J Am Soc Mass Spectrom doi: 10.1007/s13361-016-1501-2 – volume: 1865 start-page: 726 issue: 7 year: 2017 ident: 10.1016/j.dmpk.2019.04.006_bib31 article-title: Quantification of low molecular weight compounds by MALDI imaging mass spectrometry - a tutorial review publication-title: Biochim Biophys Acta Protein Proteonomics doi: 10.1016/j.bbapap.2016.12.011 – volume: 85 start-page: 10099 issue: 21 year: 2013 ident: 10.1016/j.dmpk.2019.04.006_bib21 article-title: A mimetic tissue model for the quantification of drug distributions by MALDI imaging mass spectrometry publication-title: Anal Chem doi: 10.1021/ac400892z – volume: 87 start-page: 1437 issue: 3 year: 2015 ident: 10.1016/j.dmpk.2019.04.006_bib14 article-title: Mass spectrometry imaging in drug development publication-title: Anal Chem doi: 10.1021/ac504734s – year: 2012 ident: 10.1016/j.dmpk.2019.04.006_bib46 – volume: 6 start-page: 23749 year: 2016 ident: 10.1016/j.dmpk.2019.04.006_bib38 article-title: Visualizing spatial distribution of alectinib in murine brain using quantitative mass spectrometry imaging publication-title: Sci Rep doi: 10.1038/srep23749 – volume: 3 start-page: 2427 issue: 21 year: 2011 ident: 10.1016/j.dmpk.2019.04.006_bib15 article-title: MALDI imaging mass spectrometry: bridging biology and chemistry in drug development publication-title: Bioanalysis doi: 10.4155/bio.11.232 – year: 2018 ident: 10.1016/j.dmpk.2019.04.006_bib47 – volume: 19 start-page: 475 issue: 6 year: 2013 ident: 10.1016/j.dmpk.2019.04.006_bib62 article-title: Impact of drug administration route on drug delivery and distribution into the lung: an imaging mass spectrometry approach publication-title: Eur J Mass Spectrom (Chichester) doi: 10.1255/ejms.1254 – volume: 409 start-page: 4993 issue: 21 year: 2017 ident: 10.1016/j.dmpk.2019.04.006_bib63 article-title: Combination of MALDI-MSI and cassette dosing for evaluation of drug distribution in human skin explant publication-title: Anal Bioanal Chem doi: 10.1007/s00216-017-0443-2 – volume: 90 start-page: 5637 issue: 9 year: 2018 ident: 10.1016/j.dmpk.2019.04.006_bib55 article-title: Exploring ion suppression in mass spectrometry imaging of a heterogeneous tissue publication-title: Anal Chem doi: 10.1021/acs.analchem.7b05005 – volume: 3 start-page: 3050 year: 2013 ident: 10.1016/j.dmpk.2019.04.006_bib16 article-title: The significance of microscopic mass spectrometry with high resolution in the visualisation of drug distribution publication-title: Sci Rep doi: 10.1038/srep03050 – volume: 407 start-page: 2329 issue: 8 year: 2015 ident: 10.1016/j.dmpk.2019.04.006_bib41 article-title: Mass spectrometry imaging of biological tissue: an approach for multicenter studies publication-title: Anal Bioanal Chem doi: 10.1007/s00216-014-8410-7 – volume: 65 start-page: 1074 issue: 8 year: 2013 ident: 10.1016/j.dmpk.2019.04.006_bib10 article-title: Qualitative and quantitative mass spectrometry imaging of drugs and metabolites publication-title: Adv Drug Deliv Rev doi: 10.1016/j.addr.2013.04.009 – volume: 102 start-page: 748 issue: 5 year: 2017 ident: 10.1016/j.dmpk.2019.04.006_bib53 article-title: Application of 3D mass spectrometry imaging to TKIs publication-title: Clin Pharmacol Ther doi: 10.1002/cpt.786 – volume: 407 start-page: 2177 issue: 8 year: 2015 ident: 10.1016/j.dmpk.2019.04.006_bib26 article-title: Quantification in MALDI-MS imaging: what can we learn from MALDI-selected reaction monitoring and what can we expect for imaging? publication-title: Anal Bioanal Chem doi: 10.1007/s00216-014-8315-5 – volume: 3 start-page: A0025 issue: 1 year: 2014 ident: 10.1016/j.dmpk.2019.04.006_bib29 article-title: Quantification of small molecule drugs in biological tissue sections by imaging mass spectrometry using surrogate tissue-based calibration standards publication-title: Mass Spectrom (Tokyo) doi: 10.5702/massspectrometry.A0025 – volume: 21 start-page: 187 issue: 2 year: 2016 ident: 10.1016/j.dmpk.2019.04.006_bib49 article-title: Exemplifying the screening power of mass spectrometry imaging over label-based Technologies for simultaneous