Enolase 1 regulates stem cell-like properties in gastric cancer cells by stimulating glycolysis

• Published in: Cell death & disease Vol. 11; no. 10; p. 870
• Main Authors: Yang, Ting, Shu, Xiong, Zhang, Hui-Wen, Sun, Li-Xin, Yu, Long, Liu, Jun, Sun, Li-Chao, Yang, Zhi-Hua, Ran, Yu-Liang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.10.2020
• Subjects: 13; 13/100; 13/109; 13/51; 13/89; 631/67/395; 631/67/71; 631/80/304; 64; 64/60; 82; 82/80; Antibodies; Biochemistry; Biomarkers, Tumor - metabolism; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell Line, Tumor; Cell Proliferation - physiology; DNA-Binding Proteins - metabolism; Gene Expression Regulation, Neoplastic - genetics; Glycolysis - genetics; Glycolysis - physiology; Humans; Immunology; Life Sciences; Neoplastic Stem Cells - metabolism; Phosphopyruvate Hydratase - genetics; Phosphopyruvate Hydratase - metabolism; Stomach - pathology; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Tumor Suppressor Proteins - metabolism

Recent studies have demonstrated that gastric cancer stem cells (CSCs) are a rare sub-group of gastric cancer (GC) cells and have an important role in promoting the tumor growth and progression of GC. In the present study, we demonstrated that the glycolytic enzyme Enolase 1 (ENO1) was involved in t...