Drug delivery device for the inner ear: ultra-sharp fully metallic microneedles

• Published in: Drug delivery and translational research Vol. 11; no. 1; pp. 214 - 226
• Main Authors: Aksit, Aykut, Rastogi, Shruti, Nadal, Maria L., Parker, Amber M., Lalwani, Anil K., West, Alan C., Kysar, Jeffrey W.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2021
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Drug Delivery Systems; Ear, Inner; Guinea Pigs; Needles; Original Article; Pharmaceutical Preparations; Pharmaceutical Sciences/Technology; Round Window, Ear; Round window membrane; Electrochemical deposition; Inner ear drug delivery; Microneedles; Hybrid additive manufacturing; Nanoscribe; 2PTE

Drug delivery into the inner ear is a significant challenge due to its inaccessibility as a fluid-filled cavity within the temporal bone of the skull. The round window membrane (RWM) is the only delivery portal from the middle ear to the inner ear that does not require perforation of bone. Recent ad...