Biomimetic nanoreactor for targeted cancer starvation therapy and cascade amplificated chemotherapy

• Published in: Biomaterials Vol. 274; p. 120869
• Main Authors: Shao, Fengying, Wu, Yafeng, Tian, Zhaoyan, Liu, Songqin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.07.2021
• Subjects: Biomimetic nanoreactor; Cascade amplification; Glucose oxidase; Hypoxia activated chemotherapy; Starvation therapy; Biomimetic nanoreactor; Glucose oxidase; Cascade amplification; Starvation therapy; Hypoxia activated chemotherapy

Consuming glucose by glucose oxidase (GOx) has attracted great interest in cancer starvation therapy, but the therapeutic effect is severely limited by the tumor hypoxia environment. Herein, to overcome such limitation, cancer cell membranes disguised biomimetic nanoreactors were elaborately establi...