monitoring of drug and metabolite distributions in tissue sections publication-title: J Biomol Screen doi: 10.1177/1087057115623740 – volume: 83 start-page: 2112 issue: 6 year: 2011 ident: 10.1016/j.dmpk.2019.04.006_bib12 article-title: High-sensitivity MALDI-MRM-MS imaging of moxifloxacin distribution in tuberculosis-infected rabbit lungs and granulomatous lesions publication-title: Anal Chem doi: 10.1021/ac1029049 – volume: 84 start-page: 7158 issue: 16 year: 2012 ident: 10.1016/j.dmpk.2019.04.006_bib59 article-title: Evaluation of an accurate mass approach for the simultaneous detection of drug and metabolite distributions via whole-body mass spectrometric imaging publication-title: Anal Chem doi: 10.1021/ac3015142 – volume: 31 start-page: 221 issue: 3 year: 2018 ident: 10.1016/j.dmpk.2019.04.006_bib4 article-title: Imaging mass spectrometry for toxicity assessment: a useful technique to confirm drug distribution in histologically confirmed lesions publication-title: J Toxicol Pathol doi: 10.1293/tox.2018-0006 – volume: 286 start-page: 25459 issue: 29 year: 2011 ident: 10.1016/j.dmpk.2019.04.006_bib8 article-title: Imaging of intact tissue sections: moving beyond the microscope publication-title: J Biol Chem doi: 10.1074/jbc.R111.225854 – volume: 14 start-page: 90 issue: 1 year: 2017 ident: 10.1016/j.dmpk.2019.04.006_bib18 article-title: Atmospheric pressure MALDI mass spectrometry imaging of tissues and cells at 1.4-mum lateral resolution publication-title: Nat Methods doi: 10.1038/nmeth.4071 – volume: 21 start-page: 564 issue: 4 year: 2010 ident: 10.1016/j.dmpk.2019.04.006_bib34 article-title: Quantitative MALDI-MS(n) analysis of cocaine in the autopsied brain of a human cocaine user employing a wide isolation window and internal standards publication-title: J Am Soc Mass Spectrom doi: 10.1016/j.jasms.2009.12.014 – volume: 84 start-page: 1310 issue: 3 year: 2012 ident: 10.1016/j.dmpk.2019.04.006_bib24 article-title: Robust data processing and normalization strategy for MALDI mass spectrometric imaging publication-title: Anal Chem doi: 10.1021/ac201767g – volume: 13 start-page: e1800029 issue: 1 year: 2019 ident: 10.1016/j.dmpk.2019.04.006_bib42 article-title: Site-to-Site reproducibility and spatial resolution in MALDI-MSI of peptides from formalin-fixed paraffin-embedded samples publication-title: Proteonomics Clin Appl doi: 10.1002/prca.201800029 – volume: 4 start-page: 2095 issue: 17 year: 2012 ident: 10.1016/j.dmpk.2019.04.006_bib19 article-title: Quantitation by MS imaging: needs and challenges in pharmaceuticals publication-title: Bioanalysis doi: 10.4155/bio.12.187 – issue: 77 year: 2013 ident: 10.1016/j.dmpk.2019.04.006_bib7 article-title: Imaging of biological tissues by desorption electrospray ionization mass spectrometry publication-title: J Vis Exp – volume: 410 start-page: 2815 issue: 11 year: 2018 ident: 10.1016/j.dmpk.2019.04.006_bib61 article-title: MALDI imaging facilitates new topical drug development process by determining quantitative skin distribution profiles publication-title: Anal Bioanal Chem doi: 10.1007/s00216-018-0964-3 – year: 2013 ident: 10.1016/j.dmpk.2019.04.006_bib45 – volume: 7 start-page: 16763 issue: 1 year: 2017 ident: 10.1016/j.dmpk.2019.04.006_bib3 article-title: MALDI mass spectrometry imaging of erlotinib administered in combination with bevacizumab in xenograft mice bearing B901L, EGFR-mutated NSCLC cells publication-title: Sci Rep doi: 10.1038/s41598-017-17211-6 – volume: 165 start-page: 128 year: 2017 ident: 10.1016/j.dmpk.2019.04.006_bib43 article-title: Optimization and evaluation of MALDI TOF mass spectrometric imaging for quantification of orally dosed octreotide in mouse tissues publication-title: Talanta doi: 10.1016/j.talanta.2016.12.049 – volume: 5 start-page: 31 issue: 1 year: 2010 ident: 10.1016/j.dmpk.2019.04.006_bib6 article-title: Imaging mass spectrometry for visualization of drug and endogenous metabolite distribution: toward in situ pharmacometabolomes publication-title: J Neuroimmune Pharmacol doi: 10.1007/s11481-009-9162-6 – volume: 83 