Glial-associated changes in the cerebral cortex after collagenase-induced intracerebral hemorrhage in the rat striatum

• Published in: Brain research bulletin Vol. 134; pp. 55 - 62
• Main Authors: Neves, J.D., Aristimunha, D., Vizuete, A.F., Nicola, F., Vanzella, C., Petenuzzo, L., Mestriner, R.G., Sanches, E.F., Gonçalves, C.A., Netto, C.A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2017
• Subjects: Animals; Cellular events; Cerebral Cortex - pathology; Cerebral Cortex - physiopathology; Cerebral Hemorrhage - pathology; Cerebral Hemorrhage - physiopathology; Collagenases; Corpus Striatum - pathology; Corpus Striatum - physiopathology; Cortex; Disease Models, Animal; Disease Progression; Forelimb - physiopathology; Glial changes; Glial Fibrillary Acidic Protein - metabolism; Hemorrhagic stroke; Male; Motor Activity; Movement Disorders - pathology; Movement Disorders - physiopathology; Muscle Strength; Neuroglia - pathology; Neuroglia - physiology; Rats, Wistar; S100 Calcium Binding Protein beta Subunit - metabolism; Striatum; Striatum; Glial changes; Cellular events; Hemorrhagic stroke; Cortex

•Sensorimotor cortex is susceptible to the striatal hemorrhagic injury.•Striatal ICH causes glial changes in the cerebral cortex with similar patterns and evolution as those in the striatum.•Glial effects are associated to lesion progression and functional sensorimotor outcome. Striatum and the cere...