Patterns of evolutionary selection pressure in the immune signaling protein TRAF3IP2 in mammals

• Published in: Gene Vol. 531; no. 2; pp. 403 - 410
• Main Authors: Wu, Baojun, Gong, Jing, Yuan, Shoudao, Zhang, Ying, Wei, Tiandi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2013
• Subjects: Adaptive evolution; amino acids; Animals; autoimmunity; Cattle; chemistry; coevolution; Competitive coevolution; Evolution, Molecular; genetics; Guinea Pigs; Host-Pathogen Interactions; Host-Pathogen Interactions - genetics; Host-Pathogen Interactions - immunology; hosts; Humans; Immune defense; immune response; Immunity; Immunity - genetics; immunology; Mammalian TRAF3IP2; mammals; Mammals - genetics; Mammals - immunology; Mice; Models, Molecular; pathogens; Rabbits; Rats; Selection, Genetic; Signal Transduction; Signal Transduction - genetics; Signal Transduction - immunology; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - chemistry; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics; viruses; CC; IKKi; TRAF3IP2; HLH; FUBAR; Competitive coevolution; FEL; IL17R; SEFIR; Adaptive evolution; CIKS; dN/dS; NF-κB; Mammalian TRAF3IP2; BAFFR; MEME; IDR; TRAF6; NG; Immune defense; NJ; TIR; SLAC; fixed effects likelihood; nonsynonymous/synonymous substitution rate ratio; TNF receptor associated factor 6; intrinsically disordered region; SEF/interleukin 17 receptor; single likelihood ancestor counting; IκB kinase I; TNF receptor associated factor 3 interacting protein 2; fast unconstrained Bayesian approximation; interleukin 17 receptor; Nei–Gojobori; neighbor-joining; Toll/interleukin 1 receptor; B-cell-activating factor receptor; helix–loop–helix; nuclear factor-kappa B; SAPK/JNK; mixed effects model of evolution; coiled-coil

TRAF3 interacting protein 2 (TRAF3IP2) is important for immune responses to pathogens, inflammatory signals and autoimmunity in mammals. In the present study, we collected 19 mammalian TRAF3IP2 sequences and investigated the various types of selection pressure acting on them. Maximum likelihood esti...