Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability

• Published in: Trends in genetics Vol. 37; no. 6; pp. 566 - 581
• Main Authors: Mattiroli, Francesca, Penengo, Lorenza
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2021
• Subjects: chromatin modifications; DDR; DNA damage response; H2AK15ub; pUbT12; RNF8/RNF168/USP51; ubiquitin phosphorylation; pUbT12; DDR; DNA damage response; ubiquitin phosphorylation; chromatin modifications; H2AK15ub; RNF8/RNF168/USP51

Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) code and of chromatin modifications and dynamics challenges our ability to fully understand how histone ubiquitination...