Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness

• Published in: Human molecular genetics Vol. 28; no. 22; pp. 3853 - 3865
• Main Authors: Abdellaoui, Abdel, Sanchez-Roige, Sandra, Sealock, Julia, Treur, Jorien L, Dennis, Jessica, Fontanillas, Pierre, Elson, Sarah, Nivard, Michel G, Ip, Hill Fung, van der Zee, Matthijs, Baselmans, Bart M L, Hottenga, Jouke Jan, Willemsen, Gonneke, Mosing, Miriam, Lu, Yi, Pedersen, Nancy L, Denys, Damiaan, Amin, Najaf, M van Duijn, Cornelia, Szilagyi, Ingrid, Tiemeier, Henning, Neumann, Alexander, Verweij, Karin J H, Cacioppo, Stephanie, Cacioppo, John T, Davis, Lea K, Palmer, Abraham A, Boomsma, Dorret I
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 15.11.2019
• Subjects: Association Studies; Female; Genetic Predisposition to Disease - genetics; Genome-Wide Association Study - methods; Genotype; Health; Humans; Loneliness - psychology; Male; Mendelian Randomization Analysis - methods; Mental Disorders - genetics; Mental Health; Multifactorial Inheritance - genetics; Phenomics - methods; Phenotype; Polymorphism, Single Nucleotide - genetics

Abstract Humans are social animals that experience intense suffering when they perceive a lack of social connection. Modern societies are experiencing an epidemic of loneliness. Although the experience of loneliness is universally human, some people report experiencing greater loneliness than others...