GPCR Modulation in Breast Cancer

• Published in: International journal of molecular sciences Vol. 19; no. 12; p. 3840
• Main Authors: Lappano, Rosamaria, Jacquot, Yves, Maggiolini, Marcello
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.12.2018; MDPI
• Subjects: Amino acids; Biochemistry, Molecular Biology; Breast cancer; Cancer; Cancer therapies; Cell growth; Epidermal growth factor; Estrogens; Gene amplification; Kinases; Life Sciences; Ligands; Metastasis; Physiology; Proteins; Review; Tumorigenesis; Tumors; signal transduction; breast cancer; GPCRs

Breast cancer is the most prevalent cancer found in women living in developed countries. Endocrine therapy is the mainstay of treatment for hormone-responsive breast tumors (about 70% of all breast cancers) and implies the use of selective estrogen receptor modulators and aromatase inhibitors. In co...