start-page: 4266 issue: 11 year: 2011 ident: 10.1016/j.dmpk.2019.04.006_bib13 article-title: Single hair cocaine consumption monitoring by mass spectrometric imaging publication-title: Anal Chem doi: 10.1021/ac200610c – volume: 24 start-page: 92 issue: 1 year: 2013 ident: 10.1016/j.dmpk.2019.04.006_bib11 article-title: Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) imaging source coupled to a FT-ICR mass spectrometer publication-title: J Am Soc Mass Spectrom doi: 10.1007/s13361-012-0505-9 – volume: 145 start-page: 201 issue: 2 year: 2016 ident: 10.1016/j.dmpk.2019.04.006_bib32 article-title: Pharmacokinetic and pharmacometabolomic study of pirfenidone in normal mouse tissues using high mass resolution MALDI-FTICR-mass spectrometry imaging publication-title: Histochem Cell Biol doi: 10.1007/s00418-015-1382-7 – volume: 5 start-page: e11411 issue: 7 year: 2010 ident: 10.1016/j.dmpk.2019.04.006_bib35 article-title: Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry publication-title: PLoS One doi: 10.1371/journal.pone.0011411 – volume: 14 start-page: 1156 issue: 12 year: 2017 ident: 10.1016/j.dmpk.2019.04.006_bib17 article-title: Autofocusing MALDI mass spectrometry imaging of tissue sections and 3D chemical topography of nonflat surfaces publication-title: Nat Methods doi: 10.1038/nmeth.4433 – volume: 7 start-page: 493 issue: 4 year: 2001 ident: 10.1016/j.dmpk.2019.04.006_bib5 article-title: Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues publication-title: Nat Med doi: 10.1038/86573 – volume: 401 start-page: 167 issue: 1 year: 2011 ident: 10.1016/j.dmpk.2019.04.006_bib20 article-title: Normalization in MALDI-TOF imaging datasets of proteins: practical considerations publication-title: Anal Bioanal Chem doi: 10.1007/s00216-011-4929-z – volume: 163 start-page: 409 issue: 2 year: 2018 ident: 10.1016/j.dmpk.2019.04.006_bib58 article-title: Application of imaging techniques to cases of drug-induced crystal nephropathy in preclinical studies publication-title: Toxicol Sci doi: 10.1093/toxsci/kfx044 – volume: 126 start-page: 177 issue: 1 year: 2005 ident: 10.1016/j.dmpk.2019.04.006_bib22 article-title: MALDI mass spectrometric imaging of biological tissue sections publication-title: Mech Ageing Dev doi: 10.1016/j.mad.2004.09.032 – volume: 7 start-page: 12622 issue: 1 year: 2017 ident: 10.1016/j.dmpk.2019.04.006_bib40 article-title: Evaluation of the heterogeneous tissue distribution of erlotinib in lung cancer using matrix-assisted laser desorption ionization mass spectrometry imaging publication-title: Sci Rep doi: 10.1038/s41598-017-13025-8 – volume: 6 start-page: 39284 year: 2016 ident: 10.1016/j.dmpk.2019.04.006_bib36 article-title: Heterogeneity of paclitaxel distribution in different tumor models assessed by MALDI mass spectrometry imaging publication-title: Sci Rep doi: 10.1038/srep39284 – volume: 6 start-page: 1647 issue: 12 year: 2014 ident: 10.1016/j.dmpk.2019.04.006_bib48 article-title: Recommendations from the European Bioanalysis Forum on method establishment for tissue homogenates publication-title: Bioanalysis doi: 10.4155/bio.14.34 – volume: 75 start-page: 4999 issue: 16 year: 2012 ident: 10.1016/j.dmpk.2019.04.006_bib1 article-title: Mass spectrometry imaging for drug distribution studies publication-title: J Proteomics doi: 10.1016/j.jprot.2012.07.028 – volume: 85 start-page: 1081 issue: 2 year: 2013 ident: 10.1016/j.dmpk.2019.04.006_bib33 article-title: Quantitative MALDI tandem mass spectrometric imaging of cocaine from brain tissue with a deuterated internal standard publication-title: Anal Chem doi: 10.1021/ac302960j |
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| SubjectTerms | Animals Application Drug Drug Development - methods Humans LC-MS/MS MALDI Mass spectrometry imaging Pharmaceutical Preparations - analysis Pharmacokinetics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Standardization Validation |
| Title | Applications of MALDI mass spectrometry imaging for pharmacokinetic studies during drug development |
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