RAD21 amplification epigenetically suppresses interferon signaling to promote immune evasion in ovarian cancer

• Published in: The Journal of clinical investigation Vol. 132; no. 22; pp. 1 - 16
• Main Authors: Deng, Peng, Wang, Zining, Chen, Jinghong, Liu, Shini, Yao, Xiaosai, Liu, Shaoyan, Liu, Lizhen, Yu, Zhaoliang, Huang, Yulin, Xiong, Zhongtang, Xiao, Rong, Gao, Jiuping, Liang, Weiting, Chen, Jieping, Liu, Hui, Hong, Jing Han, Chan, Jason Yongsheng, Guan, Peiyong, Chen, Jianfeng, Wang, Yali, Yin, Jiaxin, Li, Jundong, Zheng, Min, Zhang, Chao, Zhou, Penghui, Kang, Tiebang, Teh, Bin Tean, Yu, Qiang, Zuo, Zhixiang, Jiang, Qingping, Liu, Jihong, Xiong, Ying, Xia, Xiaojun, Tan, Jing
• Format: Journal Article
• Language: English
• Published: Ann Arbor American Society for Clinical Investigation 15.11.2022
• Subjects: Ablation; Animal models; Apoptosis; Biomedical research; Bladder cancer; CD8 antigen; Cohesin; Copy number; Fallopian tubes; Gene amplification; Gene expression; Genomes; Histone deacetylase; Immune evasion; Immunology; Immunomodulation; Immunotherapy; Interferon; Lymphocytes T; Medical prognosis; Melanoma; Mutation; NuRD protein; Oncology; Ovarian cancer; PD-1 protein; Proteins; Roles; Stem cells; Survival analysis; Tumorigenesis; Tumors; Yes-associated protein

Prevalent copy number alteration is the most prominent genetic characteristic associated with ovarian cancer (OV) development, but its role in immune evasion has not been fully elucidated. In this study, we identified RAD21, a key component of the cohesin complex, as a frequently amplified oncogene...