Formalin-induced nociceptive responses in diabetic mice

• Published in: Neuroscience letters Vol. 149; no. 2; pp. 161 - 164
• Main Authors: Kamei, Junzo, Hitosugi, Hideki, Kasuya, Yutaka
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 12.01.1993; Elsevier
• Subjects: Analgesics - administration & dosage; Analgesics - pharmacology; Animals; Behavior, Animal - drug effects; Biological and medical sciences; Diabetes; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - metabolism; Dose-Response Relationship, Drug; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Formaldehyde - pharmacology; Formalin; Injections, Spinal; Male; Medical sciences; Mice; Mice, Inbred ICR; Naltrexone - administration & dosage; Naltrexone - analogs & derivatives; Naltrexone - pharmacology; Naltrindole; Narcotic Antagonists - administration & dosage; Narcotic Antagonists - pharmacology; Nociception; Nociceptors - drug effects; Receptors, Opioid, delta - drug effects; Spantide; Substance P; Substance P - administration & dosage; Substance P - analogs & derivatives; Substance P - pharmacology; Nociception; Formalin; Naltrindole; Diabetes; Substance P; Spantide; Endocrinopathy; Opiate receptor δ; Diabetes mellitus; Rodentia; Vertebrata; Experimental disease; Mammalia; Pain; Mouse; Animal; Antagonist; Streptozotocin

In non-diabetic mice, s.c. injection of formalin to the hindpaw had a biphasic effect: an immediate nociceptive response (first-phase) followed by a tonic response (second-phase). However, only the immediate nociceptive response was observed in diabetic mice. The duration of the first-phase response...